Ventricular Size and Valve Calcification Measures by CT

CT 测量心室大小和瓣膜钙化

• 批准号: 7649993
• 负责人: MATTHEW J BUDOFF
• 金额: $ 53.15万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7649993
• 关键词: Address; Adipose tissue; Adult; Ankle; Atherosclerosis; Blood Pressure; Blood Vessels; C-reactive protein; Calcium; Cardiac; Cardiovascular system; Chest; Chronic; Cirrhosis; Clinical; Coronary; Coronary artery; Data; Deposition; Detection; Development; Diabetes Mellitus; Diabetic Angiopathies; Disease; Epidemiology; Ethnic Origin; Ethnic group; Evaluation; Event; Fatty Liver; Fatty acid glycerol esters; Functional disorder; Funding; Gender; Genotype; High Prevalence; Hormones; Hypertriglyceridemia; Hyperuricemia; Image; Incidence; Individual; Inflammation; Inflammatory; Insulin Resistance; Investigation; Knowledge; Lead; Link; Liver; Liver Failure; Liver diseases; Logistic Regressions; Magnetic Resonance Imaging; Measurable; Measurement; Measures; Medial; Metabolic syndrome; Modeling; Non obese; Obesity; Outcome; Participant; Pathology; Phenotype; Population; Prevalence; Race; Research Design; Resources; Risk; Risk Factors; Severities; Spleen; Testing; Therapeutic; Thick; Tissues; Ultrasonography; United States; Vascular Diseases; Ventricular; Woman; X-Ray Computed Tomography; aortic valve; attenuation; base; calcification; cardiovascular risk factor; cohort; coronary artery calcification; disorder risk; genetic association; genetic epidemiology; glucose metabolism; hypercholesterolemia; improved; indexing; inflammatory marker; insight; liver imaging; liver visualization; men; non-alcoholic fatty liver; nonalcoholic steatohepatitis; novel diagnostics; population based; prospective; time use; trait

This proposal is coordinated with the Multi-Ethnic Study of Atherosclerosis (MESA), a large prospective epidemioloigic study investigating multiple subclinical CVD measures and CVD risk factors. Subclinical measures in MESA include coronary calcium, carotid ultrasound, cardiac magnetic resonance imaging, and the ankle/brachial blood pressure index. The extensive CVD risk factor assessement includes both traditional risk factors and newer measures such as inflammatory and endothelial function measures. The primary long-term objective of this proposal is to determine the epidemiology and genetics of non-alcoholic fatty liver (NAFLD). Increasing data suggests a causal link between NAFLD and metabolic syndrome/diabetes, subclinical atherosclerosis and cardiovascular outcomes. CT has been well validated to evaluate liver fat, by comparing the liver attenuation and spleen. The cardiac studies performed in MESA allow for visualization of the liver and spleen in up to 93% of all studies, and should provide ample power to allow assessment of this disease, as well as temporal changes over time, using the non-enhanced cardiac CT scans already obtained, with no participant burden. This portion of the project has three primary specific aims: 1) Determine the prevalence and clinical correlates of fatty liver in the Multi-Ethnic Study of Atherosclerosis, including diabetes, insulin resistance and inflammatory markers; 2) Determine the cross-sectional and longitudinal associations of fatty liver with vascular and valvular calcification and subclinical atherosclerosis (including coronary calcium and carotid intimalmedia thickness); 3) Determine the association of fatty liver with incident cardiovascular events. This current proposed study should allow the first large assessment of the relationship of NAFLD, as measured by CT, to subclinical atherosclerosis (ankle brachial index, coronary artery calcium, carotid intimal media thickness, inflammation, aortic atherosclerosis-both thoracic and aortic) and subsequent events in a multi-ethnic population. The MESA study is an exceptionally well phenotyped and genotyped multiethnic cohort – and truly among the most valuable epidemiological resources in the world. The application proposes NAFLD – examining the cross-sectional relations with risk factors, subclinical disease, inflammatory markers and the relation to incident events. If successful the new information related to the pathophysiology, as well as relationships to cardiovascular risk factors and subclinical atherosclerosis, may form the basis for the development of new diagnostic or therapeutic strategies that improve detection or reduce the burden of NAFLD and associated CV disease.

该建议与动脉粥样硬化的多种族研究（MESA）协调，该研究研究了一项大量的前瞻性流行运动研究，研究了多个亚临床CVD测量和CVD风险因素。 MESA中的亚临床测量包括冠状动脉钙，颈动脉超声，心脏磁共振成像和脚踝/臂血压指数。广泛的CVD风险因素评估包括传统的危险因素和较新的测量，例如炎症和内皮功能测量。该提案的主要目标是确定非酒精性脂肪肝（NAFLD）的流行病学和遗传学。增加数据表明NAFLD与代谢综合征/糖尿病，亚临床动脉粥样硬化和心血管结局之间存在因果关系。通过比较肝脏衰减和脾脏，已对CT进行了很好的验证以评估肝脏脂肪。在MESA中进行的心脏研究允许可视化肝脏并在所有研究中最多可视化93％，并应提供足够的能力来评估该疾病，并使用已经获得的非增强心脏CT扫描随时间变化，而无需参与。该项目的这一部分具有三个主要的特定目的：1）在动脉粥样硬化的多种族研究中确定脂肪肝的患病率和临床相关性，包括糖尿病，胰岛素抵抗和炎症标志物； 2）确定脂肪肝的横截面和纵向相关性，其血管和瓣膜计算以及亚临床动脉粥样硬化（包括冠状动脉钙和颈动脉内膜厚度）； 3）确定脂肪肝与入射心血管事件的关联。当前的建议研究应允许通过CT测量的NAFLD与亚临床动脉粥样硬化（踝臂指数，冠状动脉钙，颈动脉内膜培养基厚度，炎症，炎症，主动脉粥样硬化性触动性 - 胸膜和主动脉症）以及多个事件中的事件中的事件进行首次大规模评估。 MESA研究是一项非常良好的表型和基因型的多民族队列，并且确实是世界上最有价值的流行病学资源之一。申请提案NAFLD - 检查与危险因素，亚临床疾病，炎症标志物以及与事件事件的关系的横断面关系。如果成功的新信息与病理生理学有关，以及与心血管危险因素和亚临床动脉粥样硬化的关系，可能是发展新的诊断或治疗策略的基础，从而改善了NAFLD和相关CV疾病的燃烧或减少燃烧。