Epidemiology, genetics, and behaviors in a study of basal cell carcinoma

基底细胞癌研究中的流行病学、遗传学和行为

• 批准号: 8259190
• 负责人: Leah McArthur Ferrucci
• 金额: $ 1.58万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2012-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8259190
• 关键词: Accounting; Affect; Age-Years; Agreement; Alcohols; Area; Basal cell carcinoma; Beds; Behavior; Behavioral Genetics; Behavioral Sciences; Benign; Biological Markers; Biometry; Caffeine; Cancer Model; Cancer Research Project; Case-Control Studies; Catchment Area; Characteristics; Clinical; Confidence Intervals; Contraceptive Usage; Data; Data Analyses; Databases; Dermatologist; Dermatopathology; Development; Diagnosis; Enrollment; Environmental Exposure; Environmental Risk Factor; Epidemiologic Studies; Epidemiologist; Epidemiology; Family history of; Fellowship; Female; Fibrinogen; Genetic; Genetic Predisposition to Disease; Genetic Research; Goals; Health Care Costs; Health Knowledge, Attitudes, Practice; Incidence; Individual; Intake; Interview; Knowledge; Learning; Lesion; Logistic Regressions; Lotion; Malignant Neoplasms; Measures; Molecular; Mutation; Newly Diagnosed; Occupations; Odds Ratio; Oral Contraceptives; Participant; Patient Self-Report; Patients; Pattern; Persons; Phenotype; Population; Population Study; Postdoctoral Fellow; Prevention; Prevention program; Preventive Intervention; Primary Prevention; Psychologist; Public Policy; Quality of life; Questionnaires; Radiation; Recording of previous events; Research; Research Activity; Research Personnel; Risk; Risk Factors; Site; Skin; Skin Cancer; Skin Carcinoma; Skin tanning; Solar elastosis; Stable Populations; Structure; Subgroup; Sun Exposure; Susceptibility Gene; The Sun; Time; Tissues; Tobacco; Training; Translating; Tumor Tissue; UV Radiation Exposure; Ultraviolet B Radiation; Ultraviolet Rays; Validity of Self Report; Variant; Work; base; cancer epidemiology; cancer prevention; cost; early onset; epidemiologic data; genetic epidemiology; interest; lifestyle factors; multidisciplinary; racial and ethnic; residence; skills; statistics; sun protection; tumor; ultraviolet; young woman

DESCRIPTION (provided by applicant): Non-melanoma skin cancers, of which 80 percent are basal cell carcinomas (BCC), are the most common cancers in the US, with more than one million diagnoses annually. Data suggest increasing incidence of BCC tumors of the torso and in young women. In comparison to most other malignancies, thorough descriptive and analytic epidemiologic data are markedly deficient. Although early-onset cancers may be more genetically driven, this rapid increase suggests an environmental cause (in a genetically susceptible population) which has not yet been identified. There is also a need to evaluate the validity of self-reported ultraviolet (UV) radiation exposure, used in most epidemiologic studies of skin cancer, in relation to objective tissue/tumor biomarkers. I will focus on three research areas (1) assessing how self-reported measures of UV correlate with more objective measures of skin damage (solar elastosis) and molecular level tumor mutations; (2) investigating environmental/lifestyle factors (UV exposure, tanning bed use, and caffeine intake) in relation to BCC; and (3) describing and evaluating indoor and outdoor tanning behaviors ,attitudes, and knowledge to identify potential barriers to sun protection and sunless tanning. All analyses will be conducted in the Yale SPORE for Skin Cancer case-control study with a targeted enrollment of 500 newly diagnosed BCC cases and 500 controls (benign lesions) < 40 years of age. Participants complete an in- person interview based on a structured questionnaire, which elicits information on sociodemographic and anthropometric factors, solar/other radiation, sunless tanning, tobacco and alcohol, personal/family history of cancer, oral contraceptive use, and caffeine intake. I will calculate percent agreement, Kappa statistics, and Pearson correlation coefficients to compare self-reported measures to tissue/tumor biomarkers. To identifying risk factors, I will use unconditional logistic regression to estimate odds ratios and 95% confidence intervals for the independent association of the factors of interest on BCC. Finally, I will describe common attitudes, behaviors, and knowledge regarding tanning and sunless tanning in the study population and identify sociodemographic and clinical correlates. BCC is one of the most common cancers, so identifying new risk factors in an epidemiologic study can have a significant, but low-cost impact on primary prevention. Although BCC is treatable, individuals incur significant healthcare costs and decreased quality of life. With this research, I can assess the validity of epidemiologic measures of UV, evaluate new exposures that might explain the recent increase in BCC in younger individuals, and with comprehensive data on tanning attitudes, behaviors, and knowledge, my findings can be translated into preventive interventions.

描述（由申请人提供）：非黑色素瘤皮肤癌，其中80％是基底细胞癌（BCC），是美国最常见的癌症，每年诊断超过一百万。数据表明，躯干和年轻女性的BCC肿瘤发生率增加。与大多数其他恶性肿瘤相比，彻底的描述性和分析性流行病学数据明显缺乏。尽管早期发作的癌症可能是遗传驱动的，但这种快速增加表明尚未鉴定出的环境原因（在遗传易感人群中）。还需要评估与客观组织/肿瘤生物标志物有关的大多数流行病学研究中使用的自我报告的紫外线（UV）辐射暴露的有效性。我将重点关注三个研究领域（1）评估自我报告的紫外线测量与皮肤损伤（太阳弹性弹性）和分子水平肿瘤突变的更客观测量的相关性； （2）研究与BCC有关的环境/生活方式因素（紫外线暴露，晒黑床的使用和咖啡因摄入量）； （3）描述和评估室内和室外晒黑行为，态度和知识，以确定防晒和无阳光晒黑的潜在障碍。所有分析将在耶鲁孢子中进行皮肤癌病例对照研究，目标入学率为500个新诊断的BCC病例和500例对照（良性病变）<40岁。参与者完成了基于结构化问卷的人访谈，该调查表引起了有关社会人口统计学和人体测量学因素，太阳能/其他辐射，无阳光晒黑，烟草和酒精的信息，癌症的个人/家族史，口腔避孕药的使用以及咖啡因的进气。我将计算一致性百分比，KAPPA统计和Pearson相关系数，以将自我报告的措施与组织/肿瘤生物标志物进行比较。为了识别危险因素，我将使用无条件的逻辑回归来估计BCC感兴趣因素的独立关联的几率和95％的置信区间。最后，我将描述有关研究人群中关于晒黑和无阳光晒黑的常见态度，行为和知识，并确定社会人口统计学和临床​​相关性。 BCC是最常见的癌症之一，因此在流行病学研究中识别新的风险因素可能对初级预防产生重大但低成本的影响。尽管BCC是可以治疗的，但个人会产生巨大的医疗保健成本和生活质量下降。通过这项研究，我可以评估紫外线度量的流行病学测量有效性，评估可能解释年轻个体BCC最近增加的新暴露，以及有关晒黑态度，行为和知识的全面数据，我的发现可以转化为预防性。干预措施。