USF Scholars in Patient-Oriented Research (SPOR)

南佛罗里达大学以患者为导向的研究学者 (SPOR)

• 批准号: 6846421
• 负责人: Kenneth S. Zuckerman
• 金额: $ 30万
• 依托单位: UNIVERSITY OF SOUTH FLORIDA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6846421
• 关键词: bioinformatics; career; clinical research; curriculum; educational resource design /development; epidemiology; ethics; experimental designs; health science manpower; health science profession; health science research; mentoring /mentor; patient oriented research; postgraduate education; statistics /biometry; training; university

DESCRIPTION (provided by applicant): This is a proposal is for a Scholars in Patient-Oriented Research (SPOR) Program at the University of South Florida (USF). USF has made major strides over the past decade toward the goal of becoming a major research university increasing external research funding from less than $25M to nearly $250M annually. Over half of this funding is in the Health Sciences Center (HSC). About half of this funding currently is from industry-sponsored clinical therapeutic trials, and with the other half of the funding is for investigator-initiated research. Thus, it is a priority of the USF HSC to concentrate on developing a strong cadre of faculty members with expertise in patient-oriented research that is capable of receiving peer-reviewed external funding, in addition, we have a clear need to upgrade the subspecialty fellowship training programs to train increasing numbers of subspecialty fellows to become academic clinical and translational researchers. The K30 grant is an ideal mechanism for jumpstarting these efforts. Fortunately, within our institution the Moffitt Cancer Center, an NCI-designated Comprehensive Cancer Center, has done an outstanding job of building a clinical research program, a clinical and translational research mentoring program for junior faculty, and a NCI K12- funded Clinical and Translational Research Training program. The proposed program will utilize the expertise developed at Moffitt, as well as many of the smaller foci of clinical research expertise at USF, to train junior faculty and fellows. The SPOR Program will lead to a Masters degree. It will consist of a core of classroom and web-based didactic teaching and a mentored clinical research project. Many of the courses already exist, and others will be derived from current courses, whereas some courses will be designed specifically for SPOR Program trainees. Required courses will include research and professional ethics; grantsmanship; scientific writing; diversity in clinical research; principles of cell biology, physiology, pharmacology, and molecular biology; biostatistics and informatics; fundamentals of successful patient-oriented research. There will be three tracks available: therapeutic clinical researchers (clinical trial design; Phase I/II clinical trial design, conduct, analysis and funding), population-based research (epidemiology and trial design), mechanisms of human disease (molecular basis of metabolism, clinical pharmacology, bioinformatics). A thesis or peer-reviewed publication(s) based on mentored research will be required. The executive committee will oversee the Program and will have subcommittees for (1) trainee selection, (2) mentor selection (3) curriculum (4) evaluation processes; and (5) overall SPOR Program progress. Process assessment will be based on evaluations of courses, mentored research, and the Program overall. The major long-term outcomes evaluated will include the number of trainees in academic positions, trainees doing productive clinical research (manuscripts and abstracts), and trainees with national peer-review funded clinical and translational research proqrams.

描述（由申请人提供）： 这是针对南佛罗里达大学 (USF) 的以患者为导向的研究学者 (SPOR) 计划的提案。 南佛罗里达大学在过去十年中朝着成为主要研究型大学的目标取得了重大进展，外部研究经费从每年不足 2500 万美元增加到近 2.5 亿美元。 超过一半的资金用于健康科学中心 (HSC)。 目前，大约一半的资金来自行业赞助的临床治疗试验，另一半资金用于研究者发起的研究。 因此，USF HSC 的首要任务是集中精力培养一支强大的教职人员队伍，他们在以患者为导向的研究方面具有专业知识，能够接受同行评审的外部资金，此外，我们明确需要升级子专业奖学金培训计划，培训越来越多的专科研究员成为学术临床和转化研究人员。 K30 拨款是启动这些努力的理想机制。 幸运的是，在我们机构内，NCI 指定的综合癌症中心莫菲特癌症中心在建立临床研究项目、针对初级教师的临床和转化研究指导项目以及 NCI K12 资助的临床和转化研究方面做出了出色的工作。研究培训计划。 拟议的项目将利用莫菲特开发的专业知识以及南佛罗里达大学许多较小的临床研究专业知识中心来培训初级教员和研究员。 SPOR 项目将授予硕士学位。 它将包括课堂和网络教学的核心以及指导的临床研究项目。 许多课程已经存在，其他课程将源自现有课程，而某些课程将专门为 SPOR 计划学员设计。 必修课程包括研究和职业道德；赠款；科学写作；临床研究的多样性；细胞生物学、生理学、药理学和分子生物学原理；生物统计学和信息学；成功的以患者为导向的研究的基础。 将有三个方向：治疗性临床研究人员（临床试验设计；I/II 期临床试验设计、实施、分析和资助）、基于人群的研究（流行病学和试验设计）、人类疾病机制（代谢的分子基础） 、临床药理学、生物信息学）。 需要基于指导研究的论文或同行评审的出版物。 执行委员会将监督该计划，并设有小组委员会负责 (1) 学员选择，(2) 导师选择，(3) 课程，(4) 评估流程； (5) SPOR 计划的总体进展。 过程评估将基于对课程、指导研究和整个计划的评估。 评估的主要长期成果将包括担任学术职务的受训人员数量、进行富有成效的临床研究（手稿和摘要）的受训人员数量以及接受国家同行评审资助的临床和转化研究计划的受训人员数量。