IN VIVO OPTICAL DIAGNOSIS OF ORAL MALIGNANCY IN HUMAN SUBJECTS

人类受试者口腔恶性肿瘤的体内光学诊断

• 批准号: 7180312
• 负责人: TATIANA B KRASIEVA
• 金额: $ 1.15万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7180312
• 关键词: bioimaging /biomedical imaging; biomedical resource; biotechnology; clinical research; imaging /visualization /scanning; lasers

DESCRIPTION (provided by applicant): The Laser Microbeam and Medical Program (LAMMP) is a NIH Biomedical Technology Resource Center dedicated to the use of lasers and optics in biology and medicine. LAMMP is located within the Beckman Laser Institute (BLI), an interdisciplinary biomedical research, teaching, and clinical facility at the University of California, Irvine. The BLI functions administratively as a division within the Department of Surgery in the Medical School at UC Irvine. Overall resource objectives are to promote a well-balanced Center with activities in technological research and development, collaborative/service research, and training/dissemination. In this fifth renewal application of LAMMP, we emphasize our unique capabilities to facilitate "translational" research by rapidly moving basic science and technology discoveries from "benchtop to bedside". This is accomplished by combining state of the art optical technologies with our in-house facilities in cellular and tissue engineering, animal models, and human subjects. LAMMP provides both Microbeam and Microscopy Technologies (MMT) for optical manipulation and functional imaging of living cells and tissues, and Medical Translational Technologies (MTT) for monitoring, treating, and imaging pre-clinical animal models and human subjects. A total of six new technology research and development projects are proposed that will result in the construction of 5 new, dedicated instruments. MMT and MTr technologies am linked together by a common set of optical technologies, computational models, data visualization methods, and biomedical applications. Combined, they are capable of characterizing and imaging structure and biochemical composition in tissues with scalable resolution and depth sensitivity ranging from microns to centimeters. This allows selective interrogation of the essential components of tissue: molecules, cells, extracellular matrix, and vasculature. Throughout the grant cycle, we will apply these emerging methods to biological models and clinical problems in order to characterize and quantify the precise structural and functional origins of intrinsic optical signals. Our long-term goal is to advance these technologies so they become widely-available, enabling methods for solving fundamentally important problems in biology and medicine.

描述（由申请人提供）： 激光微型和医疗计划（LAMMP）是NIH生物医学技术中心，致力于在生物学和医学中使用激光和光学。 LAMMP位于欧文分校的跨学科生物医学研究，教学和临床设施贝克曼激光研究所（BLI）内。 BLI在欧文分校的医学院手术系中行政用作作为部门。总体资源目标是通过技术研发，协作/服务研究以及培训/传播的活动来促进一个平衡的中心。在LAMMP的第五次续订应用中，我们强调了我们独特的能力，可以通过快速将基础科学和技术发现从“台式到床边”移动到“转化”研究。这是通过将最先进的光学技术与我们在细胞和组织工程，动物模型和人类受试者中的内部设施相结合来实现的。 LAMMP提供了微型和显微镜技术（MMT），用于对活细胞和组织的光学操纵和功能成像，以及医学转化技术（MTT），用于监测，治疗和成像临床前动物模型和人类受试者。总共提出了六个新的技术研发项目，这些项目将导致建造5种新的专用仪器。 MMT和MTR技术通过一组通用的光学技术，计算模型，数据可视化方法和生物医学应用链接在一起。结合在一起，它们能够表征和成像结构以及可扩展分辨率和深度灵敏度的组织中的生化组成，从微米到厘米。这允许对组织的基本组成部分进行选择性询问：分子，细胞，细胞外基质和脉管系统。在整个赠款周期中，我们将将这些新兴方法应用于生物模型和临床问题，以表征和量化内在光学信号的确切结构和功能起源。我们的长期目标是推进这些技术，以便它们变得广泛可用，从而有助于解决生物学和医学中重要的重要问题。