Variability in Cortical Auditory Event-Related Responses

皮质听觉事件相关反应的变异性

• 批准号: 7861145
• 负责人: Dana F. Boatman
• 金额: $ 1.86万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7861145
• 关键词: Address; Agreement; Audiology; Auditory; Auditory Perceptual Disorders; Auditory area; Auditory system; Biomedical Engineering; Biometry; Classification; Clinical; Clinical Research; Communication; Complement; Complex; Data; Electrodes; Electroencephalography; Epilepsy; Etiology; Evaluation; Event; Fourier Transform; Frequencies; Functional disorder; Funding; Goals; Hearing; Human; Implanted Electrodes; Intractable Epilepsy; Language; Maps; Measurement; Measures; Mentors; Methods; Modeling; Neurology; Operative Surgical Procedures; Participant; Patients; Pattern; Postdoctoral Fellow; Procedures; Process; Regression Analysis; Research; Research Training; Resolution; Seizures; Signal Transduction; Site; Spatial Distribution; Specificity; Statistical Models; Stimulus; Students; Testing; Time; auditory stimulus; base; behavior test; computerized data processing; design; experience; improved; indexing; insight; neurophysiology; pre-doctoral; relating to nervous system; remediation; response; skills; sound; transmission process

DESCRIPTION (provided by applicant): The overall project goal is to understand variability in the functional organization of human auditory cortex. We will focus on within-subject variability in cortical auditory event-related responses (evoked, induced) of normal and impaired listeners. Participants are normal-hearing patients with medically intractable epilepsy who have subdural electrodes implanted for clinical purposes. Patients are identified as normal or impaired listeners based on behavioral tests of auditory processing. We hypothesize that patients with normal auditory processing abilities show stimulus-specific effects and low test-retest variability in cortical auditory event-related responses, while patients who are impaired listeners demonstrate reduced stimulus specificity and high test-retest variability. A repeated-measures design will be used to address three specific aims. Intracranial recordings will be obtained using simple and complex auditory stimuli. Preliminary studies have confirmed the feasibility of the methods proposed. Candidate: Dr. Boatman is an audiologist and clinical neurophysiologist with 12 years of clinical research experience using electrophysiological methods to investigate normal and impaired cortical auditory function. The intracranial auditory recording studies proposed complement the candidate's R01-funded electrocortical stimulation mapping research and will provide opportunities for additional training and research mentoring in signal processing and statistical modeling of multi-channel intracranial EEG data. Research: We will address three aims: 1) identify stimulus-related differences in cortical auditory responses; 2) determine test-retest reliability; and 3) quantify within-subject variability by listening ability (normal, impaired). Single channel time-domain and time-frequency analyses will be used, with regression models, to quantify within-subject differences in early and late cortical evoked responses and induced spectral power changes. Multi-channel time-frequency analysis will be used to investigate functional connectivity. Mentoring: Research mentoring activities will include research training for pre-doctoral and post-doctoral trainees from the clinical fields of audiology and neurology (epilepsy, clinical neurophysiology), and cross- disciplinary clinical research training for pre-doctoral students in biostatistics and biomedical engineering. RELEVANCE: Understanding variability in cortical auditory event-related responses has clinical implications for improved measurement accuracy and objective assessment of cortical auditory function. By studying within-subject variability in the cortical auditory event-related response patterns of epilepsy patients with subdural electrodes, we hope to provide new insights into the neural bases of auditory processing disorders common in epilepsy and to provide a framework for evaluating remediation therapies.

描述（由申请人提供）：总体项目目标是了解人类听觉皮层功能组织的变异性。我们将重点关注正常和受损听众的皮层听觉事件相关反应（诱发、诱导）的受试者内部变异性。参与者是患有难治性癫痫的听力正常的患者，他们出于临床目的植入了硬膜下电极。根据听觉处理的行为测试，将患者识别为正常或受损的听众。我们假设具有正常听觉处理能力的患者在皮质听觉事件相关反应中表现出刺激特异性效应和低重测变异性，而听力受损的患者表现出刺激特异性降低和高重测变异性。重复措施设计将用于实现三个具体目标。将使用简单和复杂的听觉刺激来获得颅内录音。初步研究证实了所提出方法的可行性。 候选人：Boatman 博士是一位听力学家和临床神经生理学家，拥有 12 年使用电生理学方法研究正常和受损的皮质听觉功能的临床研究经验。拟议的颅内听觉记录研究补充了候选人 R01 资助的皮层电刺激映射研究，并将为多通道颅内脑电图数据的信号处理和统计建模提供额外的培训和研究指导机会。 研究：我们将实现三个目标：1）识别皮质听觉反应中与刺激相关的差异； 2) 确定重测可靠性； 3) 通过听力能力（正常、受损）量化受试者内部的变异性。将使用单通道时域和时频分析以及回归模型来量化早期和晚期皮质诱发反应和诱发光谱功率变化的受试者内差异。多通道时频分析将用于研究功能连接性。指导：研究指导活动将包括对听力学和神经病学（癫痫、临床神经生理学）临床领域的博士前和博士后学员进行研究培训，以及对生物统计学和生物医学工程博士前学生进行跨学科临床研究培训。 相关性：了解皮质听觉事件相关反应的变异性对于提高皮质听觉功能的测量准确性和客观评估具有临床意义。通过使用硬膜下电极研究癫痫患者皮质听觉事件相关反应模式的受试者内变异性，我们希望为癫痫常见听觉处理障碍的神经基础提供新的见解，并为评估治疗疗法提供一个框架。