AGRICULTURAL DUST AND CHILDHOOD ASTHMA SYMPTOMS

农业灰尘和儿童哮喘症状

• 批准号: 6727487
• 负责人: Steven B Wing
• 金额: $ 10.74万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6727487
• 关键词: adolescence (12-20); agriculture; air pollution; airborne allergen; asthma; clinical research; environmental exposure; human subject; pollution related respiratory disorder; respiratory disorder epidemiology

DESCRIPTION (provided by applicant): The proposed study will assess the relationship between exposure to industrial livestock operations and the prevalence of asthma-related symptoms among 7TH and 8TH grade students attending public schools in North Carolina. During the 1999-2000 school year, the North Carolina Department of Health and Human Services conducted a statewide population-based survey of middle school students in order to assess the prevalence of asthma-related symptoms, medication use, barriers to adequate medication use, and behavioral consequences of the reported symptoms. This application seeks to extend the benefit and utility of the statewide survey by exploring the relationship between the prevalence of asthma symptoms among surveyed students and exposure to agricultural airborne pollutants experienced during school hours. School-based exposure will be estimated using an extensive database of industrial livestock operations, including information about the size, type of animals, geographic location, and waste management practices. Exposure estimates will be supplemented with information provided about the school environment, including air-conditioning, mold, odor, and other school-building characteristics. Epidemiologic analyses will focus on the association between the prevalence of asthma-related symptoms and exposure estimates. The specific aims of this study are: (1) to estimate exposure to airborne emissions from industrial livestock operations at public middle schools using spatial analysis of the following measurements: (a) distance from the livestock operation to the middle school, (b) steady state live weight of all animals in livestock operations surrounding a given middle school, and (c) information obtained from school personnel about odor, environmental, and physical conditions at the schools; (2) to determine whether students' risk of asthma-related symptoms is related to the distance to the nearest industrial livestock operation, quantity of animals near the school, and school-based exposure to industrial livestock; and (3) to evaluate the distribution of asthma-related symptoms and exposures within geographic, racial, and socio-economic categories to determine whether the frequency and severity of symptoms and livestock exposures most heavily burden specific subpopulations of students.

描述（由申请人提供）：拟议的研究将评估接触工业牲畜行动的关系与北卡罗来纳州公立学校的7年级和8年级学生之间与哮喘相关症状的患病率之间的关系。在1999-2000学年期间，北卡罗来纳州卫生与公共服务部对中学学生进行了基于全州人群的调查，以评估与哮喘相关症状的患病率，使用药物使用，充足的药物使用障碍以及报告症状的行为后果。该申请旨在通过探索被调查的学生中哮喘症状的患病率与在上课时间经历的农业空气传播污染物之间的关系之间的关系来扩大全州调查的利益和效用。基于学校的接触将使用广泛的工业牲畜操作数据库进行估算，包括有关大小，动物类型，地理位置和废物管理实践的信息。接触估计将补充有关学校环境的信息，包括空调，霉菌，气味和其他校造特征。流行病学分析将集中于与哮喘相关症状的患病率与暴露估计的关联。这项研究的具体目的是：（1）估算公立中学工业牲畜行动中的空降排放量使用以下测量的空间分析：（a）从牲畜行动到中学到中学的距离，（b）（b）（b）所有动物的稳态稳态生活体重在给定的中学和（c）cripplion corvertrict crespription corvernal和c）环境中的信息，以及（c）环境中的信息。 （2）确定学生患哮喘相关症状的风险是否与与最近的工业牲畜行动，学校附近的动物数量以及基于学校的工业牲畜的距离有关； （3）评估地理，种族和社会经济类别中与哮喘相关症状和暴露的分布，以确定症状和牲畜暴露的频率和严重性是否会导致学生的负担最严重。