Training in translational social neuroscience

转化社会神经科学培训

• 批准号: 8509788
• 负责人: LISA A. PARR
• 金额: $ 9.82万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8509788
• 关键词: Adult; Affect; Age-Months; Aggressive behavior; Animal Model; Animals; Antipsychotic Agents; Area; Attention; Autistic Disorder; Award; Basic Science; Behavior; Behavior Therapy; Behavioral; Blood - brain barrier anatomy; Centers for Disease Control and Prevention (U.S.); Child; Clinical; Clinical Research; Cognitive; Collaborations; Data; Development; Diagnosis; Discrimination; Disease; Dose; Drug Compounding; Early Diagnosis; Early Intervention; Emotions; Empathy; Environment; Explosion; Eye; Face; Facial Expression; Facial Expression Recognition; Funding; Goals; Health; Human; Image; Impairment; Incidence; Individual; Infant; K-Series Research Career Programs; Knowledge; Laboratories; Lead; Learning; Macaca mulatta; Memory; Mental disorders; Methodology; Methods; Modeling; Monkeys; Neuraxis; Neurobiology; Neurodevelopmental Disorder; Neurologic; Neuropeptides; Neuropharmacology; Neurosciences; Outcome; Oxytocin; Performance; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacotherapy; Phenotype; Physician Executives; Pongidae; Preclinical Drug Evaluation; Primates; Procedures; Process; Reading; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Training; Risk; Risk Factors; Risperidone; Rodent; Role; Safety; Self-Injurious Behavior; Social Behavior; Social Discrimination; Social Interaction; Social Perception; Solid; Symptoms; System; Testing; Time; Training; Translational Research; Trust; Universities; Validation; Vasopressins; Visual; Work; autism spectrum disorder; base; career development; comparative; cost; design; experience; face perception; improved; information processing; interest; intervention program; nonhuman primate; novel; pre-clinical; preclinical study; preference; programs; research study; skills; social; social cognition; social neuroscience

DESCRIPTION (provided by applicant): Candidate: I have had a competitive, independent research program at the Yerkes National Primate Center and Emory University for over 10 years focusing on comparative social cognition, specifically how monkeys and apes process information about identity and emotion from faces. Face recognition is an important skill in humans and its deficits are a common phenotype in numerous neurodevelopmental and neuropathological disorders, like autism. Because of this, I have become interested in exploring the possibility for translational applications for this research, bridging basic research in monkey with preclinical studies. With the newly formed Center for Translational Social Neuroscience at Emory and the recruitment of Dr. Ami Klin to serve as Director for Autism Research at the Marcus Autism Center in Atlanta, I feel that this is the ideal time to seek new training that will advance my opportunities for career development in translational social neuroscience and autism research. Therefore, this Career Development Award is designed to broaden my solid background in basic research on social cognition by providing training in translational social neuroscience focused on clinical research training in autism and training in the neuropharmacology of prosocial behavior. Environment: Training will be achieved through collaboration with colleagues at Emory University, the Yerkes National Primate Research Center, the Center for Translational Social Neuroscience at Emory, and the Marcus Autism Center. Each of these Centers is located within a mile of Emory's main campus, is world renowned for scientific and academic excellence, and will provide unparalleled support both in terms of infrastructure and opportunities for career development. The short-term goals for this award are threefold. The first goal is to gain important training in neuropeptide systems and basic neuropharmacology research methods. This will come through interactions with Dr. Larry Young, Director for the Center for Translational Social Neuroscience and Division of Behavioral Neuroscience and Psychiatric Disorders. This will include training in how to determine drug doses and delivery methods for administering oxytocin to primates. I will apply this knowledge to investigate whether the neuropeptide oxytocin can modulate monkeys' performance on social cognitive tasks. Additionally, I will work with Dr. Leonard Howell, Director for the Division of Neuropharmacology and Neurologic Diseases and the Yerkes Imaging Center to learn several basic neurosurgical preparations and drug administration procedures that are commonly used to study the neuropharmacological basis of behavior in monkeys. The second goal is to gain clinical experience using translational research methods in autism. To do this, I will work with Dr. Ami Klin, the Director for Autism Research at the Marcus Autism Center. Dr. Klin's laboratory has pioneered the use of robust, data-driven eye- tracking methods for studying visual social engagement in autism. Using these methods, Dr. Klin and his team have identified risk factors for developing autism in infants as early as 6 months of age. I will then implement these methods to study visual social engagement in monkeys, providing a hands-on opportunity to apply this translational research approach to my currently funded studies. The final goal is to gain clinical training in autism through interactions with both Dr. Roy Sanders, Medical Director at Marcus, and Dr. Klin by observing children with ASD, learning about early intervention programs, and assisting with research studies. Research: The proposed research builds strategically on my expertise in comparative social cognition while providing the opportunity for the hands-on training in these new areas. The training Aim 1 will investigate whether oxytocin is able to influence the performance of monkeys on several of the current R01 tasks (Aims 1, 2 and 4), including face recognition, facial expression discrimination and social attention. The training Aim 2 is to apply the objective, data-driven eye-tracking methods used to study visual social engagement in infants at risk for developing autism to studies of monkey social perception. This will strengthen the approach to be taken in the current R01 Aim 1, which is to use eye-tracking to compare the validity of viewing preference compared to operant procedures in studies of primate social cognition, as it will establish this translational method as viable in monkeys. My long-term goal is to develop a competitive research program that bridges comparative and translational social neuroscience to understand the basic behavior and neurobiology of social cognition, with a focus on developing animal models for the treatment of social deficits. The new aims proposed in this award will provide hands-on opportunities to apply the new training in a manner that will not only enhance the outcome of my current R01, but provide the experience necessary to achieve my long-term goals for career development.

