Ventricular Size and Value Calcification Measures by CT

通过 CT 测量心室大小和钙化值

• 批准号: 6784701
• 负责人: MATTHEW J BUDOFF
• 金额: $ 23.65万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6784701
• 关键词: atherosclerosis; bioimaging /biomedical imaging; calcification; cardiovascular disorder epidemiology; cardiovascular disorder risk; clinical research; computed axial tomography; heart dimension /size; heart imaging /visualization /scanning; human data; human middle age (35-64); human old age (65+); noninvasive diagnosis

DESCRIPTION (provided by applicant): This study is ancillary study proposal for the MultiEthnic Study of Atherosclerosis (MESA) Trial, a prospective investigation of the etiology and natural history of atherosclerosis and the ability of non-invasive tools to measure atherosclerotic burden and identify high, risk individuals in a large, population-based cohort. The development of computed tomography (CT) to evaluate coronary calcification (CC) now provides a tool to directly measure coronary atherosclerosis non-invasively. The information obtained by CT however provides more information than CC alone. CT has the ability to measure and quantitate aortic valve calcification (AVC), mitral annular calcification (MAC), aortic wall calcification and left ventricular size (LVS). The longitudinal nature of this study will allow epidemiologic associations to be established for a multitude of risk factors and these measures, establishing both the time sequence for each measure and consistency of the association in a variety of populations (ethnicity, gender, geographical location and age). Magnetic resonance imaging of the heart will also be obtained as part of the MESA trial, and comparisons of LV size by CT to magnetic resonance measures will also be performed. We propose to utilize scans already obtained as part of the calcium scanning (at baseline and 3.5 year follow-up), and make these four measures on baseline and follow-up scans obtained. The additive value of these simple measures to CC score could possibly provide clinicians with even more power to identify and stratify the high-risk cardiac patient with both findings. This study will also establish the prevalence, in a population based study, of all both AVC and MAC, using a technique highly sensitive to see these abnormalities. It has been postulated that a 'total atherosclerotic burden' could be obtained by adding CAC to thoracic aortic calcification, and this total atherosclerosis score (with or without MAC and AVC) might better predict cardiovascular events than CAC alone. Similarly, this cohort of 6500 patients with repeat scans can be assessed for factors that enhance or inhibit progression of LVS, mitral annular, aortic valve or wall calcification, lending insight into therapies that have efficacy against progression of aortic sclerosis or left ventricular enlargement.

描述（由申请人提供）：这项研究是针对动脉粥样硬化试验（MESA）试验多种族研究的辅助研究建议，对动脉粥样硬化的病因和自然历史的前瞻性研究以及非侵入性工具测量动脉粥样硬化造成的工具的能力，以测量动脉粥样硬化负担和基于人群的大型人群中的高风险个人。现在，评估冠状动脉钙化（CC）的计算机断层扫描（CT）的开发提供了一种工具，可以直接测量冠状动脉粥样硬化。但是，CT获得的信息比单独使用CC提供了更多的信息。 CT具有测量和定量主动脉瓣钙化（AVC），二尖瓣环钙化（MAC），主动脉壁钙化和左心室大小（LVS）的能力。这项研究的纵向性质将允许为多种危险因素和这些措施建立流行病学关联，从而确定各种人群（种族，性别，地理位置和年龄）的每种度量的时间顺序和关联的时间顺序。还将作为MESA试验的一部分获得心脏的磁共振成像，并且还将进行CT大小与磁共振测量的LV大小的比较。我们建议利用已经作为钙扫描的一部分（基线和3。5年随访）进行的扫描，并在基线和随访扫描上进行这四个措施。这些简单措施对CC评分的添加价值可能会为临床医生提供更大的能力，以识别和对两种发现的高危心脏患者进行分层。这项研究还将使用一种高度敏感的技术观察到这些异常的技术，在一项基于人群的研究中，在所有AVC和MAC的基于人群的研究中确定患病率。据推测，可以通过将CAC添加到胸部主动脉钙化中来获得“全动脉粥样硬化负担”，而这种总动脉粥样硬化评分（有或没有MAC和AVC）可以更好地预测心血管事件，而不是单独预测心血管事件。同样，可以评估6500例重复扫描患者的队列，以增强或抑制LVS，二尖瓣环形，主动脉瓣或壁钙化的进展，从而介绍对抗主动脉硬化或左心室扩大有效性的治疗方法的见解。