Development of sensorimotor integration in children

儿童感觉运动整合的发展

• 批准号: 7103015
• 负责人: FLORIAN A KAGERER
• 金额: $ 7万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7103015
• 关键词: age difference; auditory pathways; behavioral /social science research tag; body movement; brain mapping; clinical research; computer data analysis; developmental neurobiology; eye movements; hand; head movements; human subject; middle childhood (6-11); neural information processing; preschool child (1-5); psychomotor function; sensorimotor system; visual pathways; young adult human (21-34)

DESCRIPTION (provided by applicant): The overall long-term objective of this research program is to understand the development of internal models or representations that underlie sensorimotor behavior. Previous research suggests that so-called sensorimotor internal models, or maps, are the basis for the control of target-directed movements. These maps can be conceptualized as computational transformations of eye- (for vision) or head-centered (for audition) coordinate frames to neural commands controlling the effector e.g. in hand-centered coordinates. To date, studies about the development of sensorimotor maps, and their interactions are lacking. Specific aim 1 is to determine the characteristics of the development of either kinesthetic-motor or auditory-motor internal representations (intramodal condition). Specific aim 2 is to determine the development of either kinesthetic-visuo-motor or auditory-visuo-motor internal representations (intermodal condition) in 5 to 10 year old children. A neural basis for interactions of internal models of different modalities is suggested in the posterior parietal cortex, where neurons have been shown to code both visual and auditory signals and map them onto hand-centered coordinates. These experiments will allow determination of the characteristics of intra- and intermodal motor map differentiation, and to obtain a developmental landscape of these characteristics. The PIs hypothesize that (1) intramodal motor representations are very broadly tuned in young children, resulting in considerable performance variability; (2) with increasing age, these internal representations become better 'tuned'; and (3) in intermodal contexts the less well-defined (intramodal) sensorimotor representations are more susceptible to being affected by better defined internal models. This is supported by preliminary results showing stronger auditory-motor aftereffects after a visuo-motor adaptation condition in young children than in older children, who are likely to have better-tuned intramodal sensorimotor models. The overall significance of the work proposed lies in addressing two knowledge gaps that stand in the way of having better insights into how sensorimotor representations develop and interact in children. Understanding this is an essential foundation for future work on developmental motor impairments such as developmental coordination disorder (DCD).

描述（由申请人提供）：该研究计划的总体长期目标是了解感官行为的内部模型或表示形式的发展。先前的研究表明，所谓的感觉运动内部模型或地图是控制目标指导运动的基础。这些地图可以概念化为眼睛（视觉）的计算转换，或以头部为中心的（试听）坐标框架，以控制效应器的神经命令，例如以手动为中心的坐标。迄今为止，缺乏有关感觉运动图及其相互作用的研究。具体目的1是确定动力学运动或听觉运动内部表示的发展的特征（安装内条件）。具体目的2是确定5至10岁儿童中动力学 - visuo-Motor或听觉 - Visuo-Motor内部表示（跨模式条件）的发展。在后顶层皮层中提出了不同模态内部模型相互作用的神经基础，该神经元已被证明可以对视觉和听觉信号进行编码，并将其映射到手工中心的坐标上。这些实验将允许确定内形运动图分化的特征，并获得这些特征的发育景观。 PIS假设（1）在幼儿中对（1）室内运动表示非常广泛地调节，导致了很大的性能变异性； （2）随着年龄的增长，这些内部表示形式变得更好“调整”； （3）在模式上下文中，明确定义的感觉运动表示表示更容易受到更好定义的内部模型的影响。这是由初步结果支持的，表明年龄较大的儿童的视觉运动适应条件后，听觉运动后效应更强。这项工作的总体意义在于解决两个知识差距，这些知识差距以更好地了解感觉运动表征如何在儿童中发展和互动。了解这是未来在发育运动障碍（例如发育协调障碍（DCD））上工作的基础。