NEUROPSYCHIATRIC IMPAIRMENT IN ADOLESCENT INHALANT USERS

青少年吸入剂使用者的神经精神损伤

• 批准号: 6584578
• 负责人: MATTHEW O HOWARD
• 金额: $ 7.65万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-25 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6584578
• 关键词: adolescence (12-20); behavior disorders; behavior test; behavioral /social science research tag; clinical research; cognition disorders; correctional institutions; criminal behavior; human subject; inhalation drug abuse; longitudinal human study; mental disorders; neurotoxicology; social behavior disorders; substance abuse epidemiology; substance abuse related behavior; violence

DESCRIPTION (provided by applicant): Few studies have examined the prevalence of DSM-IV Inhalant Use Disorders or the relationship of inhalant intoxication to adverse biopsychosocial outcomes, high-risk behavior, and neuropsychiatric impairments among youth at high risk for the occurrence of inhalant-related problems. Specific aims of the proposed RO3 are to: 1) Describe the prevalence of DSM-IV Inhalant Use Disorders and prior episodes of interpersonal violence, criminal acts, high-risk behaviors and other adverse biopsychosocial outcomes associated with inhalant intoxication in a state population of incarcerated youth, 2) Describe the prevalence of nonprescription asthma inhaler abuse, reasons for abuse, characteristics of incarcerated youth who abuse inhalers, and adverse consequences of inhaler intoxication, and 3) Describe the nature and severity of cognitive and psychiatric impairments among heavy adolescent inhalant abusers relative to matched non-users and the persistence of these impairments over six months. All youth (N equals approximately 716) incarcerated in Missouri Division of Youth Services (DYS) institutions will be screened for lifetime inhalant use. Inhalant users will complete assessments of legal, social, psychological, and medical consequences associated with episodes of inhalant intoxication and measures of attitudes toward inhalants, contexts/modes of use, and DSM-IV Inhalant Abuse/Dependence. The proposed research will also yield important new findings describing the prevalence and characteristics of nonprescription asthma inhaler abuse. Further, the proposed RO3 presents a unique opportunity to study the nature and reversibility of specific neuropsychological impairments/psychiatric syndromes in youth at high risk for the development of inhalant related neurotoxicity and associated functional impairments. The project incorporates a case-control study comparing heavy recent adolescent inhalant users to a matched sample of inhalant-negative youth across measures of cognitive performance and psychiatric symptoms. Case-control subjects will complete assessment batteries shortly following their incarceration and 6-months later. Study findings will yield key information about the prevalence of DSM-IV Inhalant Use Disorders among youth in correctional settings and new data regarding adverse legal, social, and health outcomes and persistent neuropsychiatric impairments associated with inhalant intoxication. Study findings will contribute to more effective prevention and treatment efforts with youth at high risk for inhalant-related problems.

描述（由申请人提供）：很少有研究调查了 DSM-IV 吸入性使用障碍的患病率或吸入性中毒与不良生物心理社会结果、高危行为和吸入性吸入性高危青少年中的神经精神损伤之间的关系。相关问题。 拟议 RO3 的具体目标是： 1) 描述州监禁人口中 DSM-IV 吸入剂使用障碍的患病率以及先前发生的人际暴力、犯罪行为、高风险行为以及与吸入中毒相关的其他不良生物心理社会结果青少年，2) 描述非处方哮喘吸入器滥用的流行情况、滥用原因、滥用吸入器的被监禁青少年的特征以及吸入器中毒的不良后果， 3) 描述相对于匹配的非使用者而言，重度青少年吸入性滥用者认知和精神障碍的性质和严重程度，以及这些障碍在六个月内的持续情况。密苏里州青少年服务部 (DYS) 机构中监禁的所有青少年（N 约等于 716 名）都将接受终生吸入使用情况筛查。吸入剂使用者将完成与吸入中毒事件相关的法律、社会、心理和医疗后果的评估，以及对吸入剂的态度、使用环境/模式和 DSM-IV 吸入剂滥用/依赖的测量。拟议的研究还将产生重要的新发现，描述非处方哮喘吸入器滥用的流行率和特征。此外，拟议的 RO3 提供了一个独特的机会来研究具有吸入相关神经毒性和相关功能障碍发展高风险的青少年特定神经心理障碍/精神综合征的性质和可逆性。该项目纳入了一项病例对照研究，通过认知表现和精神症状的测量，对近期大量吸入吸入剂的青少年与吸入剂阴性青少年的匹配样本进行比较。病例对照受试者将在入狱后不久和六个月后完成一系列评估。研究结果将提供有关惩教环境中青少年中 DSM-IV 吸入使用障碍患病率的关键信息，以及有关不良法律、社会和健康结果以及与吸入中毒相关的持续神经精神损伤的新数据。 研究结果将有助于对吸入相关问题高危青少年进行更有效的预防和治疗。