Metabolic Syndrome--Prepubertal African Amer./Caucasian

代谢综合症——青春期前的非洲裔美国人/白种人

基本信息

批准号：
6875955
负责人：
MELINDA S SOTHERN
金额：
$ 39.79万
依托单位：
LSU HEALTH SCIENCES CENTER
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-05-16 至 2010-02-28
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Recent research indicates that the metabolic syndrome develops during childhood and is associated with several early risk factors including low (<= 10th percentile body mass index [BMI-USCDC]) or high (>= 90th percentile [BMI-USCDC]) birth weight. However, markers that precede the syndrome and mechanisms that explain these relationships have yet to be identified. These mechanisms may originate in the intrauterine environment, be exacerbated in susceptible populations, such as African Americans and, be further promoted by an early "obesigenic" environment. Thus, we propose that young African American children with low or high birth weight may be predisposed genetically and behaviorally to the early manifestation of subtle, non-symptomatic metabolic abnormalities that work synergistically to create a metabolic syndrome phenotype. The metabolic abnormalities increasing the propensity to type 2 diabetes may originate earlier than previously proposed. In adults insulin sensitivity is correlated negatively with lipid depots in the skeletal muscle (intramyocellular lipids = IMCL) and in the liver long before the development of diabetes. Noninvasive techniques for examining the relationship of skeletal muscle and liver lipids to insulin sensitivity have not been applied to prepubertal African American youth. How early and to what extent metabolic abnormalities occur in children and whether it is more prevalent in African American vs. Caucasian children are unknown. We therefore propose to: 1) Explore the potential markers and mechanisms of impaired insulin sensitivity in pre-pubertal (7-9 years) African American and Caucasian children with low or high birth weight. 2) Determine the relationship of birth weight and ethnicity to insulin sensitivity in these youth. We aim to explore potential markers and mechanisms of the impaired insulin sensitivity observed in 7-9 y prepubertal children by examining the relationships between insulin sensitivity and ectopic fat deposition i.e. triglyceride content in skeletal muscle and liver, abdominal fat (independent of ectopic fat), resting energy metabolism (REE and respiratory quotient [RQ] [fat oxidation] and cardiovascular disease risk factors lipid profiles and blood pressure). Insulin Sensitivity will be measured by Frequently Sampled Intravenous Glucose Tolerance Test (FSIGTT), triglyceride contents in skeletal muscle and liver by Nuclear Magnetic Resonance pectroscopy (ill-MRS) and energy metabolism by ventilated hood indirect calorimetry. A secondary aim is to examine he relationship of birth weight and ethnicity (African American vs. Caucasian) to insulin sensitivity in children, 7-9 years (with and without adjusting for total body fat and/or ectopic fat).

描述（由申请人提供）：最近的研究表明，代谢综合征在儿童时期发展，并且与早期的危险因素有关，包括低（<= <= 10％的体重指数[BMI-ISCDC]）或高（> = 90％[BMI-IUSCDC]）。但是，在综合征和解释这些关系的机制之前的标记尚未确定。这些机制可能起源于宫内环境，在易感人群中（例如非裔美国人）加剧，并通过早期的“青球菌”环境进一步促进。因此，我们建议在遗传和行为上可能会倾向于易于生育体重或高出生体重的年轻儿童，以早期表现出微妙的，无症状的代谢异常，这些异常在协同上起作用，以创造代谢综合征表型。代谢异常增加了2型糖尿病倾向的倾向可能比以前提出的要早。在成年人中，胰岛素敏感性与骨骼肌（细胞内脂质= IMCL）中的脂质仓库和肝脏中的脂质库有负相关。研究骨骼肌和肝脂质与胰岛素敏感性的关系的无创技术尚未应用于青春期前的非裔美国人青年。儿童的代谢异常发生在多大程度上，以及在非裔美国人与高加索儿童中是否更普遍。因此，我们建议：1）探索胰岛素前（7 - 9年）的非裔美国人和低出生体重或高出生体重的高加索儿童的胰岛素敏感性受损的潜在标记和机制。 2）确定这些年轻人的出生体重和种族与胰岛素敏感性的关系。我们的目的是通过检查胰岛素敏感性和异位脂肪沉积之间的关系，即骨骼肌和肝脏中的甘油三酸酯含量，腹部脂肪，腹部脂肪（无独立的能量脂肪）（REE EEE EEE [REE EE EEE [REE EE EE EE EE EE IDICITICTIENT]，[RESIDIDICTIENT] [RERIDIDICTIENT] [RE IDICITION IDICITINIC IDICITICTIENT [RRIDISICITICTIENT]，我们的目的是在7-9岁的青春期儿童中观察到的潜在标记和机制和机制。心血管疾病危险因素脂质特征和血压）。胰岛素敏感性将通过经常采样的静脉葡萄糖耐量测试（FSIGTT），骨骼肌中的甘油三酸酯含量和核磁共振辅助术和肝脏中的甘油三酸酯含量（ILL-MRS）和能量代谢代谢。第二个目的是检查出生体重和种族（非裔美国人与高加索人）与儿童胰岛素敏感性的关系，为7 - 9岁（有没有调整总体脂肪和/或异位脂肪）。