Sensory/Medical Core

感官/医疗核心

• 批准号: 6833785
• 负责人: BEVERLY J COWART
• 金额: $ 39.32万
• 依托单位: MONELL CHEMICAL SENSES CENTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6833785
• 关键词: biomedical facility; chemical hypersensitivity; clinical research; data management; histology; human subject; immunocytochemistry; informatics; mass spectrometry; medical outreach /case finding; neuropsychological tests; olfactory disorder; patient care management; patient care planning; statistics /biometry; taste disorders

The Sensory/Medical Core provides a stable center for the ongoing activities of the Chemosensory Clinical Research Center (CCRC) and support to the individual Projects associated with the Center. The Core assumes major responsibility for the assessment ofchemosensory function and dysfunction, and is key to the recruitment and consistent psychophysical and medical evaluation of patients participating in specific Projects. This Core also provides data management and statistical support to the Projects, and its laboratory, testing facilities and databases (which comprise extensive demographic, psychophysical and medical information on both normal and patient populations) are available to Project investigators. Finally, the Core serves as the focal point of interactions between basic research scientists at Monell and the clinical faculty of The Thomas Jefferson University. In addition, the Sensory/Medical Core maintains a clinical facility for the evaluation of referred patients who have primary complaints of abnormal smell or taste function. This Clinic serves to ground our CCRC and its investigators in the phenomenon that is at the heart ofchemosensory clinical research namely, chemosensory dysfunction. Through the operation of the Clinic, we have been able to assess the clinical utility of various methods of chemosensory testing, as well as to investigate such issues as the impact of chemosensory dysfunctions on patients, the etiologies of chemosensory dysfunctions and, through our comprehensive longitudinal follow-up program, the prognoses for chemosensory dysfunctions. In the proposed funding period, the Core's direct support to all Projects in the form of recruiting, scheduling, and evaluating participants is greatly expanded over previous years. We will also, however, continue our general clinical evaluations, given the great value of this work in yielding insights that serve to direct future research.

感觉/医疗核心为化学体临床研究中心（CCRC）的持续活动提供了一个稳定的中心，并为与该中心相关的各个项目提供了支持。核心对评估化学功能和功能障碍的评估负有主要责任，并且是参与特定项目的患者的招聘以及一致的心理物理和医学评估的关键。该核心还为项目提供了数据管理和统计支持，其实验室，测试设施和数据库（包括正常和患者人群的广泛人口，心理物理和医学信息）可用于项目研究人员。最后，核心 是Monell基础研究科学家与托马斯·杰斐逊大学临床教师之间相互作用的焦点。 此外，感觉/医学核心还维护了评估对异常气味或味觉功能的主要抱怨的转诊患者的临床设施。该诊所将我们的CCRC及其研究人员扎根于化学临床研究的核心，即化学感应功能障碍。通过诊所的运营，我们能够评估各种化学感觉测试方法的临床实用性，以及研究化学感功能障碍对患者的影响，化学感应功能障碍的病因，以及通过我们的全面纵向随访计划的化学感觉功能障碍的病因，对化学化学感应型的预测能力障碍性。 在拟议的资金期间，核心对所有项目的直接支持以招聘，调度和评估参与者的形式大大扩展。但是，鉴于这项工作的巨大价值在产生有助于未来研究的见解方面，我们还将继续进行一般的临床评估。