Neuropsychology of primate social cognition

灵长类社会认知的神经心理学

• 批准号: 6780329
• 负责人: LISA A. PARR
• 金额: $ 22.5万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6780329
• 关键词: Macaca mulatta; Pan; auditory stimulus; behavior test; behavioral /social science research tag; brain imaging /visualization /scanning; brain metabolism; computers; cues; deoxyglucose; emotions; face; face expression; family; glucose metabolism; neural information processing; neuropsychology; positron emission tomography; social perception; space perception; speech recognition; videotape /videodisc; visual perception; visual stimulus

DESCRIPTION (provided by applicant): This proposal aims to identify neuropsychological processes associated with social cognition in primates through a comprehensive comparison of the cognitive, behavioral and neuroanaomical substrates underlying face recognition and emotional processing, in two species closely related to humans, chimpanzees and rhesus monkeys. Providing a detailed comparison of cognitive and emotional processes in rhesus and chimpanzees will serve the long-term objective of helping to identify the best species to model some aspects of human behavior. These questions are critically important because of the numerous psychiatric, neurodegenerative, and developmental disorders present in humans that share face recognition and emotional processing impairments as part of their primary phenotype. Some aspects of face recognition and garnering emotional information from facial expressions are impaired in individuals with autism, schizophrenia, psychopathy, prosopagnosia, Fragile X, Alzheimer's, William's syndrome, major depression, and various forms of dementia. This project proposes five specific aims. Specific Aim 1 will examine what features monkeys and apes use to discriminate faces, including eye gaze, spatial orientation, facial features, and individual familiarity. Specific Aims 2 and 3 will examine the role of auditory and visual cues in individual recognition and the categorization of facial expressions. Specific Aim 4 will examine the ability of monkeys and apes to recognize kin relationships using the faces of unfamiliar individuals, and whether the heritability of physiognomic characteristics differers with maternal or paternal influences. Finally, integrating several of these questions is Specific Aim 5 that will compare patterns of regional cerebral glucose metabolism during face and facial expression processing using 18F-FDG positron emission tomography. The proposed studies go beyond previous studies on nonhuman primates in that they aim to compare social cognition processes in two different primate species that vary in their social organization, genetic similarity to humans, and cognitive abilities. Moreover, by using similar training and testing methodologies our work will extend these cognitive findings to comparisons of the patterns of neural specificity using functional neuroimaging.

描述（由申请人提供）：该提案旨在通过对认知，行为和神经疾病的底物进行全面比较，以确定与灵长类动物在灵长类动物中的社会认知相关的神经心理学过程，这两个物种与人类，黑猩猩和瑞典猴子密切相关。在恒河馆和黑猩猩中提供认知和情感过程的详细比较将有助于确定最佳物种以建模人类行为的某些方面的长期目标。这些问题至关重要，因为在人类中存在许多精神病，神经退行性和发育障碍，它们作为其主要表型的一部分共享面部识别和情感处理障碍。自闭症，精神分裂症，精神病，prosopagnosia，脆弱的X，Alzheimer's，William's综合征，重大抑郁症和各种形式的痴呆症患者，面部识别和从面部表情中获得情感信息的某些方面受到了损害。该项目提出了五个具体目标。特定目标1将检查猴子和猿类用来区分面部面孔的特征，包括眼睛凝视，空间取向，面部特征和个人熟悉。具体目的2和3将研究听觉和视觉线索在个人识别以及面部表情分类中的作用。特定的目标4将检查猴子和猿类使用陌生个体的面孔识别亲属关系的能力，以及与母体或父亲影响不同的身体特征的遗传力是否不同。最后，将其中几个问题整合为特定的目标5，它将比较使用18F-FDG正电子发射断层扫描过程中面部和面部表达处理过程中区域脑葡萄糖代谢的模式。拟议的研究超出了对非人类灵长类动物的先前研究，因为它们旨在比较两个不同的灵长类动物中的社会认知过程，这些灵长类动物在其社会组织中有所不同，与人类的遗传相似性以及认知能力。此外，通过使用类似的训练和测试方法，我们的工作将这些认知发现扩展到使用功能神经影像学的神经特异性模式的比较。