Delaware Center for Musculoskeletal Research – Multiscale Assessments Research Core

特拉华州肌肉骨骼研究中心 — 多尺度评估研究核心

• 批准号: 10352303
• 负责人: LIYUN WANG
• 金额: $ 73.35万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10352303
• 关键词: Animals; Basic Science; Biological; Biological Models; Biological Sciences; Biomechanics; Biomedical Research; Biophysics; Biostatistics Core; Biotechnology; Communities; Competence; Computers and Advanced Instrumentation; Cues; Delaware; Disease; Educational workshop; Engineering; Ensure; Equipment; Functional disorder; Funding; Goals; Health; Image; Individual; Institutes; Lead; Leadership; Measurement; Methodology; Molecular; Musculoskeletal; Organism; Pre-Clinical Model; Reproducibility; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Scientist; Services; Signal Transduction; Structure; Technical Expertise; Techniques; Therapeutic Intervention; Tissues; Training; Universities; Work; bioimaging; biomechanical model; biophysical model; design; in vivo imaging; instrument; instrumentation; mechanical load; pre-clinical; pre-clinical research; programs; response; square foot; success

Project Summary / Abstract The Delaware Center for Musculoskeletal Research (DCMR) will support basic and preclinical research on the central theme of musculoskeletal health and disorders, from the level of the entire body to the molecule, with an emphasis on the mechanisms by which physical and biological cues influence tissue structure and normal function, dysfunction, and potential therapeutic interventions. Unraveling the interconnected responses at multiple levels will require an integrated application of advanced biomechanical and bioimaging techniques with preclinical (animal) and biophysical (explant) model systems. This requirement is not easily met using standard instrumentation typically available in research centers, and state-of-the-art equipment, technical expertise to use this equipment, and scientific expertise across multiple platforms to guide the design and application of these techniques is needed. The goal of the Multiscale Assessments Research Core is to maximize the success and impact of DCMR Research Project, Project Leaders, and other researchers by providing a Research Core that includes state-of- the-art equipment to apply and assess physical cues and biological signals. The Core will use a gateway organizational framework that is built around interlinked scientific leadership, technical expertise, user training, and partnerships with existing collaborative Centers. The Research Core will provide, develop, and support multiscale mechanical loading and measurement capability, expertise, and training (Aim 1); provide, develop, and support preclinical and biophysical models, including assessment capability, expertise, and training (Aim 2); and enhance the existing Bioimaging Center (Aim 3). The Research Core will obtain new state-of-the-art equipment, including the construction of new instruments to apply physical cues and molecular signals to living systems and the purchase of advanced instrumentation for in vivo imaging. The Research Core will be housed in a newly renovated 1400 sq. ft. lab space adjacent to the vivarium. The coordination of musculoskeletal resources and expertise in the DCMR Multiscale Assessments Research Core will accelerate the research pace for Project Leaders and Center users. The use of Core’s resources for research questions at the interface of engineering and life sciences will have a synergistic effect that will strengthen UD’s biomedical research infrastructure and impact.

项目摘要 /摘要 特拉华州肌肉骨骼研究中心（DCMR）将支持有关基础和临床前研究 从整个身体的水平到分子的肌肉骨骼健康和疾病的中心主题， 强调物理和生物线索影响组织结构和正常的机制 功能，功能障碍和潜在的治疗干预措施。揭示互连的响应 多个级别将需要与高级生物力学和生物成像技术的集成应用 临床前（动物）和生物物理（爆炸性）模型系统。使用标准不容易满足此要求 仪器通常可在研究中心和最先进的设备，技术专业知识中提供 该设备以及跨多个平台的科学专业知识，以指导这些设备的设计和应用 需要技术。 多尺度评估研究核心的目标是最大化DCMR的成功和影响 研究项目，项目负责人和其他研究人员提供的研究核心包括 用于申请和评估物理线索和生物信号的设备。核心将使用网关 组织框架围绕着相互联系的科学领导，技术专长，用户培训， 以及与现有协作中心的合作伙伴关系。研究核心将提供，发展​​和支持 多尺度机械负载和测量能力，专业知识和培训（AIM 1）；提供，发展​​， 并支持临床前和生物物理模型，包括评估能力，专业知识和培训（AIM 2）;并增强现有的生物成像中心（AIM 3）。 研究核心将获得新的最新设备，包括建造新仪器 将物理线索和分子信号应用于生存系统和购买高级仪器 用于体内成像。研究核心将安置在新近翻新的1400平方英尺的实验室空间中 Vivarium。 DCMR多尺度评估中肌肉骨骼资源和专业知识的协调 研究核心将为项目负责人和中心用户加速研究空间。核心的使用 工程和生命科学界面上的研究问题资源将产生协同效果 这将加强UD的生物医学研究基础设施和影响。