Variability in Cortical Auditory Event-Related Responses

皮质听觉事件相关反应的变异性

• 批准号: 7861145
• 负责人: Dana F. Boatman
• 金额: $ 1.86万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7861145
• 关键词: Address; Agreement; Audiology; Auditory; Auditory Perceptual Disorders; Auditory area; Auditory system; Biomedical Engineering; Biometry; Classification; Clinical; Clinical Research; Communication; Complement; Complex; Data; Electrodes; Electroencephalography; Epilepsy; Etiology; Evaluation; Event; Fourier Transform; Frequencies; Functional disorder; Funding; Goals; Hearing; Human; Implanted Electrodes; Intractable Epilepsy; Language; Maps; Measurement; Measures; Mentors; Methods; Modeling; Neurology; Operative Surgical Procedures; Participant; Patients; Pattern; Postdoctoral Fellow; Procedures; Process; Regression Analysis; Research; Research Training; Resolution; Seizures; Signal Transduction; Site; Spatial Distribution; Specificity; Statistical Models; Stimulus; Students; Testing; Time; auditory stimulus; base; behavior test; computerized data processing; design; experience; improved; indexing; insight; neurophysiology; pre-doctoral; relating to nervous system; remediation; response; skills; sound; transmission process

DESCRIPTION (provided by applicant): The overall project goal is to understand variability in the functional organization of human auditory cortex. We will focus on within-subject variability in cortical auditory event-related responses (evoked, induced) of normal and impaired listeners. Participants are normal-hearing patients with medically intractable epilepsy who have subdural electrodes implanted for clinical purposes. Patients are identified as normal or impaired listeners based on behavioral tests of auditory processing. We hypothesize that patients with normal auditory processing abilities show stimulus-specific effects and low test-retest variability in cortical auditory event-related responses, while patients who are impaired listeners demonstrate reduced stimulus specificity and high test-retest variability. A repeated-measures design will be used to address three specific aims. Intracranial recordings will be obtained using simple and complex auditory stimuli. Preliminary studies have confirmed the feasibility of the methods proposed. Candidate: Dr. Boatman is an audiologist and clinical neurophysiologist with 12 years of clinical research experience using electrophysiological methods to investigate normal and impaired cortical auditory function. The intracranial auditory recording studies proposed complement the candidate's R01-funded electrocortical stimulation mapping research and will provide opportunities for additional training and research mentoring in signal processing and statistical modeling of multi-channel intracranial EEG data. Research: We will address three aims: 1) identify stimulus-related differences in cortical auditory responses; 2) determine test-retest reliability; and 3) quantify within-subject variability by listening ability (normal, impaired). Single channel time-domain and time-frequency analyses will be used, with regression models, to quantify within-subject differences in early and late cortical evoked responses and induced spectral power changes. Multi-channel time-frequency analysis will be used to investigate functional connectivity. Mentoring: Research mentoring activities will include research training for pre-doctoral and post-doctoral trainees from the clinical fields of audiology and neurology (epilepsy, clinical neurophysiology), and cross- disciplinary clinical research training for pre-doctoral students in biostatistics and biomedical engineering. RELEVANCE: Understanding variability in cortical auditory event-related responses has clinical implications for improved measurement accuracy and objective assessment of cortical auditory function. By studying within-subject variability in the cortical auditory event-related response patterns of epilepsy patients with subdural electrodes, we hope to provide new insights into the neural bases of auditory processing disorders common in epilepsy and to provide a framework for evaluating remediation therapies.

描述（由申请人提供）：总体项目目标是了解人类听觉皮层功能组织的变异性。我们将重点介绍正常听众和受损的听众的皮质听觉事件相关响应（诱发，诱导）的受试者内变异性。参与者是患有医学上顽固性癫痫病的正常患者，这些患者的硬膜下电极植入了临床目的。根据听觉处理的行为测试，将患者识别为正常或受损的听众。我们假设具有正常听觉处理能力的患者在皮质听觉事件相关的反应中表现出刺激特异性效应和低测试可变性，而受损的听众的患者表现出刺激特异性降低和高测试重度可变性。重复测量设计将用于解决三个特定目标。颅内记录将使用简单且复杂的听觉刺激获得。初步研究证实了提出的方法的可行性。 候选人：Boatman博士是使用电生理方法研究正常和受损的皮质听觉功能的12年临床研究经验的听觉学家和临床神经生理学家。颅内听觉记录研究提出了补充候选人的R01资助的电皮质刺激图研究，并将为信号处理和多渠道内脑内脑电图数据的信号处理和统计模型进行额外培训和研究提供机会。 研究：我们将解决三个目标：1）确定皮质听觉反应中与刺激相关的差异； 2）确定重测的可靠性； 3）通过听力能力（正常，受损）量化受试者内部的变异性。将使用单个通道时域和时频分析，与回归模型一起量化皮质诱发响应和诱导光谱功率变化的受试者内部差异。多通道时频分析将用于研究功能连接性。指导：研究指导活动将包括来自听力学和神经病学临床和神经病学临床领域（癫痫，临床神经生理学）的研究前和博士后学员的研究培训，以及生物统计学和生物培训工程学的杂志前学生的跨学科临床研究培训。 相关性：了解皮质听觉事件相关响应的变异性具有提高测量准确性和对皮质听觉功能的客观评估的临床意义。通过研究皮质听觉事件与硬膜下电极癫痫患者的皮质听觉事件反应模式的受试者内变异性，我们希望为癫痫病常见的听觉加工障碍的神经碱提供新的见解，并为评估修复疗法提供框架。