Environmental Effects On Fertility

环境对生育力的影响

• 批准号: 6837566
• 负责人: DONNA D. BAIRD
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6837566
• 关键词: caffeine; clinical research; contraceptives; corpus luteum; embryo implantation; environmental contamination; environmental exposure; estrogens; fertility; health surveys; hormone metabolism; human subject; interview; luteinizing hormone; mathematical model; menstrual cycle; obesity; ovary disorder; ovulation detection /prediction; ovulation time; personal log /diary; pregnancy loss; progesterone; questionnaires; smoking; urinalysis

Adverse effects on reproductive capacity can occur at every phase of the reproductive process from prenatal development, puberty, to time when conception is occurring and the pregnancy is developing. This research project includes several aspects of the reproductive process, but mostly focuses on factors affecting the ability to conceive and maintain the pregnancy through its first few weeks. The complex biological processes involved include gamete development and maturation, sperm transport through the female reproductive tract, fertilization, early development of the conceptus, implantation, and maintenance of the developing embryo/trophoblast. We have developed methods to estimate environmental effects on fecundability, defined as the per menstrual cycle probability of conceiving, and we have followed women with daily urinary hormone measurements through their pregnancy attempts and early pregnancies. The biological underpinnings of fertility can also influence general health, and we have considered the health effects of female hormones within the framework of this project. The general aims of the project are to 1) refine methods for studying fertility, 2) to provide basic data documenting normal fertility and early development of the conceptus, 3) to investigate the impact of exposures that perturb normal reproductive processes.

从产前发育，青春期到发生受孕和妊娠发展的时间，可能会发生对生殖能力的不利影响。该研究项目包括生殖过程的几个方面，但主要集中于影响在最初几周内构思和维持怀孕能力的因素。涉及的复杂生物学过程包括配子的发展和成熟，通过女性生殖道的精子运输，受精，概念的早期发育，植入和发展的胚胎/滋养细胞的维持。我们开发了估计环境对繁殖力的影响的方法，该方法定义为每月的受孕概率，并且我们跟随妇女每天通过怀孕的尝试和早期怀孕进行尿激素测量。生育能力的生物基础也会影响一般健康，我们考虑了该项目框架内女性激素的健康影响。 该项目的总体目的是1）精炼研究生育能力的方法，2）提供基本数据记录正常生育能力和概念的早期发展，3）研究扰动正常生殖过程的暴露的影响。