Cognitive Training Gains and Mobility Outcomes in ACTIVE

ACTIVE 中的认知训练收益和行动能力成果

• 批准号: 6821305
• 负责人: KARLENE K BALL
• 金额: $ 6.53万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6821305
• 关键词: accident proneness; behavioral /social science research tag; body movement; clinical research; cognition; cognitive behavior therapy; health care service utilization; health services research tag; human data; human old age (65+); human therapy evaluation; neural information processing; outcomes research; quality of life; vehicular accident

DESCRIPTION (provided by applicant): This application proposes secondary analyses of the mobility outcome measures from the data set collected through the clinical trial entitled Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE). The ACTIVE trial was a rigorously designed and conducted study that addressed an important question not previously investigated on a large scale, i.e., whether training effects on cognitive abilities resulted in improved or maintained function in daily activities. Even though there is substantial evidence that many basic cognitive abilities and processes are related to measures of functional status, need for care, and quality of life, few studies have addressed whether improving such cognitive function might have short- or long-term effects on daily activities related to living independently. Interventions designed to delay or prevent the need for use of nursing homes, home care, and short stay hospitals can save health-care costs, while also ensuring the independence and dignity of the aging population. Because of its size and the carefully developed rigor, the ACTIVE datasets offer investigators a wealth of opportunities for secondary analyses. The purpose of the analyses proposed here is to answer a range of questions not addressed in the original funding cycle, but which may be addressed by this data set. Specifically, this application seeks to 1) Determine the associations between cognitive measures in the ACTIVE screening battery and a range of mobility outcome measures (including crash risks, falls, life space, etc.) after adjusting for demographic and other relevant personal characteristics, 2) Examine the impact of the three cognitive interventions on these same mobility outcome measures, 3) Examine the associations between mobility measures and other secondary outcomes such as quality of life and health service utilization, and 4) Evaluate the mediating role of intervention effectiveness on mobility outcomes.

描述（由申请人提供）：本申请建议对通过题为独立和重要老年人高级认知训练（ACTIVE）的临床试验收集的数据集的活动结果测量进行二次分析。 ACTIVE 试验是一项经过严格设计和实施的研究，解决了一个以前没有大规模研究过的重要问题，即训练对认知能力的影响是否会导致日常活动功能的改善或维持。尽管有大量证据表明许多基本认知能力和过程与功能状态、护理需求和生活质量的衡量标准有关，但很少有研究探讨改善这种认知功能是否会对日常生活产生短期或长期影响。与独立生活相关的活动。旨在延迟或防止使用疗养院、家庭护理和短期医院的干预措施可以节省医疗费用，同时也确保老龄化人口的独立和尊严。由于其规模和精心开发的严谨性，ACTIVE 数据集为研究人员提供了大量进行二次分析的机会。这里提出的分析的目的是回答原始融资周期中未解决但该数据集可以解决的一系列问题。具体来说，本申请旨在 1) 在调整人口统计和其他相关个人特征后，确定 ACTIVE 筛查电池中的认知测量与一系列行动结果测量（包括碰撞风险、跌倒、生活空间等）之间的关联，2) 检查三种认知的影响对这些相同的流动性结果指标进行干预，3) 检查流动性指标与其他次要结果（例如生活质量和卫生服务利用）之间的关联，以及 4) 评估干预效果对流动性结果的中介作用。