ACOUSTIC RESPONSES OF COCHLEA AND MIDDLE EAR

耳蜗和中耳的声学响应

• 批准号: 6176908
• 负责人: Douglas H Keefe
• 金额: $ 25.28万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6176908
• 关键词: auditory stimulus; clinical research; cochlea; ear disorder diagnosis; hearing; hearing disorders; hearing tests; human subject; mathematical model; middle ear; noninvasive diagnosis; otoacoustic emission; statistics /biometry

DESCRIPTION (From applicant's proposal): The main theme of the proposed research is to increase our knowledge of the human middle ear and cochlea based upon the use of acoustic response testing in the ear canal. Such tests are inherently noninvasive so that it is hoped that the knowledge gained on basic mechanisms in hearing will have significance for clinical utilization. The first aim is to examine new forms of otoacoustic emissions (OAE), which will provide a clearer understanding of mechanical processes on the basilar membrane. Time-frequency representations of OAE transients will delineate the fine structure of the tonotopically organized cochlear dynamics, which is otherwise partially obscured by conventional waveform or spectral representations. The second aim is to assess middle-ear and cochlear mechanisms in an integrated manner using a power-transfer approach. Such an approach will combine aspects of wideband tympanometry, otoreflectance and OAE measurements to interpret power flow from the ear canal through the middle ear to the cochlea, and back. The third aim will apply these new types and representations of OAEs and the power-transfer approach in large-scale studies of normal ears, and ears with middle-ear and cochlear impairments. The goal is to improve techniques to predict conductive, cochlear and mixed hearing losses, and to better understand how acoustic response variables can be combined, for example, across frequency or static pressure in the ear canal, in order to understand the underlying cochlear and middle-ear mechanics and coupling in normal and impaired ears. The results of the proposed experiments will provide useful data for theoretical modeling of the auditory periphery, and could significantly improve our ability to identify persons with conductive or cochlear hearing loss.

描述（来自申请人的提议）：拟议研究的主题是根据在耳道中使用声学反应测试来提高我们对人类中耳和耳蜗的了解。这种测试本质上是无创的，因此希望在听力基本机制上获得的知识对临床利用具有重要意义。第一个目的是检查耳声排放（OAE）的新形式，这将为基底膜上的机械过程提供更清晰的理解。 OAE瞬变的时频表示将描绘出有组织的人工耳蜗动力学的精细结构，否则该动态被传统的波形或光谱表示部分掩盖。第二个目的是使用功率转移方法以综合方式评估中耳和耳蜗机制。这样的方法将结合宽带鼓膜，耳构和OAE测量的各个方面，以解释从耳道到中耳到耳蜗的功率流，然后再向后。第三个目标将在对正常耳朵的大规模研究中应用这些新类型和表征和电力转移方法，并具有中耳和耳蜗障碍的耳朵。目的是改善技术来预测导电性，人工耳蜗和混合听力损失，并更好地理解如何将声学响应变量（例如在耳道中的频率或静压）中组合在一起，以了解正常和障碍的耳朵中的潜在的耳蜗和中等耳蜗和耦合。拟议的实验的结果将为听觉外围的理论建模提供有用的数据，并可以显着提高我们识别有导电或耳蜗听力损失的人的能力。