OTOREFLECTANCE ASSESSMENT OF MIDDLE-EAR FUNCTIONING

中耳功能的耳反射评估

• 批准号: 7056571
• 负责人: Douglas H Keefe
• 金额: $ 43.07万
• 依托单位: SONICOM, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-26 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7056571
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; clinical biomedical equipment; clinical research; conductive hearing loss; diagnosis design /evaluation; ear disorder diagnosis; hearing tests; human subject; middle ear; middle ear disorder; otitis media; patient oriented research; tympanum

DESCRIPTION (provided by applicant): Otoreflectance (OR) is a new class of hearing-test instruments utilizing acoustic signals presented and recorded in the ear canal. OR instruments address the following limitations in existing instruments to screen and diagnose middle-ear function: (1) detection of otitis media, (2) prediction of conductive hearing loss, (3) detection of middle-ear dysfunction in infants receiving a newborn hearing screening exam or follow-up audiologic assessment, and (4) general use to assess middle-ear function at frequencies in the bandwidth of speech. An OR test provides measurements over a wideband range (approximately 0.25 to 8 kHz) of such transfer functions as reflectance and admittance, and power absorbed by the ear canal and middle ear. Energy reflectance and absorbed power are OR functions that are relatively insensitive to probe position in the ear canal, and thus are well suited to interpreting middle-ear function at higher frequencies. One type of OR instrument can be used with probes similar to otoacoustic emission probes to screen middle-ear function in several seconds at ambient ear-canal pressure. Phase I of this project established the feasibility of measuring such OR responses in normal-hearing adults and children, as well as in children with surgically confirmed middle-ear fluid. Phase I also implemented a wideband OR test to assess the function of the middle-ear muscle reflex, and compared reflex thresholds in infants and adults with thresholds measured using conventional instruments. In Phase II, a wideband OR tympanometry instrument will be implemented, adding a pump to vary ear-canal static pressure, and OR tympanometry norms will be measured in adults. The test performance of ambient-pressure OR and conventional 226-Hz tympanometry will be compared in young children to detect middle-ear fluid and to predict a conductive hearing loss associated with otitis media with effusion. OR tympanometry will form part of a new objective and efficient wideband test to measure middle-ear muscle reflex thresholds, which will be compared to thresholds in adults and infants measured using a conventional test. The test performance of the ability of OR tympanometry, ambient-pressure OR, and conventional 1000-Hz tympanometry to detect middle-ear dysfunction will be compared in infants also receiving a standard newborn hearing screening exam. Outcomes from Phase II will evaluate whether OR is more accurate than conventional tests to screen and diagnose middle-ear dysfunction in clinical applications of important societal concern.

描述（由申请人提供）：otorefrofectance（OR）是使用耳道中呈现和记录的声学信号的新的听力测试仪器。或仪器解决现有工具中的以下限制，以筛选和诊断中等级别的功能：（1）检测中耳炎培养基，（2）预测导电性听力损失的预测，（3）在接受新生儿听力筛查或后续听觉评估的婴儿中检测中性功能障碍，以及（4）评估中等函数的常见语音功能。或测试可在宽带范围内（约0.25至8 kHz）的转移功能进行测量，例如反射率和入场，并被耳道和中耳吸收的功率。能量反射率和吸收功率是对探针位置在耳道中的位置相对不敏感的功能，因此非常适合在较高频率下解释中耳功能。一种类型的或仪器可以与类似于耳声发射探针类似的探针使用，以在环境耳机压力下几秒钟内筛选中耳功能。该项目的第一阶段确定了在正常听力的成年人和儿童以及手术确认的中耳液中测量或反应的可行性。第一阶段还实施了宽带或测试来评估中耳肌肉反射的功能，并将婴儿和成人的反射阈值与使用常规仪器测量的阈值进行了比较。在II期中，将实施宽带或鼓膜测定仪器，将泵添加到不同的耳朵静态压力中，并且将在成人中测量鼓膜的静态测定仪。在幼儿中，将比较环境压力或常规226 Hz鼓膜的测试性能，以检测中耳液，并预测与中耳炎介质相关的导电性听力损失。或鼓膜法将构成一个新的客观和有效的宽带测试的一部分，以测量中耳肌肉反射阈值，这将与使用常规测试测量的成人和婴儿的阈值进行比较。在婴儿的婴儿中，还将比较接受标准的新生儿听力筛查检查的婴儿，将比较开发能力或鼓膜的能力，环境压力或传统1000 Hz鼓膜测试的测试性能。第二阶段的结果将评估是否比常规测试更准确，以筛选和诊断重要社会关注的临床应用中的中耳功能障碍。