2/2 Optimizing access, engagement and assessment to elucidate prenatal influences on neurodevelopment: The Brains Begin Before Birth(B4 ) Midwest Consortium

2/2 优化获取、参与和评估以阐明产前对神经发育的影响：大脑在出生前开始（B4）中西部联盟

• 批准号: 9900287
• 负责人: LAUREN S WAKSCHLAG
• 金额: $ 26.44万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2022-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9900287
• 关键词: Accounting; Address; Adverse effects; Age; Alcohol or Other Drugs use; Area; Behavior assessment; Behavioral; Bioethics; Bioethics Consultants; Biological Assay; Birth; Brain; Catalogs; Categories; Child; Child Development; Child Welfare; Childhood; Clinical; Cognitive; Collaborations; Communities; Data; Data Scientist; Data Set; Development; Discipline; Effectiveness; Electroencephalography; Emotional; Ensure; Epidemic; Epidemiology; Equilibrium; Ethics; Exposure to; Eye; Family; Feedback; Fertilization; Follow-Up Studies; Fostering; Functional Magnetic Resonance Imaging; Goals; Health; Human; Illinois; Image; Individual Differences; Infant; Institution; Interview; Leadership; Legal; Link; Longitudinal Studies; MRI Scans; Manuscripts; Measurement; Mental Health; Methodology; Methods; Midwestern United States; Missouri; Modality; Modeling; Modification; Multimodal Imaging; Neonatal Abstinence Syndrome; Neurosciences; Opioid; Outcome; Pathway interactions; Pattern; Perinatal; Phase; Phenotype; Policies; Population; Postpartum Period; Predictive Value; Pregnant Women; Protocols documentation; Public Health; Recommendation; Reporting; Reproducibility; Research; Research Design; Research Personnel; Risk; Science; Scientist; Site; Social Interaction; Structure; Surveys; Testing; Universities; Variant; Washington; Woman; addiction; adverse outcome; age group; base; behavioral economics; brain behavior; care coordination; cohort; community setting; design; drug of abuse; early childhood; early life exposure; falls; fetal; high risk; imaging modality; infant morbidity/mortality; innovation; intergenerational; longitudinal design; medical schools; middle childhood; mobile application; mobile computing; multidisciplinary; neurodevelopment; neuroimaging; novel; offspring; opioid abuse; opioid epidemic; opioid use; opioid use in pregnancy; peer; perinatal mental health; phase 2 designs; population health; portability; postnatal; prenatal; prenatal exposure; prenatal influence; psychosocial; racial and ethnic; recruit; regional difference; relating to nervous system; research study; resilience; retention rate; risk prediction model; service providers; social; study population; treatment center; willingness; Accounting; Address; Adverse effects; Age; Alcohol or Other Drugs use; Area; Behavior assessment; Behavioral; Bioethics; Bioethics Consultants; Biological Assay; Birth; Brain; Catalogs; Categories; Child; Child Development; Child Welfare; Childhood; Clinical; Cognitive; Collaborations; Communities; Data; Data Scientist; Data Set; Development; Discipline; Effectiveness; Electroencephalography; Emotional; Ensure; Epidemic; Epidemiology; Equilibrium; Ethics; Exposure to; Eye; Family; Feedback; Fertilization; Follow-Up Studies; Fostering; Functional Magnetic Resonance Imaging; Goals; Health; Human; Illinois; Image; Individual Differences; Infant; Institution; Interview; Leadership; Legal; Link; Longitudinal Studies; MRI Scans; Manuscripts; Measurement; Mental Health; Methodology; Methods; Midwestern United States; Missouri; Modality; Modeling; Modification; Multimodal Imaging; Neonatal Abstinence Syndrome; Neurosciences; Opioid; Outcome; Pathway interactions; Pattern; Perinatal; Phase; Phenotype; Policies; Population; Postpartum Period; Predictive Value; Pregnant Women; Protocols documentation; Public Health; Recommendation; Reporting; Reproducibility; Research; Research Design; Research Personnel; Risk; Science; Scientist; Site; Social Interaction; Structure; Surveys; Testing; Universities; Variant; Washington; Woman; addiction; adverse outcome; age group; base; behavioral economics; brain behavior; care coordination; cohort; community setting; design; drug of abuse; early childhood; early life exposure; falls; fetal; high risk; imaging modality; infant morbidity/mortality; innovation; intergenerational; longitudinal design; medical schools; middle childhood; mobile application; mobile computing; multidisciplinary; neurodevelopment; neuroimaging; novel; offspring; opioid abuse; opioid epidemic; opioid use; opioid use in pregnancy; peer; perinatal mental health; phase 2 designs; population health; portability; postnatal; prenatal; prenatal exposure; prenatal influence; psychosocial; racial and ethnic; recruit; regional difference; relating to nervous system; research study; resilience; retention rate; risk prediction model; service providers; social; study population; treatment center; willingness

