Epidemiology of Breast Arterial Calcification

乳腺动脉钙化的流行病学

• 批准号: 6950003
• 负责人: DANA H WHALEY
• 金额: $ 11.61万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-17 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6950003
• 关键词: atherosclerosis; bioimaging /biomedical imaging; calcification; cardiovascular disorder diagnosis; cardiovascular disorder risk; cardiovascular imaging /visualization; clinical research; comorbidity; coronary disorder; female; human subject; mammography; myocardial infarction; patient oriented research; sudden cardiac death; tomography; women' s health

DESCRIPTION (provided by applicant): The study hypothesis is that breast arterial calcification (BAC) seen on mammograms can identify women with an increased risk of coronary artery disease (CAD). Annual mammograms are now routinely obtained on nearly 70% of women over forty years of age. The nearly 40 million examinations performed every year could be used to evaluate for BAC without any additional cost or change in current mammographic techniques. Identification of women with BAC has potential to substantially decrease the rate of heart attack and sudden death due to CAD in asymptomatic women. Before BAC can be used in a clinical setting, the age-specific prevalence of BAC needs to be fully defined using state of the art mammographic techniques. BAC then needs to be compared with well understood CAD risk factors and measures of coronary atherosclerosis. While this could be accomplished in a prospective study, we can attain the same goals using data already acquired in the Epidemiology of Coronary Calcification (ECAC) Study. Using this preexisting database fulfills one of the requirements for this NHLBI R21 Grant. Coronary artery calcification (CAC) is detected non-invasively on electron beam computed tomographic (EBCT) exams. CAC quantity correlates well with atherosclerotic plaque area. This population-based study has been instrumental in establishing the distribution of presence and quantity of CAC as well as the predictors of CAC. The database includes clinical and laboratory assessments of CAD risk factors, results of EBCTs, and findings on physical examinations. It will ultimately include information on adverse clinical events. There are 612 female participants who had one or more mammograms during the 12-year history of that study. Many women had 10 or more mammograms. The proposal is to evaluate all of these mammograms for BAC and compare the findings with information already in the database. The combination of newly acquired data from mammograms with the existing data allows this to be a very comprehensive study and still be completed in the two-year time period and with the funding constraints of this R21 grant. The findings can then be used to help design a future study to prospectively evaluate the impact of instituting preventive and early therapeutic measures for CAD in asymptomatic women with the appropriate features of BAC on mammography.

描述（由申请人提供）：研究假设是，乳房 X 光检查中看到的乳腺动脉钙化 (BAC) 可以识别患有冠状动脉疾病 (CAD) 风险增加的女性。现在，近 70% 的 40 岁以上女性每年都会定期进行乳房 X 光检查。每年进行的近 4000 万次检查可用于评估 BAC，而无需任何额外成本或改变当前的乳房 X 线摄影技术。识别患有 BAC 的女性有可能大幅降低无症状女性因 CAD 导致的心脏病发作率和猝死率。在将 BAC 用于临床之前，需要使用最先进的乳房 X 线摄影技术来完全确定 BAC 的特定年龄患病率。然后需要将 BAC 与众所周知的 CAD 危险因素和冠状动脉粥样硬化测量进行比较。虽然这可以通过前瞻性研究来实现，但我们可以使用冠状动脉钙化流行病学 (ECAC) 研究中已获得的数据来实现相同的目标。使用这个预先存在的数据库可以满足 NHLBI R21 拨款的要求之一。冠状动脉钙化 (CAC) 可通过电子束计算机断层扫描 (EBCT) 检查进行无创检测。 CAC 数量与动脉粥样硬化斑块面积密切相关。这项基于人群的研究有助于确定 CAC 的存在和数量的分布以及 CAC 的预测因素。该数据库包括 CAD 危险因素的临床和实验室评估、EBCT 结果以及体检结果。它将最终包括有关不良临床事件的信息。在该研究的 12 年历史中，有 612 名女性参与者接受过一次或多次乳房 X 光检查。许多女性接受了 10 次或更多乳房 X 光检查。该提案旨在评估所有这些乳房 X 光检查的 BAC 并将结果与​​数据库中已有的信息进行比较。将新获得的乳房 X 光检查数据与现有数据相结合，使这项研究成为一项非常全面的研究，并且仍可在两年时间内完成，并且受到 R21 拨款的资金限制。研究结果可用于帮助设计一项未来的研究，前瞻性评估对具有适当 BAC 特征的无症状女性 CAD 采取预防和早期治疗措施对乳房 X 光检查的影响。