Epidemiology of Carotid IMT Progression in MESA

MESA 颈动脉 IMT 进展的流行病学

• 批准号: 6618580
• 负责人: JOSEPH F POLAK
• 金额: $ 60.21万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-15 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6618580
• 关键词: angiocardioultrasonography; atherosclerosis; bioimaging /biomedical imaging; calcification; cardiovascular disorder diagnosis; cardiovascular disorder epidemiology; carotid artery; clinical research; human subject

DESCRIPTION (provided by applicant): This application seeks to determine the factors associated with progression of sub-clinical atherosclerosis and to evaluate the associations between the progression of sub-clinical atherosclerosis and the development of clinically manifest atherosclerosis. Changes in sub-clinical atherosclerotic disease are measured noninvasively using high resolution B-mode ultrasound and presented as changes in wall thickness (in millimeters) of the carotid artery (carotid IMT). Carotid IMT is well recognized as a measure of atherosclerotic burden. Progression of disease is hypothesized to precede the development of clinical events. The current application is also designed to be able to compare progression of carotid IMT with changes in coronary calcium score, a measure of coronary artery disease. Development of clinical atherosclerosis is evaluated by onset of clinical events (myocardial infarction, stroke, angina.) in an established cohort with a broad age-distribution and a multi-ethnic composition (MESA: Multi-Ethnic Study of Atherosclerosis). As compared to previous published works on the topic, this application offers the opportunity of measuring atherosclerosis across a broad age distribution and in a multi-ethnic cohort using state-of-the-art technologies.

描述（由申请人提供）：本申请旨在确定与亚临床动脉粥样硬化进展相关的因素，并评估亚临床动脉粥样硬化进展与临床明显动脉粥样硬化发展之间的关联。亚临床动脉粥样硬化疾病的变化可使用高分辨率 B 型超声进行无创测量，并以颈动脉壁厚度（以毫米为单位）的变化（颈动脉 IMT）来呈现。颈动脉 IMT 被广泛认为是衡量动脉粥样硬化负担的指标。假设疾病的进展先于临床事件的发生。当前的应用程序还旨在能够将颈动脉 IMT 的进展与冠状动脉钙评分（冠状动脉疾病的衡量标准）的变化进行比较。临床动脉粥样硬化的发展是通过在具有广泛年龄分布和多种族组成的既定队列中临床事件（心肌梗塞、中风、心绞痛）的发作来评估的（MESA：动脉粥样硬化的多种族研究）。与之前发表的有关该主题的作品相比，该应用程序提供了使用最先进的技术测量广泛年龄分布和多种族群体中动脉粥样硬化的机会。