SEX DIFFERENCES IN SLEEP REGULATION IN DEPRESSION

抑郁症睡眠调节的性别差异

• 批准号: 6782624
• 负责人: ROSEANNE ARMITAGE
• 金额: $ 43.05万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6782624
• 关键词: age difference; behavioral /social science research tag; brain electrical activity; disease /disorder proneness /risk; electroencephalography; female; gender difference; human middle age (35-64); human subject; major depression; male; patient oriented research; sleep; sleep deprivation; women' s health; young adult human (21-34)

Depression is a pervasive psychiatric disease with significant associated personal, economic and medical costs. Despite evidence that the pathophysiology of depression differs for men and women, the mechanisms underlying these sex differences are unknown. This study will investigate homeostatic regulation of slow-wave activity (SWA) in EEG at baseline and in response to a 3-hour sleep delay in symptomatic depressed men and women and age- and gender-matched healthy controls. The long- range objective of this work is to determine the independent and interactive influence of sex and disease on sleep regulation and to understand the biological basis for sex differences in the pathophysiology, symptoms and relative risks for depression. The primary specific aims are: 1) To evaluate sex differences in the regulation of slow-wave activity (SWA) during sleep in response to a 3 hour sleep delay in 80 depressed men and women (n=40/group), 20-40 years of age. 2) To evaluate sex differences in the regulation of SWA in response to a 3 hour sleep delay in 80 healthy men and women (n=40/group), 20-40 years of age. 3) To confirm that the magnitude of sex differences in the regulation of SWA is larger in depressed patients than in healthy adults i.e. the group by sex interaction. The secondary aims include:4) To begin to establish the initial age-related changes in the regulation of SWA and to determine if the maturational time course differs by sex and disease. 5) To explore sex- and disease-dependent influences on the relationship between objective sleep physiology and subjective sleep characteristics. It is hypothesized that both depressed men and women will show homeostatic abnormalities, but it will be hyper-responsivity in women and hypo-responsivity in men. It is suggested that both conditions arise from sex-dependent propensities toward organizational abnormality observable only under challenge conditions in healthy individuals.

抑郁症是一种普遍存在的精神病，具有显着相关的个人，经济和医疗费用。尽管有证据表明抑郁症的病理生理因男性和女性有所不同，但这些性别差异的基础机制尚不清楚。 这项研究将调查基线时EEG慢波活动（SWA）的体内平稳调控，并响应有症状的男性和女性和年龄和性别匹配的健康对照的3小时睡眠延迟。 这项工作的长距离目标是确定性别和疾病对睡眠调​​节的独立和互动影响，并了解病理生理学，症状和抑郁症相对风险的性别差异的生物学基础。主要的特定目的是：1）评估睡眠期间慢波活动（SWA）的性别差异，以响应80个抑郁症的男女（n = 40/组）（20-40岁）的3小时睡眠延迟。 2）评估SWA调节中的性别差异，以响应80名健康男女（n = 40/组）的3小时睡眠延迟，20-40岁。 3）确认，在抑郁症患者中，SWA调节中性别差异的大小要比健康的成年人，即通过性别相互作用。次要目的包括：4）开始建立SWA调控的初始年龄相关的变化，并确定成熟时间过程是否因性别和疾病而有所不同。 5）探索性和疾病依赖性的影响对客观睡眠生理与主观睡眠特征之间关系的影响。假设沮丧的男人和女性都会表现出体内稳态异常，但这将是女性的高反应性和男性低反应性。 有人认为，这两种情况都是由仅在健康个体的挑战条件下观察到的性别依赖性倾向才能观察到的组织异常。