Insulin Sensitivity in Children with low Birth Weight

低出生体重儿童的胰岛素敏感性

• 批准号: 6952674
• 负责人: MELINDA S SOTHERN
• 金额: $ 25.63万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-24 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6952674
• 关键词: African American; bioenergetics; blood pressure; body composition; calorimetry; cardiovascular disorder risk; caucasian American; clinical research; glucose tolerance test; high density lipoproteins; human subject; insulin sensitivity /resistance; interview; low birth weight infant human; low density lipoprotein; middle childhood (6-11); nuclear magnetic resonance spectroscopy; obesity; photon absorptiometry; questionnaires; racial /ethnic difference; striated muscles; triglycerides

DESCRIPTION (provided by applicant): Low birth weight is associated with impaired insulin sensitivity later in life. The relationship may be due to intrauterine growth retardation, which causes metabolic disorders and ultimately promotes diabetes mellitus, especially in genetically vulnerable individuals. However, the relationship, if present, is not well established in African Americans. Only one study has attempted to examine the relationships between low birth weight, ethnicity and insulin sensitivity in children under 14 years of age but, none during the critical period of obesity development (adiposity rebound at 7-9y). More importantly, mechanisms connecting low birth weight to impaired insulin sensitivity have yet to be identified. These mechanisms may originate in the intrauterine environment, be exacerbated in susceptible populations, and be further promoted by an early environment conducive to obesity. We propose that young African American children with low birth weight may be predisposed genetically and behaviorally to the early manifestation of subtle, nonsymptomatic metabolic abnormalities that work synergistically to create a childhood obesity phenotype. The metabolic abnormalities increasing the propensity to obesity and type 2 diabetes may originate earlier than previously proposed. In adults insulin sensitivity is correlated negatively with lipid depots in the skeletal muscle (intramyocellular lipids = IMCL) and in the liver long before the development of diabetes. Non-invasive techniques for examining the relationship of skeletal muscle and liver lipids to insulin sensitivity have not been applied to prepubertal African American or Caucasian youth with low birth weight. In this study we propose to examine the relationship of birth weight (low vs. normal) and ethnicity (African American vs. Caucasian) to insulin sensitivity in 7-9 year old African American and Caucasian children (with and without adjusting for total body fat). We will explore potential mechanisms of the impaired insulin sensitivity observed in 7-9 year old prepubertal children by examining the relationships between insulin sensitivity and ectopic fat deposition (triglyceride content in skeletal muscle and liver), abdominal fat, resting energy metabolism (REE and respiratory quotient [RQ]) and cardiovascular disease risk factors (lipid profiles and blood pressure). Insulin Sensitivity will be measured by Frequently Sampled Intravenous Glucose Tolerance Test (FSIGTT), triglyceride contents in skeletal muscle and liver by Nuclear Magnetic Resonance Spectroscopy (1H-MRS) and energy metabolism by ventilated hood indirect calorimetry.

描述（由申请人提供）：低出生体重与以后生活中的胰岛素敏感性受损有关。这种关系可能是由于宫内生长迟缓引起的，导致代谢性疾病并最终促进糖尿病，尤其是在遗传脆弱的个体中。但是，如果存在这种关系，在非洲裔美国人中并没有很好地建立。 只有一项研究试图检查14岁以下儿童的低出生体重，种族和胰岛素敏感性之间的关系，但在肥胖发展的关键时期（肥胖为7-9岁）中没有一个。 更重要的是，将低出生体重连接到胰岛素敏感性受损的机制尚未确定。 这些机制可能起源于宫内环境，在易感人群中加剧，并通过有利于肥胖症的早期环境进一步促进。我们建议，低出生体重的年轻儿童在遗传和行为上可能会倾向于早期表现出微妙的，无症状的代谢异常，这些异常是协同起作用的，从而创造了童年肥胖表型。代谢异常增加了肥胖倾向和2型糖尿病的倾向可能比以前提出的早期起源。 在成年人中，胰岛素敏感性与骨骼肌（细胞内脂质= IMCL）中的脂质仓库和肝脏中的脂质库有负相关。用于检查骨骼肌和肝脂质与胰岛素敏感性的关系的非侵入性技术尚未应用于低出生体重的青春期前非洲裔美国人或白种人青年。在这项研究中，我们建议研究出生体重（低与正常）和种族（非裔美国人与高加索人）与7-9岁的非洲裔美国人和高加索儿童（有和没有调整全身脂肪的调整）之间的胰岛素敏感性。 We will explore potential mechanisms of the impaired insulin sensitivity observed in 7-9 year old prepubertal children by examining the relationships between insulin sensitivity and ectopic fat deposition (triglyceride content in skeletal muscle and liver), abdominal fat, resting energy metabolism (REE and respiratory quotient [RQ]) and cardiovascular disease risk factors (lipid profiles and blood pressure).胰岛素敏感性将通过经常采样静脉葡萄糖耐量测试（FSIGTT），骨骼肌中的甘油三酸酯含量和核磁共振光谱（1H-MRS）和肝脏中的肝脏含量来测量，并通过通风的Hood Hood Hood calorimetry来测量。

项目成果

Tobacco, Formula, and Frequent Pregnancies: The Obesity Trinity.

烟草、配方奶粉和频繁怀孕：肥胖三位一体。

• DOI: 10.1089/chi.2010.0406
• 发表时间: 2010
• 期刊: Childhood obesity (Print)
• 作者: Sothern,MelindaS

Feasibility of intravenous glucose tolerance testing prior to puberty.

青春期前静脉注射葡萄糖耐量测试的可行性。

• DOI: 10.3109/17477160903055937
• 发表时间: 2010
• 期刊: International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity
• 作者: Tompkins,ConnieL;Cefalu,William;Ravussin,Eric;Goran,Michael;Soros,Arlette;Volaufova,Julia;Vargas,Alfonso;Sothern,MelindaS
• 通讯作者: Sothern,MelindaS