描述（由申请人提供）：候选人：我在Yerkes国家灵长类动物中心和埃默里大学（Emory University）有一项竞争性，独立的研究计划已有10多年了，重点关注比较社会认知，特别是猴子和猿类如何处理有关面部身份和情感的信息。面部识别是人类的重要技能，其缺陷是许多神经发育和神经病理学疾病（如自闭症）中的常见表型。因此，我对探索这项研究的翻译应用可能性感兴趣，并通过临床前研究将基础研究桥接。随着新成立的埃默里转化社会神经科学中心和Ami Klin博士的招募，担任亚特兰大Marcus自闭症中心的自闭症研究主管，我认为这是寻求新培训的理想时机，可以促进我在翻译社会神经科学和自闭症研究中的职业发展机会。因此，该职业发展奖旨在通过提供转化社会神经科学的培训来扩大我在社会认知基础研究方面的扎实背景，该培训的重点是自闭症和亲社会行为神经药理学的临床研究培训。环境：通过与埃默里大学，耶克斯国家灵长类动物研究中心，埃默里转化社会神经科学中心和马库斯自闭症中心的同事合作来实现培训。这些中心中的每个中心都位于埃默里（Emory）主校园一英里范围内，世界以科学和学术在卓越的状态而闻名，并将在基础设施和职业发展机会方面提供无与伦比的支持。该奖项的短期目标是三倍。第一个目标是在神经肽系统和基本神经药理学研究方法中获得重要的培训。这将通过与转化社会神经科学中心和行为神经科学和精神疾病的划分的主任拉里·杨（Larry Young）博士进行互动。这将包括如何确定对催产素给灵长类动物施用的药物剂量和输送方法的培训。我将应用这些知识来研究神经肽催产素是否可以调节猴子在社会认知任务上的表现。此外，我将与神经药理学和神经系统疾病和Yerkes成像中心主任伦纳德·豪威尔博士合作学习几种基本的神经外科准备和药物管理程序，这些程序通常用于研究猴子行为的神经病理学基础。第二个目标是使用自闭症中的翻译研究方法获得临床经验。为此，我将与Marcus自闭症中心自闭症研究主管Ami Klin博士合作。 Klin博士的实验室率先使用了强大的，数据驱动的眼神跟踪方法来研究自闭症的视觉社交参与。使用这些方法，Klin博士和他的团队最早在6个月大时就确定了在婴儿中发展自闭症的风险因素。然后，我将实施这些方法来研究猴子中的视觉社会参与，从而提供了一个动手的机会，将这种翻译研究方法应用于我当前资助的研究。最终的目标是通过与Marcus医学主任Roy Sanders博士和Klin博士进行互动，通过观察ASD的儿童，学习早期干预计划以及协助研究研究来获得自闭症的临床培训。研究：拟议的研究从战略性地基于我在比较社会认知方面的专业知识，同时为这些新领域的动手培训提供了机会。培训目标1将研究催产素是否能够影响猴子在当前的几个R01任务上的表现（目标1、2和4），包括面部识别，面部表情歧视和社会关注。培训目标2是应用目标，数据驱动的眼球追踪方法，用于研究患有自闭症风险的婴儿的视觉社交参与，以研究猴子社会知觉的研究。这将加强当前R01 AIM 1中要采取的方法，即在灵长类动物社会认知研究中，与操作程序相比，使用眼睛跟踪来比较观看偏好的有效性，因为它将确定这种翻译方法在可行的情况下可行 猴子。我的长期目标是制定一项竞争性研究计划，该计划桥接比较和转化的社会神经科学，以了解社会认知的基本行为和神经生物学，重点是开发动物模型来治疗社会缺陷。该奖项中提出的新目标将提供动手实践的机会，以一种不仅可以增强我当前R01的结果的方式应用新培训，而且还提供了实现我实现职业发展的长期目标所必需的经验。