UTERINE LEIOMYOMAS

子宫肌瘤

• 批准号: 6289978
• 负责人: DONNA D. BAIRD
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6289978
• 关键词: African American; blood lipid; cancer risk; clinical research; female; gonadotropins; human genetic material tag; human middle age (35-64); human subject; insulin; leiomyoma; neoplasm /cancer epidemiology; neoplasm /cancer genetics; racial /ethnic difference; uterus neoplasms

Summary of Work: We are conducting a study to estimate prevalence and risk factors for uterine fibroids (as detected by a standard transabdominal and transvaginal ultrasound examination) in black women compared to nonblacks aged 35-49. Uterine tissue from women having fibroids removed will be studied to identify hormonal charaacteristics, growth factors and genetic changes in the tissue that are associated with fibroid development. Data have been collected from approximately 1500 women randomly identified from 35-49 year old members of a health care plan that serves approximately equal numbers of blacks and whites. A telephone interview was used to collect information on demographic factors, medical history, dietary intake, reproductive history, life style factors, and occupational/environmental exposures. Blood was collected (after fasting) in order to measure lipids, insulin, and potential susceptibility genes. Urine was collected to measure endogenous gonadotropins. Blood pressure, heart rate, weight, height, and waist-to-hip ratio were measured. Medical record data provide some minimal descriptive information on nonresponders. Tissue from surgical specimens will be analyzed for growth factors, hormonal conditions, and genetic characteristics of the fibroid. - fibroids, risk factors, prevalence, uterus, leiomyoma - Human Subjects & Human Subjects: Interview, Questionaires, or Surveys Only

工作摘要：与35-49岁的非黑人相比，黑人女性正在进行一项研究，以估计子宫肌瘤的患病率和危险因素（如标准的经腹和经阴道超声检查检测）。将研究去除肌瘤的女性的子宫组织，以鉴定与肌瘤发育相关的组织中的激素性蛋白质术，生长因子和遗传变化。已经从从35-49岁的医疗保健计划中随机识别的大约1500名妇女收集了数据，该计划服务于大约相等的黑人和白人。电话采访用于收集有关人口统计学因素，病史，饮食摄入量，生殖历史，生活方式因素以及职业/环境暴露的信息。收集血液（禁食后），以测量脂质，胰岛素和潜在的敏感性基因。收集尿液以测量内源性促性腺激素。测量血压，心率，体重，身高和腰围比。医疗记录数据提供了有关非反应者的一些最小描述性信息。将分析来自手术标本的组织，以分析肌瘤的生长因子，激素条件和遗传特征。 - 肌瘤，危险因素，患病率，子宫，平滑肌瘤 - 人类受试者和人类受试者：访谈，问题或调查