DRUG-RELATED CHANGES IN ORAL SENSORY PERCEPTION

与药物相关的口腔感官变化

• 批准号: 6104301
• 负责人: BEVERLY J COWART
• 金额: $ 2万
• 依托单位: MONELL CHEMICAL SENSES CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-02-15 至 1999-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6104301
• 关键词: behavioral /social science research tag; carbonic anhydrase inhibitors; drug adverse effect; eye agent; eye disorder chemotherapy; glaucoma; human subject; laboratory rat; perception; photostimulus; psychophysiology; saliva; single cell analysis; taste disorders

Despite considerable progress i our understanding of olfactory dysfunctions, there is still relatively little known about the causes of taste disorders. Medication usage, however, appears to be one of the most common etiologic factors contributing to disturbances in oral sensory perception. The proposed studies seek to elucidate both the nature and bases of taste aberrations associated with carbonic anhydrase inhibitors (CAIs). Through both acute studies with normal volunteers and a study of glaucoma patients receiving chronic CAI therapy, we will characterize psychophysically the nature of changes in oral sensory perception produced by CAIs. Acute studies will provide the experimental control necessary for detailed examination of the time course of these changes, as well as for parallel assessment of changes in salivary flow and buffering capacity that may be produced by CAIs and contribute to taste changes; a study of the acute effects of CAIs on salivary carbonic anhydrase activity is also proposed. The patients study will allow determination of the incidence and clinical implications of altered oral sensory perception secondary to CAI therapy. Finally, animal model studies are proposed to elucidate the neural mechanisms underlying the taste effects of CAIs. In addition to providing an understanding of taste alterations associated with carbonic anhydrase inhibition, the proposed studies should add to basic knowledge of factors contributing to gustatory transduction. More generally, they will shed light on the phenomenon of drug-induced alterations in taste by providing information regarding the specific types of changes that may occur, potential peripheral mechanisms for these changes, and their clinical implications.

尽管进步很大，但我对嗅觉的理解 功能障碍，关于原因 味道障碍。 但是，用药似乎是 最常见的病因因素导致口腔干扰 感官感知。 拟议的研究旨在阐明 与碳酸酐酶相关的味道畸变的性质和碱基 抑制剂（CAI）。 通过正常志愿者的急性研究和青光眼研究 接受慢性CAI治疗的患者，我们将表征 从心理上讲，口腔感觉感知变化的性质 由CAI产生。 急性研究将提供实验控制 详细检查这些变化的时间过程所必需的， 以及平行评估唾液流量变化和 CAI可能产生的缓冲能力并有助于口味 变化；研究CAI对唾液碳的急性影响的研究 还提出了赤道酶活性。 患者研究将允许 确定口腔改变的发生率和临床意义 感官感知继发于CAI治疗。 最后，动物模型 提出了研究以阐明依据的神经机制 CAI的味道影响。 除了提供对相关的口味改变的理解 随着碳酸酐酶的抑制作用，拟议的研究应增加 对导致味道转导的因素的基本知识。 更多的 通常，他们会阐明药物诱导的现象 通过提供有关特定的信息来改变口味 可能发生的变化类型，潜在的外围机制 这些变化及其临床意义。