The effect of Oxytocin on Social Perception and Social Reward

催产素对社会感知和社会奖励的影响

• 批准号: 8883719
• 负责人: LISA A. PARR
• 金额: $ 37.23万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8883719
• 关键词: Address; Adult; Advanced Development; Affect; Animal Model; Animals; Attention; Attenuated; Autistic Disorder; Behavior; Behavioral; Blood - brain barrier anatomy; Brain; Cerebrospinal Fluid; Cognitive; Complex; Data; Detection; Development; Disease; Emotions; Ensure; Evaluation; Eye; Face; Facial Expression; Feedback; Goals; Health; Hormones; Human; Impairment; Individual; Injection of therapeutic agent; Instruction; Investigation; Knowledge; Macaca mulatta; Measures; Monkeys; Neuraxis; Neurobiology; Neuromodulator; Neuropeptides; Outcome; Oxytocin; Oxytocin Receptor; Perception; Performance; Peripheral; Pharmacotherapy; Pre-Clinical Model; Primates; Qualifying; Reading; Research; Research Personnel; Rewards; Rodent; Safety; Seminal; Social Behavior; Social Interaction; Social Perception; Stimulus; System; Techniques; Testing; Vasopressins; Visual; Visual attention; behavioral outcome; cognitive task; design; directed attention; drug development; emotional stimulus; improved; joint attention; neuropsychiatry; nonhuman primate; novel; pre-clinical; screening; social; social attention; social cognition; social skills

PROJECT SUMMARY (See instructions): Oxytocin (OT) functions as a neuromodulator in the central nervous system (CNS) to promote social behavior and affiliation in animals and. Because of its prosocial effects, researchers have begun to explore whether OT could be used as a novel pharmacotherapy to treat a variety of neuropsychiatric disorders characterized by social impairments, such as autism. Indeed, several studies have now emerged suggesting that intranasally administered (IN) OT can improve prosocial behavior in adults with high-functioning autism, including cooperation, reading facial expressions, and directing attention to the eye region in faces . However, the exact mechanisms by which IN-OT influence prosocial behavior in primates remain unclear, including whether OT acts centrally in the brain through the oxytocin receptor system (OXTR) or through peripheral feedback. Therefore, while OT is an extremely attractive potentials pharmacotherapy that could function to ameliorate social impairments and enhance prosocial behavior in humans, many questions remain about its mechanism of action and overall function. This is particularly true in nonhuman primates. Although they represent an ideal preclinical model for screening the behavioral and neurobiological effects of OT, only a handful of studies investigated the effect of OT on nonhuman primate social cognition. It is the goal of this study to compare the effect of IN-OT and intracerebroventricular (ICV) OT, and an OXTR-antagonist on tasks that address social perception social reward in rhesus monkeys. The tasks used are designed to mirror those used in studies of IN-OT in humans, and address some ofthe same social skills known to be impaired in autism, e.g., salience of social stimuli, social reward, recognition of familiar faces, and emotion categorization. Additionally, monkeys will be shown complex videos of familiar and unfamiliar monkeys engaged in social interactions during eye-tracking to determine how IN-OT affects the convergence of social attention. This project will provide seminal data on how OT affects social perception and social reward and contribute to it pharmacotherapeutic development.

项目摘要（请参阅说明）：催产素（OT）在中枢神经系统（CNS）中充当神经调节剂，以促进动物的社会行为和隶属关系。由于其亲社会影响，研究人员已经开始探索OT是否可以用作新型药物治疗，以治疗以社会障碍（例如自闭症）为特征的各种神经精神疾病。实际上，现在已经出现了一些研究，表明鼻内给药（OT）可以改善具有高功能自闭症的成年人的亲社会行为，包括合作，阅读面部表情以及将注意力转移到脸上的眼睛区域。但是，IT-OT影响灵长类动物的亲社会行为的确切机制尚不清楚，包括OT是通过催产素受体系统（OXTR）还是通过周围反馈在大脑中集中作用。因此，尽管OT是一种极具吸引力的药物疗法，可以改善社会障碍并增强人类的亲社会行为，但有关其作用机理和整体功能的许多问题仍然存在。在非人类灵长类动物中尤其如此。尽管它们代表了筛选OT行为和神经生物学效应的理想临床前模型，但只有少数研究研究了OT对非人类灵长类动物社会认知的影响。本研究的目的是比较脑室内和脑室内（ICV）OT的影响，以及对解决恒河猴猴子社会认知社会奖励的任务的oxtr-antagonist。所使用的任务旨在反映在人类IN-OT研究中使用的任务，并解决了自闭症中已知的一些社交技能，例如，社交刺激的显着性，社会奖励，对熟悉的面孔的认可和情感分类。此外，将向猴子展示猴子的复杂视频，展示熟悉和陌生的猴子在眼球追踪期间从事社交互动的视频，以确定IN-OT如何影响社会关注的融合。该项目将提供有关OT如何影响社会看法和社会奖励的开创性数据，并为IT药物治疗发展做出贡献。