Bio-Effects of Ultra-High MRI Gradient Slew Rates

超高 MRI 梯度转换率的生物效应

• 批准号: 8059465
• 负责人: STANLEY THOMAS FRICKE
• 金额: $ 82.33万
• 依托单位: WEINBERG MEDICAL PHYSICS, LLC
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8059465
• 关键词: 3-Dimensional; Achievement; Acoustic Stimulation; Acoustics; Adoption; Adult; Animals; Brain; Brain imaging; Capital; Childhood; Clinical; Clinical Research; Clinical Trials; Collection; Commit; Computer software; Country; Development; Devices; Diagnostic; Diffusion Magnetic Resonance Imaging; Ear; Equipment; Exposure to; Fiber; Frequencies; Functional Magnetic Resonance Imaging; Goals; Health Care Costs; Human; Human Volunteers; Image; Imagery; Imaging Phantoms; Institutional Review Boards; Isotropy; Knowledge; Lead; Life; Loudness; Magnetic Resonance Imaging; Magnetism; Measures; Medical; Medical Technology; Morphologic artifacts; Motion; Motivation; Nerve; Nervous system structure; Neurologic; Noise; Optic Nerve; Pain; Patients; Performance; Phase; Physics; Physiologic pulse; Polyesters; Publishing; Relaxation; Research Personnel; Resolution; Sampling; Scanning; Sedation procedure; Signal Transduction; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Speed; Structure; Swimming; System; Techniques; Technology; Testing; Time; United States National Institutes of Health; Vertebrates; Water; Width; Work; Zebrafish; base; high standard; human tissue; image visualization; improved; in vivo; magnetic field; meter; millimeter; multidisciplinary; new technology; novel; operation; programs; radiologist; sample fixation; software development; white matter

DESCRIPTION (provided by applicant): This application represents a competing renewal request for a Phase II STTR project, in which we constructed an ultra-fast gradient system for magnetic resonance imaging. Operation of the novel system is based upon the principle that the nervous system is relatively insensitive to very short exposures to changing magnetic fields. As a result, we are showing in clinical trials that magnetic slew rates (i.e., changes in gradients per time) can be 1,000 times faster than are currently available in clinical MRI scanners, and deliver magnetic gradients 10 times higher, without painful stimulation. The purpose of this competing renewal is to take the technology to the level of FDA approval. Based on well-established principles of MRI physics, it stands to reason that the increased gradient strength and shorter pulse sequences permitted by the new technology will have multiple meaningful benefits to users of clinical and research systems, including overall decreased acquisition time, reduction in acoustic noise, and elimination of artifacts due to subject motion. The multidisciplinary team assembled for this project includes MRI physicists, pediatric and general radiologists, and neuroscientists, experts in pulsed power technology, medical capital equipment entrepreneurs, and committed technical representatives of potential strategic partners active in this field. The team has worked well together over the past five years to achieve significant achievements, and has collaborated in the past to launch four medical products with the aid of the NIH SBIR program. Milestones to be accomplished in this project include adaptation of the system to a 7-Tesla animal MRI scanner and a clinical 3-Tesla system, visualization of post-mortem human tissues and moving vertebrate animals, FDA-mandated human trials of nervous stimulation and acoustic noise, and high- resolution tractography and functional MRI of the human brain in vivo. From a commercial point of view, configuring the product as a replacement upgrade to existing MRI systems has been a very successful financial strategy for several companies, one of which has committed to assisting us in this effort. Potential benefits to the country include health-care cost reduction (as a result of reduced scan-times per patient), increased scientific knowledge and diagnostic confidence as we examine smaller features of the nervous system, export potential of advanced medical products, and improved patient comfort (as we reduce acoustic noise and the need for sedation of pediatric and adult subjects). PUBLIC HEALTH RELEVANCE: Potential benefits to the country include health-care cost reduction (as a result of reduced scan- times per patient), increased scientific knowledge and diagnostic confidence as we examine smaller features of the nervous system, export potential of advanced medical products, and improved patient comfort (as we reduce acoustic noise and the need for sedation of pediatric and adult subjects).

描述（由申请人提供）：此申请代表了II期STTR项目的竞争续订请求，在该项目中，我们构建了用于磁共振成像的超快速梯度系统。新系统的运行是基于以下原则：神经系统对变化磁场的非常短的暴露相对不敏感。结果，我们在临床试验中表明，磁性回旋速率（即每次梯度的变化）的速度比临床MRI扫描仪中目前可用的速度快1000倍，而没有疼痛刺激的磁性梯度高10倍。这种竞争更新的目的是将技术提高到FDA批准的水平。基于MRI物理学的完善原则，它有理由认为，新技术允许的梯度强度和较短的脉冲序列将对临床和研究系统的使用者具有多种有意义的好处，包括总体上减少的获取时间，降低声学噪声的减少以及由于受试者而导致的伪影。为该项目组成的跨学科团队包括MRI物理学家，儿科和普通放射科医生以及神经科学家，脉冲电力技术专家，医疗资本设备企业家以及潜在的战略合作伙伴的技术代表。在过去的五年中，该团队共同努力，以取得重大成就，并在过去的NIH SBIR计划的帮助下合作推出了四种医疗产品。在该项目中要完成的里程碑包括将系统适应为7台拉动动物MRI扫描仪和临床3-Tesla系统，可视化后人类组织和移动脊椎动物动物，FDA对人类神经刺激和声音噪声的人体试验以及高分辨率的术语和高分辨率的术语和高分辨率的MRI MRI人类脑脑中的大脑。从商业角度来看，将产品配置为现有MRI系统的替代升级一直是多家公司的一项非常成功的财务策略，其中一家公司致力于协助我们进行这项工作。该国的潜在收益包括降低医疗保健成本（由于每位患者的扫描时间减少），科学知识和诊断信心的增加，因为我们检查了神经系统的较小特征，高级医疗产品的出口潜力以及改善患者的舒适感（随着我们减少声学噪音以及对儿科和成人受试者镇静的需求）。 公共卫生相关性：该国的潜在收益包括降低医疗费用（由于每位患者的扫描减少），科学知识的增加和诊断信心，因为我们检查了神经系统的较小特征，高级医疗产品的出口潜力以及改善患者的舒适性（随着我们的声音降低，降低声学噪音以及对儿童和成人受试者的待安需要）。