Using MaqFACS to measure facial movement deficits in monkeys

使用 MaqFACS 测量猴子的面部运动缺陷

• 批准号: 8317537
• 负责人: LISA A. PARR
• 金额: $ 22万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8317537
• 关键词: Adult; Affect; Animal Model; Antiparkinson Agents; Award; Behavior; Behavioral; Belief; Bradykinesia; Certification; Chronic; Clinical; Code; Corpus striatum structure; Data; Development; Disease; Dopamine Agonists; Dose; Effectiveness; Emotional; Ensure; Exposure to; Face; Facial Expression; Facial Muscles; Functional disorder; Funding; Goals; Gold; Human; Hypokinesia; Impairment; Individual; Laboratories; Macaca mulatta; Manuals; Masks; Measurement; Measures; Mental disorders; Methods; Modeling; Monitor; Monkeys; Motor; Movement; Movement Disorders; Neurodegenerative Disorders; Parkinson Disease; Parkinsonian Disorders; Posture; Primates; Procedures; Publishing; Recovery of Function; Research; Research Personnel; Services; Severities; Study models; Symptoms; System; Testing; Training; Tremor; United States National Institutes of Health; Video Recording; base; behavior rating scale; cost; dopaminergic neuron; early onset; effective therapy; interdisciplinary collaboration; interest; movie; pramipexol; response; social; standard measure; tool

DESCRIPTION (provided by applicant): Parkinson's Disease (PD) is a progressive neurodegenerative disorder caused by a depletion of dopamine (DA) neurons in the striatum. Its major symptoms are movement- related, including tremors, bradykinesis, stooped posture, and masked facial affect. There are several monkey models for studying the pathophysiology of PD. The most widely used involves a MPTP, a substance that is toxic to dopaminergic neurons and very accurately mirrors the underlying cause, symptoms and progression of PD in humans. To assess the motor-related impairments in MPTP monkeys, researchers have adapted traditional clinical rating systems, but until recently, no standardized measurement system has been available to assess deficits in facial expressivity, despite this being a debilitating symptom of PD in humans. The FACS (Facial Action Coding System) is the gold standard for measuring facial movement in humans. FACS is anatomically-based as it identifies facial movement according to the underlying action of facial muscles. Researchers have used FACS to reveal deficits in both the type and intensity of facial expressions made by people with PD. Investigators have recently developed a monkey FACS (MaqFACS) and pilot data in MPTP monkeys suggest that this system may be a more sensitive measure of early onset PD than traditional rating systems. This project will directly assess the effectiveness of MaqFACS, compared to other rating systems (activity monitoring and a behavioral rating scale), in characterizing the progression of PD symptoms in MPTP-treated monkeys. Facial movement will be video recorded and then coded using MaqFACS during baseline sessions as well as two emotional provocations (exposure to a mirror and response to movies of other monkeys) to evoke facial expressivity. Inter-individual variability in facial movement will be quantified and changes in the type and amount of facial movement will be compared across the MPTP-treatment progression. The PD monkeys will then be given a DA agonist to reverse their symptoms and recovery of function will be assessed using the same testing and measurement procedures. These data will validate the effectiveness of MaqFACS in identifying the early onset of PD symptoms in the most common monkey model of PD and aid in the development of effective treatments.

描述（由申请人提供）：帕金森氏病（PD）是纹状体中多巴胺（DA）神经元耗竭引起的进行性神经退行性疾病。它的主要症状与运动有关，包括震颤，弯曲，弯曲的姿势和面部遮罩。有几种研究PD的病理生理学的猴子模型。使用最广泛的涉及MPTP，MPTP是一种对多巴胺能神经元有毒的物质，并且非常准确地反映了人类PD的根本原因，症状和进展。为了评估MPTP猴子中与运动相关的障碍，研究人员已经适应了传统的临床评级系统，但是直到最近，尽管这是人类PD的衰减症状，但仍未使用标准化的测量系统来评估面部表现性的缺陷。 FACS（面部动作编码系统）是测量人类面部运动的黄金标准。 FACS是基于解剖的，因为它根据面部肌肉的潜在作用来识别面部运动。研究人员已经使用FACS揭示了PD患者的面部表情类型和强度的缺陷。研究人员最近开发了一个猴子FACS（MAQFAC），而MPTP猴子中的试验数据表明，该系统可能比传统评级系统更敏感地衡量早期发作PD。与其他评级系统（活动监测和行为评级量表）相比，该项目将直接评估MAQFAC的有效性，以表征经MPTP处理的猴子中PD症状的进展。面部运动将在基线会话期间进行视频录制，然后使用Maqfacs进行录制，并使用MAQFAC进行编码，并进行两种情感挑衅（暴露于镜子和对其他猴子的电影的反应），以唤起面部表情。面部运动的个体间变异性将被量化，并在MPTP处理的进展中比较面部运动的类型和数量的变化。然后，将使用相同的测试和测量程序来评估PD猴子以扭转其症状，以扭转功能的症状，并恢复功能。这些数据将验证MAQFAC在最常见的PD模型中识别PD症状早期发作的有效性，并有助于开发有效治疗。