Complex Sound Processing in the Human Temporal Lobe

人类颞叶的复杂声音处理

• 批准号: 6603815
• 负责人: Dana F. Boatman
• 金额: $ 26.04万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6603815
• 关键词: auditory discrimination; auditory stimulus; behavioral /social science research tag; brain mapping; clinical research; direct cortical response; electrocorticography; epilepsy; human subject; neural information processing; sound frequency; sound perception; speech; speech recognition; stimulus /response; temporal lobe /cortex

DESCRIPTION: (provided by applicant): The long-term goal of this research is to understand the organization of complex sound processing in the human lateral temporal lobe. We will focus on temporal lobe processing of complex frequency-modulated (FM) sounds, including speech. The ability to discriminate FM sounds that differ in rate and direction of frequency change is integral to many auditory behaviors, including speech perception. The main hypothesis motivating this research is that a subsystem within the lateral temporal lobe is specialized for discriminating complex FM sounds. It is further hypothesized that absence of functional specialization is associated with auditory processing abnormalities. We will test these hypotheses by combining functional lesion (cortical stimulation) and neurophysiologic (electrocorticography) methods with an auditory discrimination paradigm, to study seizure patients with electrodes implanted subdurally for clinical purposes. Preliminary studies have confirmed the feasibility of the methodologies proposed.The specific aims are to: 1) delineate lateral temporal lobe regions that are critical for complex FM sound discrimination; 2) quantify variability in the temporal lobe representations of complex FM sound discrimination in normal and abnormal central auditory systems; and 3) identify spatial and temporal features of electrocorticographic responses that suggest specialization for complex FM sound processing. The significance of this research includes a better understanding of the functional organization of the lateral temporal lobe system and the associated effects of variability. Of methodological importance is the opportunity to correlate complementary cortical mapping techniques. Clinical implications include elucidating the relationship between temporal lobe representations of complex sound processing and individual auditory processing abilities.

描述：（由申请人提供）：这项研究的长期目标是了解人侧颞叶中复杂的声音处理的组织。我们将重点介绍复杂频率调节（FM）声音的颞叶处理，包括语音。区分频率变化率和方向不同的FM声音的能力对于许多听觉行为（包括语音感知）是不可或缺的。 促使这项研究的主要假设是，横向颞叶中的一个子系统专门用于区分复杂的FM声音。进一步假设缺乏功能专业与听觉处理异常有关。我们将通过结合功能病变（皮质刺激）和神经生理学（电皮质摄影）方法与听觉歧视范式结合使用功能性病变（皮质刺激）和神经生理学（电皮质造影）方法来检验这些假设，以在临床目的下植入电极植入电极。初步研究已经证实了提出的方法的可行性。具体目的是：1）描绘对复杂的FM声音歧视至关重要的横向颞叶区域； 2）量化正常和异常中央听觉系统中复杂FM声音歧视的颞叶表示的可变性； 3）确定电视学响应的空间和时间特征，这些响应建议专门用于复杂的FM声音处理。 这项研究的意义包括更好地了解横向颞叶系统的功能组织以及可变性的相关影响。方法论上的重要性是将互补皮质映射技术相关联的机会。临床意义包括阐明复杂声音处理的颞叶表示与单个听觉处理能力之间的关系。