Acquisition of a 9.4T Small Animal MRI/MRS System

购置9.4T小动物MRI/MRS系统

• 批准号: 6580570
• 负责人: JOHN C GORE
• 金额: $ 50万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6580570
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; magnetic resonance imaging

DESCRIPTION (provided by applicant): This application from Vanderbilt University seeks partial funding for the acquisition of a state-of-the-art, high field (9.4T) Magnetic Resonance Imaging/Spectroscopy system that will be used to extend and improve various research programs involving small animals. This system is essential for several current NIH-funded projects including studies of tumor biology, neural function and development, diabetes, alcoholism and transgenic mice. It is also essential for several projects that involve fundamental studies related to the further development and application of MRI methods in medicine. The proposed facility will provide a major new capability for in vivo imaging and spectroscopy and thereby will permit current NIH-funded investigators to undertake studies which are essential for their projects but which are currently unable to be performed without this instrument. Several previous studies have been obtained using an existing and antiquated 4.7T system that has numerous technical limitations and which is not able to provide the quality of information needed for these projects. The new, higher field instrument will acquire images and spectra that have inherently higher signal to noise ratios, greater spatial and spectral resolution, and images, which are more sensitive to some contrast mechanisms. The proposed system will have a much better shim and gradient system and associated hardware, and will be based around a modern console and spectrometer capable of a wider array of modern experiments. These new capabilities will include fast and 3D imaging that is important for a variety of experiments, improved diffusion weighted imaging, and broadband multi-nuclear (H-1, P-31 and C-13) in vivo MR spectroscopy for studies of metabolism. The system will be an integral part of a new Center dedicated to research imaging and will be supported by a large and experienced group of physicists, engineers and computer scientists, along with a well trained and qualified group of support staff, including electronic engineers and animal technologists. These technical experts will take responsibility for assisting users in experimental design, data acquisition and data analysis. The proposed instrument will be a multi-user facility, supervised by a director and a core staff, developed and managed via an operating committee, and with oversight by an advisory committee charged with the responsibility of assuring appropriate access to NIH funded investigators. The acquisition of the proposed instrument will significantly increase the number and quality of investigations using small animal MRI and MRS and in turn will help Vanderbilt University meet its commitment to enhancing bench-to-bedside research in the areas of basic cancer biology and cancer therapy, neuroscience, structural biology and genetics.

描述（由申请人提供）： 范德比尔特大学（Vanderbilt University）的这一应用程序寻求部分资金来获取最先进的高场（9.4T）磁共振成像/光谱系统，该系统将用于扩展和改善涉及小动物的各种研究计划。该系统对于当前的几个NIH资助的项目至关重要，包括研究肿瘤生物学，神经功能和发育，糖尿病，酒精中毒和转基因小鼠。对于几个涉及与MRI方法在医学中进一步开发和应用有关的基础研究的项目，这也是必不可少的。拟议中的设施将为体内成像和光谱法提供一个主要的新能力，从而使现任NIH资助的研究人员能够进行对其项目至关重要的研究，但目前没有该工具就无法执行。使用现有且过时的4.7T系统获得了一些先前的研究，该系统具有许多技术限制，并且无法提供这些项目所需的信息质量。新的高场仪器将获取具有固有的信号与噪声比，更大的空间和光谱分辨率以及图像的图像和光谱，这些图像对某些对比机制更为敏感。所提出的系统将具有更好的垫片和梯度系统和相关的硬件，并将基于现代控制台和光谱仪，能够提供更广泛的现代实验。这些新功能将包括快速和3D成像，对于各种实验很重要，改进的扩散加权成像以及体内MR光谱中的宽带多核（H-1，P-31和C-13），用于代谢研究。该系统将是致力于研究成像的新中心不可或缺的一部分，并将得到一大批又有经验丰富的物理学家，工程师和计算机科学家组的支持，以及训练有素且合格的支持人员组，包括电子工程师和动物技术人员。这些技术专家将负责帮助用户进行实验设计，数据获取和数据分析。拟议的工具将是由董事和核心人员监督的多用户设施，并通过运营委员会开发和管理，并由咨询委员会监督，负责确保与NIH资助的调查人员进行适当的访问权。拟议工具的获取将大大提高使用小动物MRI和MRS的调查数量和质量，进而将有助于范德比尔特大学达到增强基本癌症生物学和癌症治疗领域的基准对卧铺研究的承诺，神经科学，结构生物学和遗传学。