ADHERENCE AND RETENTION CORE

坚持和保留核心

• 批准号: 6847367
• 负责人: JACQUELINE M DUNBAR-JACOB
• 金额: $ 11.36万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6847367
• 关键词: aging; balance; biomedical facility; geriatrics; health care referral /consultation; health science research support

The goal of the Adherence and Retention Core (ARC) is to provide consultation and advice on strategies to promote adherence and increase retention in order to enhance successful completion of clinical studies of balance and mobility. Related to this is the goal of improving measurement of adherence and retention within clinical studies to facilitate the interpretation of treatment outcomes as well as to examine the moderation of outcomes by level of patient participation. Current research on adherence demonstrates poor adherence with behavioral and pharmacologic treatment regimens even among well elders, with as up to 50% of patients not following pharmacological regimens and as few as 25% of patients continuing prescribed exercise regimen at one year. Little is known about adherence with balance exercise in mobility impaired older adults. Poor adherence attenuates treatment outcome relationships, thus reducing the ability to detect treatment effects as well as treatment side effects. Subject retention is also a significant problem. Loss of subjects poses significant threats to power within studies and is particularly problematic when biases occur in drop out rates. Loss of subjects may attenuate the delivery of intervention through early termination of treatment and/or may contribute to significant loss of data at the end of the trial. In either case, power is lost within the study. Efforts to enhance adherence and retention are important components of clinical trial design and conduct. The purpose of the Adherence and Retention core will be to consult and advise investigators within the center on strategies and techniques to prevent adherence and retention problems in OAIC projects as well as to provide advice and consultation on improving adherence and retention should ongoing studies find that these rates are suboptimal. The Specific Aims of the Adherence and Retention Core are to: 1. Provide consultation and advice to investigators regarding the design and development of adherence and retention components of new projects and the support of ancillary studies addressing adherence and retention issues in ongoing funded projects; as well as advice on the improvement of retention and adherence in ongoing studies; 2. Provide access to relevant literature on assessment strategies and intervention protocols as well as general literature on adherence through the maintenance and enhancement of a library of such resources, and access to assessment technologies for evaluation and training purposes; 3. Develop new strategies and technologies beyond the current capabilities of the existing knowledge, addressing the unique needs of the older adult through the design and conduct of developmental studies; and 4. Support the research training mission of the OAIC through the training of investigators and staff in the impact of poor adherence and retention on interpretation of study outcomes; the use of strategies and technology to promote adherence and retention; and measurement strategies for assessing adherence and retention in clinical studies.

依从性和保留核心（ARC）的目的是提供有关咨询和建议 促进依从性并增加保留率的策略，以增强对平衡和流动性的临床研究的成功完成。与此相关的目的是改善临床研究中依从性和保留率的测量，以促进治疗结果的解释，并通过患者参与水平来检查结局的适度。当前对依从性的研究表明，即使在夫妻级的长者中，行为和药理治疗方案的依从性也很差，其中多达50％的患者不遵循药理治疗方案，只有多达25％的患者在一年中继续开处方运动方案。关于在流动性障碍的老年人中，依从性遵守依从性，对老年人的依从性知之甚少。依从性差会削弱治疗结果关系，从而降低了检测治疗效果以及治疗副作用的能力。主题保留也是一个重大问题。受试者的丧失会对研究中的权力构成重大威胁，当辍学率中发生偏见时，尤其是有问题的。受试者的丧失可能会通过早期终止治疗和/或可能导致干预措施的提供 试验结束时的数据丢失。无论哪种情况，在研究中都会损失权力。提高依从性和保留率的努力是临床试验设计和行为的重要组成部分。依从性和保留核心的目的将是在策略和技术中咨询和建议调查人员，以防止OAIC项目中的依从性和保留问题，以及提供有关改善依从性和保留率的建议和咨询，应该发现这些速度是次优的。 依从性和保留核心的具体目的是： 1。向调查人员提供有关设计和开发的咨询和建议 新项目的依从性和保留组成部分以及辅助研究的支持，以解决正在进行的资助项目中的依从性和保留问题；以及有关正在进行的研究中的保留和依从性的建议； 2.提供有关评估策略和干预协议的相关文献，以及通过维护和增强此类资源库的依从性，以及访问评估技术以进行评估和培训目的的一般文献； 3。制定超出现有功能的新策略和技术 知识，通过设计和行为来满足老年人的独特需求 发展研究；和 4.通过培训研究人员和员工的培训，支持OAIC的研究培训使命，从而对依从性和保留对研究结果的解释的影响；使用战略和技术来促进依从性和保留；以及评估临床研究中依从性和保留率的测量策略。