Epidemiology of Breast Arterial Calcification

乳腺动脉钙化的流行病学

• 批准号: 6805469
• 负责人: DANA H WHALEY
• 金额: $ 12.89万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-17 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6805469
• 关键词: atherosclerosis; bioimaging /biomedical imaging; calcification; cardiovascular disorder diagnosis; cardiovascular disorder risk; cardiovascular imaging /visualization; clinical research; comorbidity; coronary disorder; female; human subject; mammography; myocardial infarction; patient oriented research; sudden cardiac death; tomography; women' s health

DESCRIPTION (provided by applicant): The study hypothesis is that breast arterial calcification (BAC) seen on mammograms can identify women with an increased risk of coronary artery disease (CAD). Annual mammograms are now routinely obtained on nearly 70% of women over forty years of age. The nearly 40 million examinations performed every year could be used to evaluate for BAC without any additional cost or change in current mammographic techniques. Identification of women with BAC has potential to substantially decrease the rate of heart attack and sudden death due to CAD in asymptomatic women. Before BAC can be used in a clinical setting, the age-specific prevalence of BAC needs to be fully defined using state of the art mammographic techniques. BAC then needs to be compared with well understood CAD risk factors and measures of coronary atherosclerosis. While this could be accomplished in a prospective study, we can attain the same goals using data already acquired in the Epidemiology of Coronary Calcification (ECAC) Study. Using this preexisting database fulfills one of the requirements for this NHLBI R21 Grant. Coronary artery calcification (CAC) is detected non-invasively on electron beam computed tomographic (EBCT) exams. CAC quantity correlates well with atherosclerotic plaque area. This population-based study has been instrumental in establishing the distribution of presence and quantity of CAC as well as the predictors of CAC. The database includes clinical and laboratory assessments of CAD risk factors, results of EBCTs, and findings on physical examinations. It will ultimately include information on adverse clinical events. There are 612 female participants who had one or more mammograms during the 12-year history of that study. Many women had 10 or more mammograms. The proposal is to evaluate all of these mammograms for BAC and compare the findings with information already in the database. The combination of newly acquired data from mammograms with the existing data allows this to be a very comprehensive study and still be completed in the two-year time period and with the funding constraints of this R21 grant. The findings can then be used to help design a future study to prospectively evaluate the impact of instituting preventive and early therapeutic measures for CAD in asymptomatic women with the appropriate features of BAC on mammography.

描述（由申请人提供）：研究假设是在乳房X线照片上看到的乳腺动脉钙化（BAC）可以鉴定患有冠状动脉疾病风险增加（CAD）的女性。现在，通常将近70％的40岁妇女获得年度乳房X线照片。每年进行的近4000万次考试可用于评估BAC，而无需任何额外的成本或当前乳房X线学技术的变化。患有BAC的女性的鉴定有可能大大降低无症状女性CAD引起的心脏病发作率和猝死。在BAC可以在临床环境中使用之前，需要使用最先进的乳房X线X线X线X线X线X线X线X线X线X线X线X线X线X线X线X线X线X线X线X线X型。然后，需要将BAC与众所周知的CAD危险因素和冠状动脉粥样硬化的措施进行比较。尽管这可以在一项前瞻性研究中实现，但我们可以使用在冠状动脉钙化（ECAC）研究中已经获得的数据实现相同的目标。使用此先前存在的数据库满足此NHLBI R21赠款的要求之一。冠状动脉钙化（CAC）在电子束计算机断层扫描（EBCT）检查中无创检测到。 CAC数量与动脉粥样硬化斑块区域密切相关。这项基于人群的研究对确定CAC的存在和数量的分布以及CAC的预测因素发挥了作用。该数据库包括对CAD危险因素，EBCT结果的临床和实验室评估，以及有关身体检查的结果。它最终将包括有关不良临床事件的信息。在该研究的12年历史中，有612名女性参与者有一个或多个乳房X线照片。许多女性有10张或更多的乳房X线照片。该建议是评估所有这些乳房X线照片的BAC，并将发现与数据库中的信息进行比较。从乳房X线照片中获得新获取的数据以及现有数据的结合，这将是一项非常全面的研究，并且在两年的时间段内仍可以完成此R21赠款的资金限制。然后，这些发现可用于帮助设计未来的研究，以预先评估在无症状女性中对CAD采取预防和早期治疗方法的影响，具有BAC X线摄影的适当特征。