Postdoctoral Training in Biomedical MRI and MRS

生物医学 MRI 和 MRS 博士后培训

• 批准号: 6697384
• 负责人: JOHN C GORE
• 金额: $ 18.62万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6697384
• 关键词: Postdoctoral; Training; Biomedical; MRI; MRS

DESCRIPTION (provided by applicant): This application seeks support for a comprehensive postdoctoral training program in magnetic resonance imaging (MRI) and spectroscopy (MRS) at Vanderbilt University which will be provided by an experienced and expert group of faculty and research staff. MR methods are well established as amongst the most powerful and widespread of biomedical imaging techniques yet major advancements in technology and increases in their impact continue to occur. MR methods serve not only as the single most important modality in diagnostic imaging but also provide crucial insights into biological processes and structure to address fundamental questions in biomedical research. Advanced MR systems for research are available at a large number of medical centers, and further advances in their uses will occur inevitably as systems with stronger field magnets become more widespread. There is, however, a shortage and a critical need for appropriately trained scientists capable of exploiting the potential of MR techniques, who are aware of the uses and limitations of MR methods, and of how MRI/MRS may be implemented, advanced, and integrated with information available from other modalities. We propose a comprehensive training program designed for 8 outstanding postdoctoral scientists (4 in each of a two-year program) who will usually have had little previous significant experience in biomedical MRI and MRS. Postdoctoral trainees from physics, chemistry, biology, engineering or medicine will receive thorough and exemplary instruction in all of the cognate areas relevant to biomedical NMR in a coherent program that includes 18 Ph.D faculty experienced in biomedical MRI/S and their applications. This will be accomplished through an educational program, consisting of courses, seminars, and journal clubs; a practical program, consisting of faculty-led tutorials and practical training; and a research program, in which trainees will be integrated into an active research program. These programs illustrate most major aspects of the applications of MR methods in humans and animals and include functional and structural brain imaging, cancer biology, studies of basic relaxation phenomena and diffusion, blood flow and perfusion, metabolic imaging, image processing and analysis, and clinical MRS and MRI. Trainees will have access to outstanding facilities including human MR systems with field strengths of 1.5, 3, and 7T; animal MR systems of 4.7, 7, and 9.4T; and other imaging modalities (including optical imaging, microCT, and microPET). Trainees will be mentored in the ethics and methods of biomedical research, as well as in grant writing and other important career skills. The programs, personnel, and facilities at Vanderbilt provide unique opportunities for scientists to receive advanced training in biomedical NMR of the highest caliber, and will help to ensure that the remarkable insights into biology and disease that are possible with MRI and MRS will be realized.

描述（由申请人提供）：本申请寻求对范德比尔特大学磁共振成像（MRI）和光谱学（MRS）综合博士后培训计划的支持，该计划将由经验丰富的专家组教师和研究人员提供。 MR 方法已被公认为是最强大、最广泛的生物医学成像技术之一，但技术的重大进步及其影响力仍在不断增加。 MR 方法不仅是诊断成像中最重要的一种方式，而且还提供对生物过程和结构的重要见解，以解决生物医学研究中的基本问题。 许多医疗中心都提供用于研究的先进 MR 系统，随着具有更强磁场的系统变得更加普遍，其使用将不可避免地出现进一步发展。 然而，缺乏且迫切需要经过适当培训的科学家，他们能够利用 MR 技术的潜力，了解 MR 方法的用途和局限性，以及如何实施、推进和集成 MRI/MRS以及从其他方式获得的信息。 我们提出了一项针对 8 名优秀博士后科学家（每个两年计划 4 名）的综合培训计划，他们通常在生物医学 MRI 和 MRS 方面几乎没有丰富的经验。 来自物理、化学、生物学、工程或医学的博士后学员将在一个连贯的项目中接受与生物医学 NMR 相关的所有同源领域的全面和示范性指导，该项目包括 18 名在生物医学 MRI/S 及其应用方面经验丰富的博士教师。 这将通过教育计划来实现，包括课程、研讨会和期刊俱乐部；实践计划，包括教师主导的教程和实践培训；以及一个研究计划，受训者将被纳入一项活跃的研究计划。 这些项目说明了 MR 方法在人类和动物中应用的大多数主要方面，包括功能和结构脑成像、癌症生物学、基本松弛现象和扩散的研究、血流和灌注、代谢成像、图像处理和分析以及临床MRS 和 MRI。 学员将能够使用一流的设施，包括场强为1.5、3和7T的人体MR系统； 4.7、7、9.4T动物MR系统；和其他成像方式（包括光学成像、microCT 和 microPET）。 学员将接受生物医学研究伦理和方法以及资助写作和其他重要职业技能方面的指导。 范德比尔特大学的项目、人员和设施为科学家提供了接受最高水平生物医学 NMR 高级培训的独特机会，并将有助于确保通过 MRI 和 MRS 实现对生物学和疾病的非凡见解。