A Novel High-Intensity Area X-ray Source

一种新型高强度面X射线源

• 批准号: 6790739
• 负责人: Ivan Nesch
• 金额: $ 10万
• 依托单位: NESCH, LLC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2005-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6790739
• 关键词: X ray; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical device power system; biomedical equipment development; clinical biomedical equipment; densitometry; electrodes; electron optics; electron radiation; energy source; image enhancement; imaging /visualization /scanning; technology /technique development

DESCRIPTION (provided by applicant): Diffraction enhanced imaging (DE I) is a novel approach to X-ray imaging, which can revolutionize X-ray medical imaging, because of its greater contrast at lower X-ray doses than conventional radiography. DEI relies on measuring tiny angular deflections of a collimated X -ray beam as it passes through the object (patient) in acquiring the images. The capability of DEI detecting low-density features in low-density matrices will make it especially useful in medical diagnoses and research. An essential prerequisite for optimizing DEI and using it with highly reproducible and predictable precision in a routine application such as medical applications is to have sufficiently intense X-ray source. Such are only available at synchrotron sources or possibly with very high-power rotating anode X-ray sources, which are expensive to purchase and complex to operate. The potential impact of this technology in medical imaging research, and subsequently in clinical use, will far exceed the current or projected capacity of available synchrotron beam lines. The use of DEI in clinical or laboratory settings will create an unprecedented market for specialty high-intensity X-ray sources. Unlike most X-ray imaging methods, DEI does not require a point source of radiation. Furthermore, DEI can fully use a line source due to its use of diffracting crystal optics, while having extremely high resolution in one direction defined by the projected source line width, and in the other defined by the detector resolution. Therefore, production of a high-intensity line X-ray source is of primary importance for widespread DEI application. In general, our goal is to enable the implementation of DEI in different areas such as clinical settings outside the synchrotron facilities. Specifically we propose to: 1) Design, bulled, and test a novel, stationary anode, area X-ray source (50 mm x 12 mm electron impact area) for much higher intensity X-ray emission than is currently feasible from a sealed X-ray source by employing dispenser emitter cathodes (not known to have been used in similar applications before), and 2) Experimentally characterize the uniformity, stability and reliability of the source performance over extended periods of time. Based on the knowledge and the experience we have, we are confident that the approach we will take is realistic and feasible. At the completion of the proposed Phase I project, we anticipate the following results: 1. A working alpha prototype (system). 2. A performance characterization of the system.

描述（由申请人提供）： 衍射增强成像（DE I）是一种新型的X射线成像方法，可以彻底改变X射线医学成像，因为它在较低的X射线剂量时比传统的放射线摄影更大。 DEI依赖于测量准直的X射线光束在获取图像时穿过物体（患者）时的微小角度挠度。 DEI检测低密度矩阵中低密度特征的能力将使其在医学诊断和研究中特别有用。在常规应用程序（例如医疗应用程序）中，优化DEI并以高度可重复和可预测的精度使用它的基本先决条件是具有足够强烈的X射线源。仅在同步源可用，或者可能具有非常高的旋转阳极X射线源，这些资源很昂贵，并且运行且运行很复杂。该技术在医学成像研究中的潜在影响以及随后在临床使用中的潜在影响将远远超过可用同步器束线的当前或投影能力。在临床或实验室环境中使用DEI将为专业高强度X射线源创造前所未有的市场。与大多数X射线成像方法不同，DEI不需要辐射点源。此外，DEI由于使用衍射晶体光学元件，可以完全使用线源，同时在由投影源线宽度定义的一个方向上具有极高的分辨率，而在另一个方向上，在检测器分辨率下定义的另一个方向。因此，高强度线X射线源的生产对于广泛的DEI应用至关重要。通常，我们的目标是使DEI在同步器设施外的临床环境等不同领域实施。具体而言，我们提出：1）设计，欺负和测试一种新型的固定阳极，面积X射线源（50 mm x 12 mm电子冲击区域）的强度更高的X射线排放比目前可在密封的X射线源中可行的X射线发射要高得多，并且通过使用分配器Emitter Emitter Patter（未知在类似的应用中）使用过的效果，并且在相似的应用程序中使用了相似的表现，并且均不独特地表现出典型的表现，并构成了典型的表现，并且该典型的表现均匀且典型的表现量，并且该典型的表现均匀且典型的表现，并且均匀的典型范围和典型的表现量，并且均匀的表现量，并构成了典范的典范。时间。根据我们拥有的知识和经验，我们相信我们将采取的方法是现实和可行的。在拟议的I期项目完成时，我们预计会有以下结果：1。工作alpha原型（系统）。 2。系统的性能表征。