ENVIRONMENTAL EFFECTS ON FERTILITY

环境对生育力的影响

• 批准号: 6106669
• 负责人: DONNA D. BAIRD
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6106669
• 关键词: clinical research; diethylstilbestrol; embryo /fetus toxicology; environmental toxicology; epidemiology; estrogens; fertility; hormone metabolism; human subject; menstrual cycle; mercury poisoning; nitrous oxide; occupational hazard; ovary disorder; ovulation detection /prediction; ovulation time; progesterone; questionnaires

Summary of Work: The primary purpose of the project on fertility is to develop methods for identifying reproductive hazards. Ultimately, we are working toward developing methods for studying reproductive hazards in small populations so that localized exposures can be evaluated. First, we have developed questionnaire methods for measuring fertility using data on time to pregnancy, the number of noncontracepting menstrual cycles required to conceive. This measure can be the focus of epidemiologic studies of fertility or can be integrated into epidemiologic studies of other diseases such as breast cancer. Data from female dentists is being examined to study the relationship between mercury and nitrous oxide exposures and female reproduction. Data on fertility are also being collected in the Agricultural Health Study. These data will be available for an analysis of pesticide related effects and fertility in the fall of 1997. Our second approach focusses on developing biological markers of impaired ovarian function. We have begun by examining urinary metabolites of estrogen and progesterone. These have been measured in daily urine specimens from over 700 menstrual cycles from about 200 women. First, we developed a method for detecting day of ovulation using these urinary hormone data. Our ability to detect ovulation using this method was very good. Now we are developing methods for characterizing follicular development, luteal function, and hormonal factors associated with conception and pregnancy loss.

工作摘要：主要目的 生育项目是开发用于识别的方法 生殖危害。最终，我们正在努力 开发用于研究小型生殖危害的方法 种群可以评估局部暴露。首先，我们 已经开发了调查表方法，用于测量使用 关于怀孕的时间数据，非置换的数量 受孕需要月经周期。这个措施可以是 流行病学研究的重点，或可以融入 其他疾病（例如乳腺癌）的流行病学研究。数据 来自女性牙医正在研究以研究这种关系 在汞和氧化二氮之间和女性之间 生殖。关于生育能力的数据也正在收集 农业健康研究。这些数据将用于 1997年秋天，农药相关的作用和生育能力分析。 我们的第二种方法着重于开发的生物标记 卵巢功能受损。我们已经开始检查尿液 雌激素和孕酮的代谢产物。这些已经 以700多个月经周期的每日尿液标本测量 来自大约200名女性。首先，我们开发了一种检测方法 使用这些尿激素数据排卵日。我们的能力 使用这种方法检测排卵非常好。现在我们是 开发表征卵泡发育，黄体的方法 功能以及与概念和荷尔蒙因素有关 怀孕丧失。