Natural History, Comorbid Mental Disorders, and Consequences of Inhalant Abuse

自然史、共病精神障碍以及吸入性滥用的后果

• 批准号: 7497094
• 负责人: MATTHEW O HOWARD
• 金额: $ 17.02万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-15 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7497094
• 关键词: Accident and Emergency department; Accounting; Acculturation; Adult; Age; Alcohol or Other Drugs use; Alcohols; Area; Case Study; Case-Control Studies; Chronic; Clinical; Clinical Trials; Comorbidity; Complex; Condition; Control Groups; DSM-IV; Data; Data Set; Development; Diagnosis; Diagnostic; Disease; Disease remission; Drug Use Disorder; Drug abuse; Drug usage; Drug user; Ensure; Environment; Epidemiologist; Exposure to; Future; Gasoline; Gender; General Population; Glues; Health; Healthcare; Hispanics; Hospitalization; Household; Immigration; Individual; Inhalant dose form; Intervention; Investigation; Legal Status; Life; Literature; Malignant - descriptor; Medical; Mental Health; Mental disorders; National Institute of Drug Abuse; Natural History; Numbers; Outcome; Personality; Personality Disorders; Population; Prevalence; Prevention; Productivity; Public Health; Publishing; Rate; Recording of previous events; Reporting; Research; Research Personnel; Resources; Respondent; Risk; Risk Factors; Role; Sampling; Structure; Substance Use Disorder; Surveys; Taxonomy; Work; base; comparative; cost; design; drug abuser; experience; functional disability; functional outcomes; health care service utilization; inhalation drug abuse; knowledge base; member; neglect; programs; response; social; treatment trial

DESCRIPTION (provided by investigator): Inhalant use is among the most pernicious and poorly studied forms of drug abuse. Little is known about the natural history, long-term health and social consequences, functional impairments, psychiatric comorbidities, and treatment experiences of inhalant users in the general population. The proposed study will draw upon data recently collected in association with the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a 3-wave longitudinal investigation of a nationally representative sample (N= 43,093) of adults living in the U.S. NESARC is one of the largest psychiatric comorbidity studies ever conducted and the first to assess DSM-IV Axis II Personality Disorders, yet no inhalant studies using NESARC data have been published. Wave 1 data are available for use, response rates were high, and the dataset includes 106 variables specific to inhalant use and DSM-IV Inhalant Use Disorders. The proposed research will constitute the most comprehensive set of population-based investigations of inhalant use heretofore undertaken and will greatly increase the knowledge base upon which new inhalant prevention and clinical interventions can be developed by: 1) identifying risk factors for inhalant use and Inhalant Use Disorders and developing an empirically-based taxonomy identifying subtypes of inhalant users, 2) describing the natural history of Inhalant Use Disorders in the general population, including factors predicting onset, escalation, persistence, and stable remission of inhalant use and Inhalant Use Disorders, 3) estimating the prevalence of psychiatric disorders in individuals with lifetime inhalant use/Inhalant Use Disorders and the prevalence of inhalant use/Inhalant Use Disorders among individuals with different psychiatric disorders, and conducting case- control studies evaluating the extent to which inhalant users are' at elevated risk for psychiatric disorders compared to other drug abusers and respondents without drug use disorders, 4) evaluating the independent contribution of inhalant use and Inhalant Use Disorders to the development of serious medical conditions, adverse social consequences, and health and mental health-related functional impairments, and 5) describing the substance-related and general medical health care treatment experiences of inhalant users including types of treatment sought, utilization rates, perceived barriers to treatment, and differences between inhalant users and other drug users with regard to these factors.

描述（由研究者提供）：吸入剂是最有害且研究较少的药物滥用形式之一。对于一般人群中吸入剂使用者的自然史、长期健康和社会后果、功能障碍、精神合并症和治疗经验知之甚少。拟议的研究将利用最近与国家酒精及相关疾病流行病学调查 (NESARC) 相关的数据，该调查对居住在美国的成年人的全国代表性样本 (N= 43,093) 进行了三波纵向调查。NESARC 是其中之一有史以来最大规模的精神科合并症研究，也是第一个评估 DSM-IV Axis II 人格障碍的研究，但尚未使用 NESARC 数据进行吸入性研究发表。第 1 波数据可供使用，响应率很高，数据集包括 106 个特定于吸入剂使用和 DSM-IV 吸入剂使用障碍的变量。拟议的研究将构成迄今进行的最全面的基于人群的吸入剂使用调查，并将大大增加开发新的吸入剂预防和临床干预措施的知识基础：1）确定吸入剂使用的风险因素和吸入剂使用疾病并开发基于经验的分类法来识别吸入剂使用者的亚型，2) 描述普通人群中吸入剂使用障碍的自然史，包括预测发病的因素，吸入使用和吸入使用障碍的升级、持续和稳定缓解，3) 估计终生吸入使用/吸入使用障碍个体中精神障碍的患病率以及患有不同精神障碍的个体中吸入使用/吸入使用障碍的患病率，进行病例对照研究，评估与其他药物滥用者相比，吸入剂使用者患精神疾病的风险升高的程度，没有吸毒障碍的受访者，4) 评估吸入剂使用和吸入剂使用障碍对严重医疗状况、不良社会后果以及健康和心理健康相关功能障碍的独立影响，以及 5) 描述与物质相关的和吸入剂使用者的一般医疗保健治疗经历，包括寻求的治疗类型、使用率、感知的治疗障碍以及吸入剂使用者与其他吸毒者在这些因素方面的差异。