Corneal Refractive Power Post Refractive Surgery

屈光手术后的角膜屈光力

• 批准号: 6806743
• 负责人: CHARLOTTE E JOSLIN
• 金额: $ 16.49万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-06 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6806743
• 关键词: cataract surgery; clinical research; cornea; eye surgery; human subject; intraocular fluid; mathematical model; model design /development; patient oriented research; refractive keratoplasty; statistics /biometry

DESCRIPTION (provided by applicant): The primary goal of this proposal is to train the applicant as a health professional to become an independent investigator. To achieve this goal, a five-year, mentored training program with heavy didactic coursework in epidemology and biostatistics is described that will lead to a PhD in epidemiology. Six mentors, with expertise in epidemiology, biostatistics, clinical research, cataract and refractive surgery, and theoretical opticas have been selected. The secondary goal of this proposal is to investigate the current inaccuracies of corneal power estimation and intraocular lens (IOL) power calculation in eyes that have undergone myopic refractive surgery and require cataract extraction and IOL placement. Current methods used to calculate IOL power in non-surgical eyes are inaccurate post-refractive surgery and cause unintentional hyperopia in up to 83-100% of eyes post-cataract surgery. Historical clinical data, the "gold standard" in estimating corneal power post-refractive surgery is rarely available, especially decades later when cataract surgery is necessary. We propose to: a) identify a theoretical model using a cross-sectional study that will allow us to evaluate and refine the accuracy and precision of a contact lens overrefraction method in estimating corneal refractive power without using cataractous eyes; and b) we will test the hypothesis that our refined contact lens over-refraction method can be used in calculating IOL power in eyes that have developed cataracts. We will use a prospective cohort study to compare refractive complications post-cataract surgery between post-refractive surgery patients and cataractous eyes with normal corneas. Refractive surgery is a common method of vision correction, with at least 1.5 million procedures in 2000, and as many as 26.5 million within the next dozen years. Hence, it is critical that an accurate, precise and simple method to estimate corneal power and calculate IOL power is developed. The long-term objective to this research is to contribute to the knowledge of IOL power determination in post-refractive surgery patients.

描述（由申请人提供）：该提案的主要目标是培训申请人作为卫生专业人员，成为独立调查员。为了实现这一目标，描述了一个为期五年的指导培训计划，其中包括流行病学和生物统计学方面的大量教学课程，该计划将获得流行病学博士学位。 已选出六位在流行病学、生物统计学、临床研究、白内障和屈光手术以及理论光学方面具有专业知识的导师。 该提案的第二个目标是调查目前在接受过近视屈光手术并需要白内障摘除和人工晶体植入的眼睛中角膜屈光力估计和人工晶状体（IOL）屈光力计算的不准确性。 目前用于计算非手术眼 IOL 屈光力的方法在屈光手术后并不准确，并且会导致高达 83-100% 的白内障手术后眼睛出现无意远视。 历史临床数据，屈光手术后估计角膜屈光力的“金标准”很少可用，特别是几十​​年后当需要进行白内障手术时。 我们建议：a）使用横截面确定理论模型 这项研究将使我们能够评估和改进隐形眼镜过度屈光方法在不使用白内障眼睛的情况下估计角膜屈光力的准确性和精密度； b) 我们将检验这样一个假设：我们的改进隐形眼镜过度屈光方法可用于计算患有白内障的眼睛的 IOL 度数。我们将使用一项前瞻性队列研究来比较屈光手术后患者和角膜正常的白内障眼睛之间白内障手术后的屈光并发症。 屈光手术是一种常见的视力矫正方法，2000年至少有150万例手术，在接下来的十几年里将多达2650万例。 因此，开发一种准确、精确且简单的方法来估计角膜屈光力并计算人工晶状体屈光力至关重要。这项研究的长期目标是增进屈光手术后患者 IOL 度数测定的知识。