Genetic/Behavior/Lifestyle Risk-Diabetes Mexican-America

遗传/行为/生活方式风险-糖尿病墨西哥-美国

基本信息

批准号：
7055542
负责人：
JOSEPH MCCORMICK
金额：
$ 49.6万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-07-15 至 2007-03-14
项目状态：
已结题

项目摘要

Type 2 diabetes mellitus poses major health burdens for individuals, families, and populations. Particular populations appear to be especially vulnerable to type 2 diabetes (T2DM). Among these is the Mexican American population that bears a disproportionate burden of T2DM. This has doubled in the last 2 decades, and is likely to increase further with rapid population growth and aging of this relatively young population, and earlier onset of T2DM. There will be increasingly costly and debilitating consequences of complications of Type 2 diabetes in larger numbers of patients, and earlier in life than we have seen hitherto. While susceptibility to type 2 diabetes mellitus has long been known to have a substantial genetic component, we hypothesize that there are also genetic components of the various complications. Risk factors for these implications will also encompass a range of behavioral and life style components which are at presently ill-defined. Our existing program examines not only the genetic component, but also life style and socioeconomic factors associated with T2DM in the Hispanic population in a small cohort. These studies are currently limited by an insufficiently large population of participants who can be followed both for the evolution of their diabetes, as well as the complications arising as disease progresses. In particular we wish to expand our understanding beyond some of the social and behavioral components of disease progress, and in particular assess the contribution of anxiety and depression, which is little studied in Mexican Americans. To this end, we propose to expand the existing funded and approved cohort study we have established among the Mexican American population in the Lower Rio Grande Valley. We now have access to the sophisticated genome scanning studies which have proceeded rapidly and the human gene expression map is maturing. Our strategy is therefore to exploit the interaction of genomics with behavioral, socioeconomic and lifestyle measures to provide the most robust measures of the components which predispose and lead to T2DM and its complications. The identification of precise risk factors for T2DM and ts complications in a Mexican American cultural/gene interaction setting will be the most productive way to move from general to individual approaches to prevention of both disease and its many complications.

2 型糖尿病给个人、家庭和人群带来重大健康负担。特定人群似乎特别容易患 2 型糖尿病 (T2DM)。其中，墨西哥裔美国人承受着不成比例的 T2DM 负担。这一数字在过去 20 年中翻了一番，并且随着人口的快速增长、相对年轻的人口老龄化以及 T2DM 的提早发病，这一数字可能会进一步增加。与我们迄今为止所看到的相比，2 型糖尿病并发症在更多患者中造成的代价将越来越高，而且会导致患者衰弱。虽然人们早就知道 2 型糖尿病的易感性具有显着的遗传因素，但我们假设各种并发症也有遗传因素。这些影响的风险因素还包括一系列目前尚不明确的行为和生活方式组成部分。我们现有的计划不仅在一小群西班牙裔人群中检查遗传成分，还检查与 T2DM 相关的生活方式和社会经济因素。这些研究目前受到参与者人数不足的限制，这些参与者可以跟踪糖尿病的演变以及疾病进展引起的并发症。我们特别希望扩大我们对疾病进展的一些社会和行为组成部分的理解，特别是评估焦虑和抑郁的影响，这在墨西哥裔美国人中很少被研究。为此，我们建议扩大我们在下里奥格兰德河谷的墨西哥裔美国人中建立的现有资助和批准的队列研究。我们现在可以进行复杂的基因组扫描研究，这些研究进展迅速，人类基因表达图谱也日趋成熟。因此，我们的策略是利用基因组学与行为、社会经济和生活方式测量的相互作用，为易患和导致 T2DM 及其并发症的成分提供最强有力的测量。在墨西哥裔美国人的文化/基因相互作用环境中，确定 T2DM 和 ts 并发症的精确危险因素将是从一般方法转向个体方法以预防疾病及其多种并发症的最有效方法。