Small Animal Handling Devices for Multiplatform Imaging

用于多平台成像的小动物处理设备

• 批准号: 6789574
• 负责人: STANLEY THOMAS FRICKE
• 金额: $ 14.7万
• 依托单位: ASI INSTRUMENTS, INC
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2005-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6789574
• 关键词: animal colony; bioimaging /biomedical imaging; biomedical equipment; biomedical equipment development; image processing; imaging /visualization /scanning; monitoring device; neurosciences; radiology; restraint; stereotaxic techniques; surgery

DESCRIPTION (provided by applicant): Small animal imaging initiatives are growing rapidly due to the enormous potential for improved understanding and treatment of human disease through animal imaging. At present, every radiologic modality available for use in humans has been adapted for small animal use. Other modalities have been devised solely for the purpose of in vivo imaging of research animals. As investigators increasingly make use of small animal imaging, the need for improved and standardized animal handling technology is critical. Our research goal is to create and distribute animal handling systems that are robust, safe, easy to use, and able to provide high-quality radiological images across multiple imaging platforms including MRI, CAT, PET and SPECT. The Specific Aims are to (1) Test and improve a stereotaxic rodent holder for rat and mouse head imaging, (2) Test and enhance animal monitoring and physiological support for the modular animal handling system, and (3) Evaluate the ability to use the rodent holder in multi-modality imaging applications. This proposed research is the result of a partnership between a small business specializing in the manufacture of animal handling devices (ASI Instruments, Inc.) and a university based research team (Neurobiological Magnetic Resonance Imaging Laboratory, Department of Neuroscience, Georgetown University). This industry/academic partnership will merge of the technology of stereotaxic instrumentation, typically used for the precise anatomical alignment needed in surgical procedures, and the technology of radiological imaging, in order to precisely align small animals to the orthogonal imaging planes of medical imaging equipment. Knowledge gained from this Phase I study will be used in Phase II for developing animal holders for other animals and for purposes other than imaging the brain of these animals (e.g. skeletal muscle, spinal cord, heart, lung, etc.).

描述（由申请人提供）：由于通过动物成像提高对人类疾病的理解和治疗的巨大潜力，小动物成像计划正在迅速发展。目前，每一种可用于人类的放射学方式都已适用于小动物。其他模式的设计仅仅是为了研究动物的体内成像。随着研究人员越来越多地使用小动物成像，对改进和标准化动物处理技术的需求至关重要。我们的研究目标是创建和分发坚固、安全、易于使用的动物处理系统，并能够在多个成像平台（包括 MRI、CAT、PET 和 SPECT）上提供高质量的放射图像。具体目标是 (1) 测试和改进用于大鼠和小鼠头部成像的立体定位啮齿动物​​支架，(2) 测试和增强模块化动物处理系统的动物监测和生理支持，以及 (3) 评估使用该系统的能力多模态成像应用中的啮齿动物支架。这项拟议的研究是一家专门生产动物处理设备的小企业（ASI Instruments, Inc.）和一个大学研究团队（乔治城大学神经科学系神经生物学磁共振成像实验室）合作的结果。这种行业/学术合作伙伴关系将融合立体定位仪器技术（通常用于外科手术所需的精确解剖对准）和放射成像技术，以便将小动物精确对准医学成像设备的正交成像平面。从第一阶段研究中获得的知识将用于第二阶段，为其他动物开发动物支架，以及用于这些动物大脑成像以外的其他目的（例如骨骼肌、脊髓、心脏、肺等）。