Neural and metabolic activity in vision and attention

视觉和注意力的神经和代谢活动

• 批准号: 6650701
• 负责人: JACK L GALLANT
• 金额: $ 18.52万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6650701
• 关键词: Macaca; action potentials; attention; behavior test; behavioral /social science research tag; biosensor device; brain electrical activity; brain imaging /visualization /scanning; charge coupled device camera; digital imaging; electrodes; electroencephalography; electrophysiology; fiber optics; fluorescent dye /probe; hemodynamics; metabolism; neurophysiology; oxygen transport; technology /technique development; ultrasound blood flow measurement; vision

DESCRIPTION (provided by applicant): Current methods for functional imaging of the human brain do not record neural activity directly, but instead measure metabolic activity consequent to neural activity. In contrast, much of our understanding of the function of the human brain comes from electrophysiological studies in animals that allow direct access to the neural signals underlying cognitive function. It is difficult to bridge the gap between neural and metabolic activity; their interrelationship is quite complex and depends on several biological and experimental factors. We propose to investigate the relationship between neural, metabolic and hemodynamic processes by use of a novel multispectral probe that allows simultaneous measurement of neural, metabolic and hemodynamic signals: spiking activity from multiple isolated single cells, local field potentials, EEG, local perfused 02 and local blood flow. This system will be used to quantify and characterize the relationship between neurophysiological and metabolic measures in an awake behaving animal model of human cognitive function. Subsequent experiments will use the multispectral probe to investigate neural, metabolic and hemodynamic signals in basic studies of visual function. A multispectral probe that is flexible and cheap enough to be integrated with daily neurophysiological recordings will enable a wide range of neurophysiologists to routinely make simultaneous measurements of neural, metabolic and hemodynamic activity. Information gained by the routine use of such a probe by the wider neurophysiological community could have dramatic effects on our interpretation and understanding of data acquired in neuroimaging experiments.

描述（由申请人提供）： 目前的人脑功能成像方法并不直接记录神经活动，而是测量神经活动引起的代谢活动。相比之下，我们对人脑功能的大部分理解来自于动物的电生理学研究，这些研究允许直接获取认知功能背后的神经信号。神经活动和代谢活动之间的差距很难弥合；它们的相互关系相当复杂，取决于几个生物学和实验因素。我们建议通过使用一种新型多光谱探针来研究神经、代谢和血液动力学过程之间的关系，该探针允许同时测量神经、代谢和血液动力学信号：来自多个分离的单细胞的尖峰活动、局部场电位、脑电图、局部灌注 02 和局部血流量。该系统将用于量化和表征人类认知功能的清醒行为动物模型中神经生理学和代谢测量之间的关系。后续实验将使用多光谱探针来研究视觉功能基础研究中的神经、代谢和血流动力学信号。灵活且便宜的多光谱探头足以与日常神经生理学记录集成，将使广泛的神经生理学家能够定期同时测量神经、代谢和血流动力学活动。更广泛的神经生理学界通过常规使用这种探针获得的信息可能会对我们对神经影像实验中获得的数据的解释和理解产生巨大的影响。