CORE--SENSORY CORE

核心--感觉核心

• 批准号: 6651282
• 负责人: BEVERLY J COWART
• 金额: $ 26.25万
• 依托单位: MONELL CHEMICAL SENSES CENTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6651282
• 关键词: biomedical facility; chemoreceptors; clinical research; human subject; medical outreach /case finding; olfactions; olfactory disorder; olfactory stimulus; olfactory threshold; patient /disease registry; prognosis; psychophysiology; sensory disorder diagnosis; taste; taste disorders; taste threshold

The Sensory Core provides a stable center for the ongoing activities of the CCRC and support to the individual Projects associated with the Center. The Core assumes major responsibility for the assessment of chemosensory function and dysfunction. It has established a clinic to evaluate referred patients with complaints of abnormal smell or taste function, providing psychophysical, otolaryngological and oral health assessments. Through the clinic, we have been able, for example, to (1) characterize smell and taste disorders in a large sample of patients, (2) assess the clinical utility of various methods of chemosensory testing and develop procedures to provide new insights into the nature and degree of chemosensory dysfunction, (3) assess the impact of age on chemosensory dysfunction, and (4) establish a systematic patient follow-up program, which is beginning to yield information that will both broaden our understanding of various forms of chemosensory dysfunction and enable us to provide patients with accurate prognostic information. We propose to continue and expand these types of general clinical activities, building on projects begun in the current funding period (e.g., the development of a clinical test of retronasal olfactory function and of a questionnaire to assess the impact of chemosensory dysfunction on quality of life). The Core facility also serves a general resource for the CCRC and is critical to the success of clinical research projects, providing access to, and consistent chemosensory and otolaryngological evaluation of, defined patient populations. In the proposed renewal, the Core plays a key role in identifying, recruiting and testing patients and/or normal control subjects for individual Projects of the CCRC, and in coordinating Project activities.

感官核心为CCRC正在进行的活动提供了一个稳定的中心，并为与中心相关的各个项目提供了支持。核心对化学感应功能和功能障碍的评估负有主要责任。它已经建立了一家诊所，以评估引用的患者，患有异常气味或味觉功能，提供心理物理，耳鼻喉科和口腔健康评估。通过诊所，我们能够（1）在大量患者样本中表征气味和味觉疾病，（2）评估各种化学测试方法的临床实用性，并开发了对化学感觉障碍的性质和程度提供新的见解的新程序，（3）对年龄的影响进行了对体系的影响，以及（3）确定了对体系的影响，以及（4），（3）对4）的影响（4），4），（4），（3）两者都扩大了我们对各种形式的化学感觉功能障碍的理解，并使我们能够为患者提供准确的预后信息。我们建议继续并扩大这些类型的一般临床活动，这是基于当前资助期开始的项目（例如，开发促进后嗅觉功能的临床测试以及评估化学感觉障碍对生活质量的影响的问卷调查）。该核心设施还为CCRC提供了一般资源，对于临床研究项目的成功至关重要，为定义的患者人群提供了访问和一致的化学感应和耳鼻喉科评估。在拟议的续约中，核心在识别，招募和测试患者和/或正常对照对象的CCRC各个项目以及协调项目活动方面起着关键作用。