Complex Sound Processing in the Human Temporal Lobe

人类颞叶的复杂声音处理

• 批准号: 6769626
• 负责人: Dana F. Boatman
• 金额: $ 26.04万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6769626
• 关键词: auditory discrimination; auditory stimulus; behavioral /social science research tag; brain mapping; clinical research; direct cortical response; electrocorticography; epilepsy; human subject; neural information processing; sound frequency; sound perception; speech; speech recognition; stimulus /response; temporal lobe /cortex

DESCRIPTION: (provided by applicant): The long-term goal of this research is to understand the organization of complex sound processing in the human lateral temporal lobe. We will focus on temporal lobe processing of complex frequency-modulated (FM) sounds, including speech. The ability to discriminate FM sounds that differ in rate and direction of frequency change is integral to many auditory behaviors, including speech perception. The main hypothesis motivating this research is that a subsystem within the lateral temporal lobe is specialized for discriminating complex FM sounds. It is further hypothesized that absence of functional specialization is associated with auditory processing abnormalities. We will test these hypotheses by combining functional lesion (cortical stimulation) and neurophysiologic (electrocorticography) methods with an auditory discrimination paradigm, to study seizure patients with electrodes implanted subdurally for clinical purposes. Preliminary studies have confirmed the feasibility of the methodologies proposed.The specific aims are to: 1) delineate lateral temporal lobe regions that are critical for complex FM sound discrimination; 2) quantify variability in the temporal lobe representations of complex FM sound discrimination in normal and abnormal central auditory systems; and 3) identify spatial and temporal features of electrocorticographic responses that suggest specialization for complex FM sound processing. The significance of this research includes a better understanding of the functional organization of the lateral temporal lobe system and the associated effects of variability. Of methodological importance is the opportunity to correlate complementary cortical mapping techniques. Clinical implications include elucidating the relationship between temporal lobe representations of complex sound processing and individual auditory processing abilities.

描述：（由申请人提供）：本研究的长期目标是了解人类外侧颞叶复杂声音处理的组织。我们将重点关注复杂调频 (FM) 声音（包括语音）的颞叶处理。区分频率变化速率和方向不同的 FM 声音的能力是许多听觉行为（包括语音感知）不可或缺的一部分。 推动这项研究的主要假设是外侧颞叶内的一个子系统专门用于区分复杂的 FM 声音。进一步假设功能专业化的缺乏与听觉处理异常有关。我们将通过将功能性损伤（皮质刺激）和神经生理学（皮质电图）方法与听觉辨别范例相结合来测试这些假设，以研究出于临床目的硬膜下植入电极的癫痫患者。初步研究证实了所提出方法的可行性。具体目标是：1）描绘对于复杂的FM声音辨别至关重要的外侧颞叶区域； 2) 量化正常和异常中枢听觉系统中复杂 FM 声音辨别的颞叶表征的变异性； 3) 识别皮质电图反应的空间和时间特征，这些特征表明复杂的 FM 声音处理的专业化。 这项研究的意义包括更好地了解外侧颞叶系统的功能组织以及变异性的相关影响。具有方法论重要性的是关联互补皮质绘图技术的机会。临床意义包括阐明复杂声音处理的颞叶表征与个体听觉处理能力之间的关系。