Prenatal Smoking and Patterns of Youth Problem Behavior

产前吸烟和青少年问题行为模式

• 批准号: 6704759
• 负责人: LAUREN S WAKSCHLAG
• 金额: $ 56.94万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6704759
• 关键词: adolescence (12-20); behavioral /social science research tag; child behavior; clinical research; conduct disorder; early experience; gender difference; human subject; interview; longitudinal human study; mother child interaction; nicotine; prenatal stress; psychometrics; questionnaires; smoking; substance abuse epidemiology; substance abuse related behavior; tobacco abuse

DESCRIPTION (provided by applicant): Prenatal exposure to cigarettes represents a potent risk factor for adverse behavioral outcomes including conduct problems and youth smoking. Existing research compellingly demonstrates that these increased behavioral risks are (a) robust to obvious confounding; (b) present across diverse contexts and; (c) consistent with evidence from basic science. Despite the robustness of these findings, considerable gaps remain in our understanding of mechanisms that link exposure to adverse behavioral outcomes. These gaps reflect fundamental methodologic limitations of studies to date and the need for theoretically-driven model development and testing that examines the role of characteristics of mothers who smoke during pregnancy in pathways from exposure to problem behavior in youth. The proposed study is designed to examine three questions fundamental to exploration of potential mechanisms and pathways that link prenatal cigarette exposure to later adverse behaviors: (1) What are the salient parameters of exposure that affect risk? (2) What is the specific nature of the problem behavior associated with prenatal exposure to cigarettes? and (3) How do the family contexts of prenatally exposed youth differ from those of non-exposed youth? The proposed research takes advantage of a unique opportunity to conduct a follow-up of the adolescent offspring of the Maternal-Infant Smoking Study of East Boston (MISSEB), a population-based cohort study with repeated, prospective biochemical and selfreported measurement of prenatal cigarette smoke exposure. Specific aims of the proposal are to: (1) examine the effects of variation in duration, timing and intensity of prenatal exposure on the development of youth conduct problems and smoking; (2) delineate specific types and patterns of problem behavioir" associated with prenatal exposure (including examination of sex differences) and; (3) characterize the family context of exposed youth and explore its potential contribution to pathways to problembehavior. 260 girls and boys (mean age=l 3) and their mothers will be studied prospectively over 4 years. The study will use existing MISSEB data on prenatal exposure and collect new data on problem behavior and family context from the MISSEB cohort at adolescence. Prenatal smoking patterns will be used as predictors of youth problem behavior. Multi-level modeling techniques will be used including survival analyses and longitudinal regression techniques. The family contexts of youth whose mothers smoked during pregnancy will be compared to those of youth whose mothers smoked but not during pregnancy and youth whose mothers are nonsmokers. The potential moderational role of family factors will be explored.

描述（由申请人提供）：产前接触香烟是不利行为结果的有效风险因素，包括行为问题和青年吸烟。现有的研究令人难以置信地表明，这些增加的行为风险是（a）强大而明显的混淆； （b）在各种环境中存在； （c）与基础科学的证据一致。尽管这些发现具有稳健性，但我们对将暴露与不良行为结果联系起来的机制的理解仍然存在很大的差距。这些差距反映了迄今为止研究的基本方法论局限性以及理论上驱动的模型开发和测试的需求，这些模型开发和测试检查了母亲在怀孕期间吸烟的特征的作用，从暴露于年轻人的问题行为。 拟议的研究旨在研究三个问题，这些问题是探索潜在的机制和途径，这些机制和途径将产前卷烟暴露与后来的不良行为联系起来：（1）影响风险的暴露的显着参数是​​什么？ （2）与产前暴露于香烟有关的问题行为的具体性质是什么？ （3）产前暴露的青年的家庭环境与非暴露年轻人的情况有何不同？拟议的研究利用了一个独特的机会，对东波士顿产妇吸烟研究的青少年后代进行了随访，这是一项基于人群的同类研究，并重复，前瞻性的生化和自我报告的测量来测量产前烟雾烟。 该提案的具体目的是：（1）检查持续时间，时间和强度的变化对青年行为的发展和吸烟的影响； （2）描述问题行为的特定类型和模式。在青春期，将使用青少年的烟雾在青年时期，将使用年轻人的行为。