The Genetic Structure of Natural Populations of Past and

过去和现在自然种群的遗传结构

• 批准号: 6558899
• 负责人: STEPHEN J O'BRIEN
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6558899
• 关键词: AIDS; animal genetic material tag; animal population genetics; animal population study; biochemical evolution; cats; disease /disorder model; evolution; feline immunodeficiency virus; genetic mapping; genetic markers; genetic polymorphism; immunogenetics; mitochondrial DNA; nucleic acid repetitive sequence; species difference

Novel nuclear and mitochondrial genetic markers have been developed and described in various species improving our ability to assess patterns of genetic variation within and among species and to reconstruct historical evolutionary events. The results have indicated abundant molecular genetic diversity among South American species, leopards, bobcats and limited variation in North American pumas, tigers, Iberian lynx, and previously documented bottlenecked cheetahs, pumas and lions. Concordant phylogenetic and phylogeographic studies of feline immunodeficiency virus transmission among free-ranging cat populations allows a glimpse of the process of emerging infections in species well suited for discovery of these events. Insight gained from these studies reveals evolved mechanisms for immune and natural defenses against fatal infections and neoplastic diseases. Animal Models for AIDS

新的核和线粒体遗传标记已在不同物种中得到开发和描述，提高了我们评估物种内和物种间遗传变异模式以及重建历史进化事件的能力。结果表明，南美物种、豹子、山猫之间存在丰富的分子遗传多样性，而北美美洲狮、老虎、伊比利亚山猫以及之前记录的瓶颈猎豹、美洲狮和狮子的变异有限。对猫免疫缺陷病毒在自由放养的猫种群中传播的系统发育和系统地理学研究，可以让我们了解非常适合发现这些事件的物种中新出现的感染的过程。从这些研究中获得的见解揭示了针对致命感染和肿瘤疾病的免疫和自然防御的进化机制。 艾滋病动物模型