Whole-head MEG System

全头脑磁图系统

• 批准号: 6879820
• 负责人: ROLAND Robert LEE
• 金额: $ 50万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-15 至 2006-01-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6879820
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; biomedical equipment resource; brain imaging /visualization /scanning; electroencephalography; functional magnetic resonance imaging; head; magnetoencephalography

DESCRIPTION (provided by applicant): The instrument requested is a whole-cortex high-density magnetoencephalography (MEG) system. The system also will record up to 128 channels of EEG simultaneously. It will be located within a high-performance magnetically shielded room, and will have additional software and hardware features to permit recordings of cortical activity with excellent signal to noise. The system will include behavioral stimulation equipment and computers to control perceptual, cognitive and motor experiments as well as clinical studies. The proposed instrument will be located at UCSD's Center for Functional Magnetic Resonance Imaging (CFMRI), and will be operated and administered through the existing infrastructure of the CFMRI. The CFMRI already is the hub of a broad research effort in functional MRI (fMRI) that serves many NIH-funded research programs. Major Users of the proposed MEG instrument come from the Radiology, Psychiatry, Neuroscience, and Cognitive Science Departments at UCSD, as well as from UCIrvine. MEG directly and instantaneously reflects synaptic current flows. It thus has excellent temporal resolution to complement the excellent spatial resolution provided by fMRI. The faculty and staff of the CFMRI provide a wide range of relevant expertise, including advanced techniques for localizing distributed cortical sources by integrating MEG and EEG with structural and functional MRI. The featured NIH-supported projects that will immediately benefit from the MEG system include studies of selective attention and language in normal subjects, as well as the changes in cognitive function that occur in autism, normal aging, Alzheimer's disease and early focal brain damage. Other studies explore novel methods for analyzing MEG signals, their underlying physiological bases, and their relation to the BOLD effect.

描述（由申请人提供）：请求的仪器是全皮层高密度磁脑摄影（MEG）系统。该系统还将同时记录多达128个脑电图。它将位于磁性屏蔽的高性能室内，并将具有其他软件和硬件功能，以允许录制皮质活动，并具有出色的噪声信号。该系统将包括行为刺激设备和计算机，以控制感知，认知和运动实验以及临床研究。该拟议的仪器将位于UCSD的功能磁共振成像中心（CFMRI），并将通过CFMRI的现有基础架构进行操作和管理。 CFMRI已经是功能性MRI（fMRI）的广泛研究工作的枢纽，该工作为许多NIH资助的研究计划提供了服务。拟议的MEG工具的主要用户来自UCSD的放射学，精神病学，神经科学和认知科学部门以及Ucirvine。 MEG直接，即时反映突触电流流动。因此，它具有出色的时间分辨率，可以补充fMRI提供的出色空间分辨率。 CFMRI的教职员工提供了广泛的相关专业知识，包括通过将MEG和EEG与结构和功能性MRI相结合，用于定位分布式皮质来源的高级技术。由NIH支持的项目将立即受益于MEG系统，包括对正常受试者的选择性注意和语言的研究，以及自闭症，正常衰老，阿尔茨海默氏病和早期局灶性脑损伤的认知功能的变化。其他研究探讨了分析MEG信号，其潜在生理基础的新方法以及它们与大胆效应的关系。