Corneal Refractive Power Post Refractive Surgery

屈光手术后的角膜屈光力

• 批准号: 7484147
• 负责人: CHARLOTTE E JOSLIN
• 金额: $ 14.19万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-06 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7484147
• 关键词: Age; Award; Biometry; Cataract; Cataract Extraction; Characteristics; Chicago; Clinical Data; Clinical Research; Clinical Trials; Cohort Studies; Complex; Contact Lenses; Cornea; Cross-Sectional Studies; Data; Depth; Doctor of Philosophy; Epidemiology; Eye; Faculty; Goals; Gold; Health Professional; Hyperopia; Illinois; Intraocular lens implant device; Knowledge; Lead; Length; Mentors; Mentorship; Methods; Myopia; Numbers; Operative Surgical Procedures; Ophthalmologic Surgical Procedures; Ophthalmology; Patients; Pilot Projects; Placement; Procedures; Public Health Schools; Reporting; Research; Research Personnel; Scientist; Standards of Weights and Measures; Testing; Theoretical model; Training; Training Programs; Training Support; Universities; Vision; Vision research; anterior chamber; data management; design; experience; improved; lens; member; prospective; vision science

DESCRIPTION (provided by applicant): The primary goal of this proposal is to train the applicant as a health professional to become an independent investigator. To achieve this goal, a five-year, mentored training program with heavy didactic coursework in epidemology and biostatistics is described that will lead to a PhD in epidemiology. Six mentors, with expertise in epidemiology, biostatistics, clinical research, cataract and refractive surgery, and theoretical opticas have been selected. The secondary goal of this proposal is to investigate the current inaccuracies of corneal power estimation and intraocular lens (IOL) power calculation in eyes that have undergone myopic refractive surgery and require cataract extraction and IOL placement. Current methods used to calculate IOL power in non-surgical eyes are inaccurate post-refractive surgery and cause unintentional hyperopia in up to 83-100% of eyes post-cataract surgery. Historical clinical data, the "gold standard" in estimating corneal power post-refractive surgery is rarely available, especially decades later when cataract surgery is necessary. We propose to: a) identify a theoretical model using a cross-sectional study that will allow us to evaluate and refine the accuracy and precision of a contact lens overrefraction method in estimating corneal refractive power without using cataractous eyes; and b) we will test the hypothesis that our refined contact lens over-refraction method can be used in calculating IOL power in eyes that have developed cataracts. We will use a prospective cohort study to compare refractive complications post-cataract surgery between post-refractive surgery patients and cataractous eyes with normal corneas. Refractive surgery is a common method of vision correction, with at least 1.5 million procedures in 2000, and as many as 26.5 million within the next dozen years. Hence, it is critical that an accurate, precise and simple method to estimate corneal power and calculate IOL power is developed. The long-term objective to this research is to contribute to the knowledge of IOL power determination in post-refractive surgery patients.

描述（由申请人提供）：该提案的主要目标是培训申请人为卫生专业人员，以成为独立调查员。为了实现这一目标，描述了一项为期五年的指导培训计划，其中描述了流行病学和生物统计学的大量教学课程，该课程将导致流行病学博士学位。 已经选择了六位指导者，具有流行病学，生物统计学，临床研究，白内障和屈光手术以及理论光学的专业知识。 该提案的次要目标是研究目前对具有近视屈光手术并需要白内障提取和IOL放置的眼睛中角膜功率估计和眼内透镜（IOL）功率计算的不准确性。 目前用于计算非手术眼睛中IOL功率的方法是不准确的后手术手术，并在高达83-100％的眼睛后手术手术中导致无意的远视。 历史临床数据，即估计角膜功率后手术后的“黄金标准”很少获得，尤其是在需要白内障手术的数十年后。 我们建议：a）使用横截面确定理论模型 研究将使我们能够评估和完善隐形眼镜过度折射方法的准确性和精度，而无需使用白内障眼睛，可以估算角膜屈光力； b）我们将检验以下假设：我们精制的隐形眼镜超差异方法可用于计算产生白内障的眼睛中的IOL功率。我们将使用一项前瞻性队列研究来比较传播后手术患者与白内障眼睛正常角膜的折射并发症。 屈光手术是一种常见的视力矫正方法，在2000年至少有150万手术，在接下来的十几年中多达2650万。 因此，至关重要的是要开发出一种准确，精确和简单的方法来估计角膜功率并计算IOL功率。这项研究的长期目标是为后施加手术患者的IOL功率确定的知识做出贡献。

项目成果

Microsporidia and Acanthamoeba: the role of emerging corneal pathogens.

微孢子虫和棘阿米巴：新兴角膜病原体的作用。

• DOI: 10.1038/eye.2011.315
• 发表时间: 2012
• 期刊: Eye (London, England)
• 作者: Tu,EY;Joslin,CE
• 通讯作者: Joslin,CE

Sequential corneal infection with two genotypically distinct Acanthamoebae associated with renewed contact lens wear.

两种基因型不同的棘阿米巴引起的连续角膜感染与重新佩戴隐形眼镜有关。

• DOI: 10.1038/eye.2009.288
• 发表时间: 2010
• 期刊: Eye (London, England)
• 作者: Tu,EY;Joslin,CE;Shoff,ME;Lee,JA;Fuerst,PE
• 通讯作者: Fuerst,PE

Shifting distribution of Chicago-area Acanthamoeba keratitis cases.

芝加哥地区棘阿米巴角膜炎病例的分布变化。

• DOI: 10.1001/archophthalmol.2009.337
• 发表时间: 2010
• 期刊: Archives of ophthalmology (Chicago, Ill. : 1960)
• 作者: Joslin,CharlotteE;Tu,ElmerY;Shoff,MeganE;Anderson,RobertJ;Davis,FaithG
• 通讯作者: Davis,FaithG

Successful treatment of chronic stromal acanthamoeba keratitis with oral voriconazole monotherapy.

• DOI: 10.1097/ico.0b013e3181cbfa2c
• 发表时间: 2010-09
• 期刊: Cornea
• 影响因子: 2.8
• 作者: Tu EY;Joslin CE;Shoff ME
• 通讯作者: Shoff ME

Acanthamoeba keratitis: the persistence of cases following a multistate outbreak.

棘阿米巴角膜炎：多州爆发后病例持续存在。

• DOI: 10.3109/09286586.2012.681336
• 发表时间: 2012
• 期刊: Ophthalmic epidemiology
• 影响因子: 1.8
• 作者: Yoder,JonathanS;Verani,Jennifer;Heidman,Nancy;Hoppe-Bauer,Joan;Alfonso,EduardoC;Miller,Darlene;Jones,DanB;Bruckner,David;Langston,Roger;Jeng,BennieH;Joslin,CharlotteE;Tu,Elmer;Colby,Kathryn;Vetter,Emily;Ritterband,David