Molecular and Soc. Determinants of Obesity and Metabolic Disorders in Youth

分子与社会。

基本信息

批准号：
8718824
负责人：
MELINDA S SOTHERN
金额：
$ 42.86万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8718824
关键词：
Adipocytes Adipose tissue Adolescence Adult Age Alabama Anti-Inflammatory Agents Anti-inflammatory Antidiabetic Drugs Behavioral Behavioral Genetics Biological Biological Markers Blood Circulation Breast Feeding C-reactive protein Cardiovascular Diseases Central obesity Child Clinical Research Complex Complication Consumption Cross-Sectional Studies Deep South Deterioration Development Diagnosis Diet Disadvantaged Discipline Dyslipidemias Early Diagnosis Environment Environmental Exposure Exposure to Food Functional disorder Future Gender Genes Genetic Genetic Predisposition to Disease Glucose Health Health Sciences Hypertension Individual Inflammation Inflammation Mediators Inflammatory Instruction Insulin Resistance Interleukin-6 Lead Link Mediating Mediator of activation protein Mediterranean Diet Metabolic Metabolic Diseases Metabolic syndrome Modeling Molecular Molecular Genetics Morbidity - disease rate Neighborhoods Non obese Obesity Pathway interactions Physical activity Pregnancy Prevalence Production Property Prospective Studies Puberty Public Health Race Research Research Personnel Scientist Single Nucleotide Polymorphism Stress Time Tumor Necrosis Factor-alpha United States Universities Weight Youth adipokines adiponectin allostatic load base cohort contextual factors fruits and vegetables health disparity inflammatory marker innovation maternal stress obesity in children obesity risk outcome forecast prepuberty prevent psychologic social social health determinants social stress stressor

项目摘要

Obesity is recognized as the essential component of the metabolic syndrome, a pro-inflammatory state characterized by biomarkers of dyslipidemia, hypertension, central obesity, and elevated glucose. Scientists tend to identify only the genetic and behavioral antecedents of this pro-inflammatory state. Conversely, social and psychological researchers recognize a similar construct, allostatic load, also characterized by similar biomarkers. Differential environmental exposure to social stressors, i.e., allostatic load may lead to the pro-inflammatory state associated with metabolic syndrome . The challenge is to understand the link between obesity, metabolic and immunological abnormalities, and social stress. Recent research in adults indicates an increase in adiponectin after consumption of a Mediterranean diet high in fruits and vegetables. Consequently, greater access to fresh fruits and vegetables may contribute to increased adiponectin, reduced inflammation and a lower risk of obesity and metabolic disease. Our previous cross-sectional studies acknowledge that metabolic and pro-inflammatory mediators are over-expressed in youth prior to puberty. Prospective studies in developing children are proposed here to delineate the time course of obesity and metabolic dysfunction in relation to pro and anti-inflammatory markers. Correlating the molecular basis of obesity, one of the primary health disparities in the Deep South, with social determinants of health, e.g. maternal stress, neighborhood deterioration, food and physical activity environment and behavioral factors, e.g. diet and physical activity, assumes a complex, multidimensional effort involving a range of disciplines. Thus, in a multi-ethnic cohort of healthy youth we propose to; I. Examine the relationship of pro-and-antinflammatory SNPs with change in obesity and related metabolic biomarkers from pre-to-post-adolescence and further determine the mediating effect of the change in inflammatory markers during this same time period, II. Examine the contribution of social determinants (stress, food and physical activity environment) to the change in obesity, metabolic health and inflammation from pre-to-post adolescence after considering race, gender, maternal pregnancy weight, breastfeeding duration, diet and physical activity.

肥胖被认为是代谢综合征的重要组成部分，促炎状态以血脂异常，高血压，中枢肥胖和葡萄糖升高的生物标志物为特征。科学家倾向于仅确定这种促炎状态的遗传和行为前因。反过来，社会和心理学研究人员认识到类似的结构，同种异体负荷，也以此为特征类似的生物标志物。环境差异暴露于社会压力源，即同性载荷可能导致与代谢综合征相关的促炎状态。挑战是了解链接肥胖，代谢和免疫学异常和社会压力之间。最新的成人研究表明食用高水果和蔬菜的地中海饮食后脂联素的增加。因此，更多获得新鲜水果和蔬菜的机会可能会导致脂联素增加，炎症减少，肥胖和代谢疾病的风险降低。我们以前的横截面研究承认，在青年之前，代谢和促炎性介体在青年中过表达青春期。在这里提出了对发展中儿童的前瞻性研究，以描述肥胖的时间过程与Pro和抗炎标记有关的代谢功能障碍。相关分子基础肥胖是深南部的主要健康差异之一，具有健康的决定因素，例如孕产妇的压力，邻里恶化，食物和体育锻炼环境和行为因素，例如饮食和体育锻炼，假定涉及一系列学科的复杂，多维的努力。因此，在多种族的健康年轻人中，我们建议； I.检查亲抗炎的关系肥胖和相关代谢生物标志物的SNP从前至青春期并进一步确定炎症标记变化的介导作用时期，ii。检查社会决定因素（压力，食物和体育锻炼环境）对考虑肥胖，代谢健康和炎症的变化种族，性别，产妇怀孕体重，母乳喂养持续时间，饮食和体育锻炼。