ACOUSTIC RESPONSES OF COCHLEA AND MIDDLE EAR

耳蜗和中耳的声学响应

• 批准号: 6634486
• 负责人: Douglas H Keefe
• 金额: $ 27.84万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6634486
• 关键词: auditory stimulus; clinical research; cochlea; ear disorder diagnosis; hearing; hearing disorders; hearing tests; human subject; mathematical model; middle ear; noninvasive diagnosis; otoacoustic emission; statistics /biometry

DESCRIPTION (From applicant's proposal): The main theme of the proposed research is to increase our knowledge of the human middle ear and cochlea based upon the use of acoustic response testing in the ear canal. Such tests are inherently noninvasive so that it is hoped that the knowledge gained on basic mechanisms in hearing will have significance for clinical utilization. The first aim is to examine new forms of otoacoustic emissions (OAE), which will provide a clearer understanding of mechanical processes on the basilar membrane. Time-frequency representations of OAE transients will delineate the fine structure of the tonotopically organized cochlear dynamics, which is otherwise partially obscured by conventional waveform or spectral representations. The second aim is to assess middle-ear and cochlear mechanisms in an integrated manner using a power-transfer approach. Such an approach will combine aspects of wideband tympanometry, otoreflectance and OAE measurements to interpret power flow from the ear canal through the middle ear to the cochlea, and back. The third aim will apply these new types and representations of OAEs and the power-transfer approach in large-scale studies of normal ears, and ears with middle-ear and cochlear impairments. The goal is to improve techniques to predict conductive, cochlear and mixed hearing losses, and to better understand how acoustic response variables can be combined, for example, across frequency or static pressure in the ear canal, in order to understand the underlying cochlear and middle-ear mechanics and coupling in normal and impaired ears. The results of the proposed experiments will provide useful data for theoretical modeling of the auditory periphery, and could significantly improve our ability to identify persons with conductive or cochlear hearing loss.

描述（来自申请人的提案）：拟议研究的主题是基于在耳道中使用声学响应测试来增加我们对人类中耳和耳蜗的了解。此类测试本质上是非侵入性的，因此希望获得的有关听力基本机制的知识对临床应用具有重要意义。第一个目标是检查新形式的耳声发射（OAE），这将使人们更清楚地了解基底膜上的机械过程。 OAE 瞬态的时频表示将描绘按音调组织的耳蜗动力学的精细结构，否则传统波形或频谱表示会部分掩盖该结构。第二个目标是使用功率传输方法以综合方式评估中耳和耳蜗机制。这种方法将结合宽带鼓室导抗测试、耳反射和 OAE 测量的各个方面，以解释从耳道通过中耳到耳蜗并返回的功率流。第三个目标是将这些 OAE 的新类型和表示以及功率传输方法应用于正常耳朵以及中耳和耳蜗损伤的耳朵的大规模研究中。目标是改进预测传导性听力损失、耳蜗听力损失和混合性听力损失的技术，并更好地了解如何组合声学响应变量，例如跨频率或耳道静压，以便了解底层的耳蜗和中耳听力损失。 -正常耳朵和受损耳朵的耳朵力学和耦合。所提出的实验结果将为听觉外围的理论建模提供有用的数据，并可以显着提高我们识别传导性或耳蜗性听力损失者的能力。