Sleep Homeostasis in Adolescent Depression

青少年抑郁症的睡眠稳态

• 批准号: 7591854
• 负责人: ROSEANNE ARMITAGE
• 金额: $ 36.1万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7591854
• 关键词: 18 year old; Acceleration; Adolescence; Adolescent; Adult; Age; Age of Onset; Biological; Characteristics; Childhood; Clinical; Data; Development; Disease; Electroencephalography; Feeling suicidal; Female; Female Adolescents; Functional disorder; Gender; Goals; Homeostasis; Hour; Intervention; Major Depressive Disorder; Male Adolescents; Measures; Medical Economics; Mental disorders; Moods; Physiology; Premature aging syndrome; Prevalence; Publishing; Recurrence; Regulation; Relapse; Relative Risks; Reporting; Research; Residual state; Risk; Risk Factors; Severities; Sex Characteristics; Sleep; Sleep disturbances; Staging; Surface; Symptoms; Testing; Time; Woman; Work; age related; base; boys; cost; depressed; depression; depressive symptoms; disorder control; early onset; emerging adult; girls; improved; interest; male; men; novel; prevent; psychobiologic; public health relevance; response; sex; sleep regulation; treatment response; young adult

DESCRIPTION (provided by applicant): Depression is a pervasive psychiatric disease with significant associated personal, economic and medical costs. Early onset depression in childhood or adolescence is associated with particularly high costs, as an earlier age of onset is associated with a worse clinical course. Relapse rates are extremely high in depressed adolescents (40-65 % within 1 year). Understanding the biological risks factors for depression and the underlying pathophysiology of the illness are essential to reducing the costs associated with the illness and the development of new strategies in treating early onset depression. Previous research has shown that slow wave activity (SWA) regulation is impaired in adults with major depressive disorders (MDD) but is strongly sex-dependent. Men with MDD show a blunted response to sleep challenge compared to healthy controls, whereas women with MDD show a hyper-response to challenge compared to healthy women. To date, there are no published studies of sleep regulation in early onset MDD. The proposed study will determine if impaired SWA homeostasis also characterizes adolescents with MDD. Of primary interest are age-related changes in SWA homeostasis to test the hypothesis that depression associated with premature aging and whether the time course differs in boys and girls with MDD. The proposed work will also begin to assess the relationship between homeostatic response to challenge and symptoms of depression and whether sleep challenge improves mood differentially in boys and girls. The long-range objectives of this work are to determine the independent and interactive influence of sex and disease on sleep regulation, to improve understanding of the biological bases for sex differences in the symptoms and relative risks for depression and to develop intervention strategies informed by this work to reduce the differential biological risk factors for depression in boys and girls. The specific aims of this proposal are: 1. to evaluate slow-wave activity (SWA) in baseline sleep in 72 mature (Tanner Stage 5) depressed adolescent males and females (n=36/group) and 72 age- and gender-matched healthy non-depressed controls (HCs) 2. To evaluate sex differences in the regulation of SWA in response to a 3 hour sleep delay in depressed adolescents compared to HCs. 3. To compare age-related changes in SWA response to sleep-delay across group and sex. 4. To determine the relationship between clinical features of depression and SWA regulation to assess whether the most impaired SWA is associated with a worse clinical course and higher suicidal ideation and if mood improves with homeostatic challenge. PUBLIC HEALTH RELEVANCE: The proposed research is of very high public health relevance. Sleep disturbances are core features of depression and are among the most common residual symptoms of depression. By identifying whether sleep homeostasis is abnormal in early onset depression, we can begin to develop novel interventions that specifically target sleep and are likely to reduce residual symptoms and may reduce risk of relapse and recurrence.

描述（由申请人提供）：抑郁症是一种普遍的精神病，具有显着相关的个人，经济和医疗费用。童年或青春期的早期发作抑郁症与成本特别高有关，因为较早的发病年龄与临床病程较差有关。抑郁症的青少年（1年内40-65％）的复发率极高。了解抑郁症的生物风险因素和疾病的潜在病理生理学对于降低与疾病相关的成本以及在治疗早期抑郁症的新策略的发展至关重要。先前的研究表明，重度抑郁症（MDD）的成年人慢波活动（SWA）调节受损，但性别依赖性很大。与健康对照相比，患有MDD的男性对睡眠挑战表现出钝性的反应，而患有MDD的女性与健康女性相比表现出对挑战的超反应。迄今为止，还没有关于早期发作MDD的睡眠调节的已发表研究。拟议的研究将确定SWA稳态受损是否也表征了MDD的青少年。主要感兴趣的是与年龄相关的SWA体内平衡的变化，以检验以下假设，即与过早衰老有关的抑郁症以及MDD男孩和女孩的时间过程是否有所不同。拟议的工作还将开始评估稳态对挑战症状和抑郁症状之间的关系，而睡眠挑战是否会差异地改善男孩和女孩的情绪。这项工作的远程目标是确定性别和疾病对睡眠调​​节的独立和互动影响，以提高对症状性别差异和抑郁症相对风险的生物学基础的理解，并制定这项工作所告知的干预策略，以减少男孩和女孩抑郁症的不同生物学风险因素。该提案的具体目的是：1。在72个成熟（坦纳阶段5）中评估基线睡眠中的慢波活动（SWA），青少年男性和女性（n = 36/组）和72岁的年龄和性别比较的健康不抑制对照（HCS）2。评估SWA响应的措施，以使SWA的性别差异为3个小时，以使SWA的性别差异为3个小时。 3。比较与年龄相关的变化，SWA对跨性别和性别的睡眠延期的反应变化。 4。确定抑郁症的临床特征与SWA调节之间的关系，以评估最受损的SWA是否相关 随着临床过程和更高的自杀念头，如果情绪在稳态挑战方面有所改善。 公共卫生相关性：拟议的研究具有很高的公共卫生相关性。睡眠障碍是抑郁症的核心特征，是抑郁症最常见的残留症状之一。通过确定睡眠稳态在早期抑郁症中是否异常，我们可以开始开发新的干预措施，这些干预措施专门针对睡眠，可能会减轻残留症状，并可能降低复发和复发的风险。