CHILDHOOD DEPRESSION--PHYSIOLOGICAL CORRELATES

童年抑郁症——生理相关性

• 批准号: 2760415
• 负责人: ROSEANNE ARMITAGE
• 金额: $ 32.11万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-15 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2760415
• 关键词: adolescence (12-20); biomarker; brain interhemispheric activity; child (0-11); clinical depression; clinical research; depression; electroencephalography; gender difference; human subject; sleep

This study will establish whether sleep EEG dysregulation (low inter- and intrahemispheric coherence) is a reliable feature of childhood and adolescent depression, contrasting symptomatic and remitted children and adolescents with age- and gender-matched normal controls. The long range objective of identifying reliable biological features of depression is to improve on differential diagnosis, prognostication, and treatment selection. Of particular relevance to this application is the additional potential to identify patients prior to the clinical expression of the illness in order to ultimately intervene to prevent the onset of illness. The specific aims are: 1) To establish which sleep EEG coherence measures are significantly lower in those with childhood depression (n=50) compared to age- and gender-matched health controls (n=50). 2) To establish which sleep EEG coherence measures are significantly lower in those with adolescent depression (n=50) compared to age- and gender-matched healthy controls (n=50). 3) To fully explore gender differences in sleep EEG coherence measures in the total sample of depressed (n=100) and control (n=100) and control (n=100) subjects. Equal numbers of males and females will be included in the total sample. We expect that gender differences will be evidence in adolescents with MDD. 4) To explore state-train characteristics of low-inter and intrahemispheric coherence in depressed children and adolescents. 5) A sub-aim is to evaluate the developmental time course of sleep EEG coherence in the 100 healthy controls as a means of determining how high inter- and intrahemispheric coherence measures are influenced by brain maturation. 6) To establish the relationship between sleep micro- and macro- architecture in childhood and adolescent MDD.

这项研究将确定睡眠脑电图失调（低膜间和膜内相干性）是否是儿童期和青少年抑郁症的可靠特征，对比对比的儿童和青少年，具有年龄和性别匹配的正常对照。鉴定抑郁症的可靠生物学特征的远距离目标是改善鉴别诊断，预后和治疗选择。与本应用特别相关的是在疾病临床表达之前识别患者的其他潜力，以最终干预以防止疾病发作。具体目的是：1）与年龄和性别匹配的健康控制（n = 50）相比，儿童抑郁症患者（n = 50）的患者（n = 50）的脑电图相干度量明显降低（n = 50）。 2）与年龄和性别匹配的健康对照组相比，青少年抑郁症患者（n = 50）的患者（n = 50）的脑电图（n = 50）明显降低。 3）在抑郁症（n = 100）和对照（n = 100）和对照（n = 100）受试者的总样本（n = 100）和对照组（n = 100）的总样本中，探索睡眠脑电图相干度量的性别差异。总样本中将包括相等数量的男性和女性。我们预计性别差异将是MDD青少年的证据。 4）探索抑郁症儿童和青少年中低区域和骨内相干性的状态训练特征。 5）一个子aim是评估100个健康对照中睡眠脑电图相干性的发育时间过程，以确定脑部成熟度高度和骨内相干性测量的高度。 6）建立童年和青少年MDD的睡眠微观和宏观建筑之间的关系。