Ventricular Size and Valve Calcification Measures by CT

CT 测量心室大小和瓣膜钙化

• 批准号: 7649993
• 负责人: MATTHEW J BUDOFF
• 金额: $ 53.15万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7649993
• 关键词: Address; Adipose tissue; Adult; Ankle; Atherosclerosis; Blood Pressure; Blood Vessels; C-reactive protein; Calcium; Cardiac; Cardiovascular system; Chest; Chronic; Cirrhosis; Clinical; Coronary; Coronary artery; Data; Deposition; Detection; Development; Diabetes Mellitus; Diabetic Angiopathies; Disease; Epidemiology; Ethnic Origin; Ethnic group; Evaluation; Event; Fatty Liver; Fatty acid glycerol esters; Functional disorder; Funding; Gender; Genotype; High Prevalence; Hormones; Hypertriglyceridemia; Hyperuricemia; Image; Incidence; Individual; Inflammation; Inflammatory; Insulin Resistance; Investigation; Knowledge; Lead; Link; Liver; Liver Failure; Liver diseases; Logistic Regressions; Magnetic Resonance Imaging; Measurable; Measurement; Measures; Medial; Metabolic syndrome; Modeling; Non obese; Obesity; Outcome; Participant; Pathology; Phenotype; Population; Prevalence; Race; Research Design; Resources; Risk; Risk Factors; Severities; Spleen; Testing; Therapeutic; Thick; Tissues; Ultrasonography; United States; Vascular Diseases; Ventricular; Woman; X-Ray Computed Tomography; aortic valve; attenuation; base; calcification; cardiovascular risk factor; cohort; coronary artery calcification; disorder risk; genetic association; genetic epidemiology; glucose metabolism; hypercholesterolemia; improved; indexing; inflammatory marker; insight; liver imaging; liver visualization; men; non-alcoholic fatty liver; nonalcoholic steatohepatitis; novel diagnostics; population based; prospective; time use; trait

This proposal is coordinated with the Multi-Ethnic Study of Atherosclerosis (MESA), a large prospective epidemioloigic study investigating multiple subclinical CVD measures and CVD risk factors. Subclinical measures in MESA include coronary calcium, carotid ultrasound, cardiac magnetic resonance imaging, and the ankle/brachial blood pressure index. The extensive CVD risk factor assessement includes both traditional risk factors and newer measures such as inflammatory and endothelial function measures. The primary long-term objective of this proposal is to determine the epidemiology and genetics of non-alcoholic fatty liver (NAFLD). Increasing data suggests a causal link between NAFLD and metabolic syndrome/diabetes, subclinical atherosclerosis and cardiovascular outcomes. CT has been well validated to evaluate liver fat, by comparing the liver attenuation and spleen. The cardiac studies performed in MESA allow for visualization of the liver and spleen in up to 93% of all studies, and should provide ample power to allow assessment of this disease, as well as temporal changes over time, using the non-enhanced cardiac CT scans already obtained, with no participant burden. This portion of the project has three primary specific aims: 1) Determine the prevalence and clinical correlates of fatty liver in the Multi-Ethnic Study of Atherosclerosis, including diabetes, insulin resistance and inflammatory markers; 2) Determine the cross-sectional and longitudinal associations of fatty liver with vascular and valvular calcification and subclinical atherosclerosis (including coronary calcium and carotid intimalmedia thickness); 3) Determine the association of fatty liver with incident cardiovascular events. This current proposed study should allow the first large assessment of the relationship of NAFLD, as measured by CT, to subclinical atherosclerosis (ankle brachial index, coronary artery calcium, carotid intimal media thickness, inflammation, aortic atherosclerosis-both thoracic and aortic) and subsequent events in a multi-ethnic population. The MESA study is an exceptionally well phenotyped and genotyped multiethnic cohort – and truly among the most valuable epidemiological resources in the world. The application proposes NAFLD – examining the cross-sectional relations with risk factors, subclinical disease, inflammatory markers and the relation to incident events. If successful the new information related to the pathophysiology, as well as relationships to cardiovascular risk factors and subclinical atherosclerosis, may form the basis for the development of new diagnostic or therapeutic strategies that improve detection or reduce the burden of NAFLD and associated CV disease.

该提案与动脉粥样硬化多种族研究 (MESA) 相协调，这是一项大型前瞻性流行病学研究，调查多种亚临床 CVD 测量值和 CVD 危险因素，MESA 中的亚临床测量值包括冠状动脉钙化、颈动脉超声、心脏磁共振成像和踝关节检查。 /肱动脉血压指数。广泛的 CVD 危险因素评估包括传统的危险因素和炎症和内皮功能测量等新措施。该提案旨在确定非酒精性脂肪肝 (NAFLD) 的流行病学和遗传学，越来越多的数据表明，NAFLD 与代谢综合征/糖尿病、亚临床动脉粥样硬化和心血管结果之间的因果关系已得到充分验证，可以通过以下方式评估肝脏脂肪。比较肝脏衰减和脾脏 在 MESA 中进行的心脏研究允许在高达 93% 的研究中实现肝脏和脾脏的可视化，并且应该提供使用已获得的非增强心脏 CT 扫描，有足够的能力来评估这种疾病以及随时间的时间变化，而无需参与者承担该项目的这一部分有三个主要具体目标：1）确定患病率和患病率。动脉粥样硬化多种族研究中脂肪肝的临床相关性，包括糖尿病、胰岛素抵抗和炎症标志物 2) 确定脂肪肝与血管和瓣膜钙化的横向和纵向关联；亚临床动脉粥样硬化（包括冠状动脉钙和颈动脉内膜厚度）；3）确定脂肪肝与心血管事件的关联，目前提出的这项研究应该能够首次大规模评估通过 CT 测量的 NAFLD 与亚临床动脉粥样硬化的关系。踝臂指数、冠状动脉钙、颈动脉内膜中层厚度、炎症、主动脉粥样硬化（胸主动脉和主动脉）以及后续事件MESA 研究是一个非常好的表型和基因型多种族队列——并且确实是世界上最有价值的流行病学资源之一——该应用程序提出了 NAFLD——检查与危险因素、亚临床疾病、如果成功，与病理生理学以及与心血管危险因素和亚临床动脉粥样硬化的关系相关的新信息可能会成为开发新诊断的基础。或改善 NAFLD 及相关心血管疾病的检测或减轻其负担的治疗策略。