PROJECT SUMMARY: The accelerating U.S. opioid crisis requires urgent scientific and public health action. Maternal perinatal use/abuse is particularly deleterious due to its reverberating intergenerational impact. Though prenatal exposure to opioids and other substances have adverse effects on neurodevelopment, advances in neuroimaging and developmentally- sensitive phenotypic measurement now enable characterization of typical and atypical brain- behavior pathways on an unprecedented scale. Mechanistic study that traces the multi-level determinants and patterns of risk and resilience from the prenatal period through childhood requires a large, national cohort that accounts for regional and racial/ethnic variation. We propose the Brains Begin Before Birth (B4) Midwest Consortium, a partnership of neuroscience, substance use, perinatal mental health and child welfare scientists at Washington University School of Medicine (WUSM) and neuroscience, bioethics, pediatric population health, maternal- fetal and addiction scientists at Northwestern University (NU). Along with scientific complementarity, a strength of this regional Consortium is its ability to leverage the contrasting approaches of Illinois (punitive) and Missouri (non-punitive) to prenatal opioid use, providing an exceptional platform for examining the impact of jurisdictional variations on science and practice. Together we provide a framework for addressing three major areas of challenge key to a high-quality, representative, national multi-site study: (1) Legal/Ethical: Led by NU bioethics and population health experts, we propose a mixed methods approach to delineating barriers and generating solutions to scientific engagement of opioid using pregnant women from varied jurisdictions; (2) Recruitment/Retention: Led by NU experts in behavioral economics approaches to research participation and WUSM experts in care coordination, child welfare and mobile technology, we use innovative methods to test differential effectiveness of messaging in recruitment materials using eye tracking, and employ novel apps and care coordination methods for retention enhancement; and (3) Imaging/Assessment Methods: Led by neuroscience and substance use experts at WUSM and an NU data scientist, we generate best practices recommendations for an informed protocol via: (i) pilot testing a comprehensive pre-/perinatal maternal substance/mental health protocol; (ii) obtaining feasibility data on MRI scans in neonatal abstinence syndrome, also testing other developmental imaging modalities (e.g., EEG, fNIRS), including in community settings; and (iii) applying state-of-the-art epidemiologic risk prediction methods to extant Consortium data to identify methods and timing of key assessments that provide added predictive value. All activities draw on extensive community stakeholder partnerships. Our central focus is the prenatal-early childhood period, with a framework designed to enable meaningful contributions to consortia including later childhood. Transdisciplinary integration spanning population health to neuroscience is essential to ensure that a large national effort delineating the impact of this pernicious epidemic and corollary risk on health and development of children and families can be fully realized.

项目摘要：加速的美国阿片类药物危机需要紧急科学和公众 健康行动。孕产妇围产期使用/滥用由于其回荡而特别有害 代际影响。尽管产前暴露于阿片类药物和其他物质有 对神经发育的不利影响，神经影像的进展和发展。 敏感的表型测量现在可以表征典型和非典型大脑的表征 行为途径在前所未有的规模上。追踪多层次的机械研究 从产前到童年的决定因素和风险和韧性的模式 需要一个大型的国家队列，以解决区域和种族/种族变化。我们 建议大脑在出生前开始（B4）中西部财团，神经科学的伙伴关系， 华盛顿大学的药物使用，围产期心理健康和儿童福利科学家 医学院（WUSM）和神经科学，生物伦理学，儿科人口健康，母亲 - 西北大学（NU）的胎儿和成瘾科学家。以及科学 互补性，该区域财团的优势是其利用对比的能力 伊利诺伊州（惩罚性）和密苏里州（非态）的方法 卓越的平台来研究管辖权变化对科学和 实践。我们共同提供了一个框架，以解决挑战的三个主要领域的关键 高质量，代表，国家多站点研究：（1）法律/道德：NU BioEthics领导 和人口健康专家，我们提出了一种混合方法来描述障碍 并使用来自不同的孕妇生成阿片类药物科学参与的解决方案 管辖权； （2）招聘/保留：由NU行为经济学专家领导 研究参与的方法和WUSM护理协调，儿童福利和 移动技术，我们使用创新方法来测试消息传递的差异有效性 使用眼动招聘材料，并采用新颖的应用程序和护理协调方法 保留增强； （3）成像/评估方法：由神经科学和 WUSM的药物使用专家和NU数据科学家，我们创造了最佳实践 通过：（i）试点测试全面的预/围产期的试点测试的知情协议的建议 母体物质/心理健康方案； （ii）获取有关MRI扫描的可行性数据 新生儿禁欲综合征，还测试其他发育成像方式（例如，脑电图， fnirs），包括在社区环境中； （iii）应用最先进的流行病学风险 现有财团数据的预测方法以识别密钥的方法和时间安排 提供增加预测价值的评估。所有活动都借鉴了广泛的社区 利益相关者合作伙伴关系。我们的核心重点是产前和童年时期， 框架旨在为包括后期的童年（包括后期的童年）做出有意义的贡献。 跨学科整合跨越人群健康到神经科学对于确保 一项巨大的国家努力描述了这种有害流行病和推论风险的影响 关于儿童和家庭的健康和发展，可以完全实现。